Sulfide:quinone oxidoreductase ameliorates neurodegeneration in a murine model of Parkinson's disease

Recent advances in sulfur biology and chemistry

“…The same group demonstrate that CBS also promotes pseudohypoxia leading to a shift from oxidative phosphorylation to glycolysis and therefore to decreased mitochondrial ATP production in this disease, representing another example for the regulatory roles of sulfide in cellular bioenergetics [ 18 ]. In Parkinson's disease, increased activity of sulfide:quinone oxidoreductase, responsible for the oxidation of sulfide, diminish neurodegeneration in a murine model by Nagashima et al [ 19 ]. In contrast, in Alzheimer's disease, Rao et al show that stimulation of the H 2 S-producing enzyme 3-mercaptopyruvate sulfurtransferase (3MST) reduces oxidative stress and ameliorates disease pathology [ 20 ].…”