Sulfite Oxidase Activity of Cytochrome C: Role of Hydrogen Peroxide

Murugesan, V.; Hemann, Craig; Cardounel, Arturo J.; Zweíer, Jay L.

doi:10.1016/j.freeradbiomed.2015.10.095

Cited by 5 publications

(4 citation statements)

References 75 publications

(124 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Annotations indicate that cyt-c-p functions directly in mitochondrial respiration, whereas the upregulated cyt-c-d in 91-R is involved with apoptosis via caspase activation as well as sperm differentiation and does not regulate cellular respiration ( Arama et al 2006 , Mendes et al 2006 ). cyt-c has also been implicated in caspase activation, apoptosis, and antioxidant and peroxidase activity in mammalian systems ( Korshunov et al 1999 , Kagan et al 2004 , Velayutham et al 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Variation in Mitochondria-Derived Transcript Levels Associated With DDT Resistance in the91-RStrain ofDrosophila melanogaster(Diptera: Drosophilidae)

Steele

Coates

Seong

et al. 2018

Journal of Insect Science

View full text Add to dashboard Cite

The organochloride insecticide dichlorodiphenyltrichloroethane (DDT) and its metabolites can increase cellular levels of reactive oxygen species (ROS), cause mitochondrial dysfunction, and induce apoptosis. The highly DDT-resistant Drosophila melanogaster Meigen 1830 (Drosophila) strain, 91-R, and its susceptible control, 91-C, were used to investigate functional and structural changes among mitochondrial-derived pathways. Resequencing of mitochondrial genomes (mitogenomes) detected no structural differences between 91-R and 91-C, whereas RNA-seq suggested the differential expression of 221 mitochondrial-associated genes. Reverse transcriptase-quantitative PCR validation of 33 candidates confirmed that transcripts for six genes (Cyp12d1-p, Cyp12a4, cyt-c-d, COX5BL, COX7AL, CG17140) were significantly upregulated and two genes (Dif, Rel) were significantly downregulated in 91-R. Among the upregulated genes, four genes are duplicated within the reference genome (cyt-c-d, CG17140, COX5BL, and COX7AL). The predicted functions of the differentially expressed genes, or known functions of closely related genes, suggest that 91-R utilizes existing ROS regulation pathways of the mitochondria to combat increased ROS levels from exposure to DDT. This study represents, to our knowledge, the initial investigation of mitochondrial genome sequence variants and functional adaptations in responses to intense DDT selection and provides insights into potential adaptations of ROS management associated with DDT selection in Drosophila.

show abstract

Section: Discussionmentioning

confidence: 99%

Variation in Mitochondria-Derived Transcript Levels Associated With DDT Resistance in the91-RStrain ofDrosophila melanogaster(Diptera: Drosophilidae)

Steele

Coates

Seong

et al. 2018

Journal of Insect Science

View full text Add to dashboard Cite

show abstract

“…Velayutham et al. (2016) proposed that sulfite is oxidised by mitochondrial cytochrome c (Fe3+) to the sulfite radical (SO3· − ) which further reacts with oxygen to form peroxymonosulfate and other oxidants.…”

Section: Assessmentmentioning

confidence: 99%

Follow‐up of the re‐evaluation of sulfur dioxide (E 220), sodium sulfite (E 221), sodium bisulfite (E 222), sodium metabisulfite (E 223), potassium metabisulfite (E 224), calcium sulfite (E 226), calcium bisulfite (E 227) and potassium bisulfite (E 228)

Younes¹,

Aquilina²,

Castle³

et al. 2022

EFS2

View full text Add to dashboard Cite

Sulfur dioxide–sulfites (E 220–228) were re‐evaluated in 2016, resulting in the setting of a temporary ADI of 0.7 mg SO2 equivalents/kg bw per day. Following a European Commission call for data, the present follow‐up opinion assesses data provided by interested business operators (IBOs) and additional evidence identified in the publicly available literature. No new biological or toxicological data addressing the data gaps described in the re‐evaluation were submitted by IBOs. Taking into account data identified from the literature search, the Panel concluded that there was no substantial reduction in the uncertainties previously identified in the re‐evaluation. Therefore, the Panel considered that the available toxicity database was inadequate to derive an ADI and withdrew the current temporary group acceptable daily intake (ADI). A margin of exposure (MOE) approach was considered appropriate to assess the risk for these food additives. A lower confidence limit of the benchmark dose of 38 mg SO2 equivalents/kg bw per day, which is lower than the previous reference point of 70 mg SO2 equivalents/kg bw per day, was estimated based on prolonged visual evoked potential latency. An assessment factor of 80 was applied for the assessment of the MoE. At the estimated dietary exposures, when using a refined exposure scenario (Data set D), MOEs at the maximum of 95th percentile ranges were below 80 for all population groups except for adolescents. The dietary exposures estimated using the maximum permitted levels would result in MOEs below 80 in all population groups at the maximum of the ranges of the mean, and for most of the population groups at both minimum and maximum of the ranges at the 95th percentile. The Panel concluded that this raises a safety concern for both dietary exposure scenarios. The Panel also performed a risk assessment for toxic elements present in sulfur dioxide–sulfites (E 220–228), based on data submitted by IBOs, and concluded that the maximum limits in the EU specifications for arsenic, lead and mercury should be lowered and a maximum limit for cadmium should be introduced.

show abstract

“…As the results, the excessive accumulation of sulfites may induce cholinergic mediated bronchoconstriction in some individuals. The release of chemical and cellular mediators may be mediated by Immunoglobulin E (IgE) or non‐IgE mechanisms (Velayutham, Hemann, Cardounel, & Zweier, 2016).…”

Section: Chemical and Biochemical Propertiesmentioning

confidence: 99%

Sulfites in meat: Occurrence, activity, toxicity, regulation, and detection. A comprehensive review

D’Amore

Taranto

Berardi

et al. 2020

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

Sulfites are a class of chemical compounds, SO2 releasers, widely used as additives in food industry, due to their antimicrobial, color stabilizing, antibrowning, and antioxidant properties. As the results of these pleiotropic functions they can be added to a broad range of products including dried fruits and vegetables, seafood, juices, alcoholic and nonalcoholic beverage, and in few meat products. Sulfites ingestion has been correlated with several adverse and toxic reactions, such as hypersensitivity, allergic diseases, vitamin deficiency, and may lead to dysbiotic events of gut and oral microbiota. In many countries, these additives are closely regulated and in meat products the legislation restricts their usage. Several studies have been conducted to investigate the sulfites contents in meat and meat products, and many of them have revealed that some meat preparations represent one of the main sources of SO2 exposure, especially in adults and young people. This review discusses properties, technological functions, regulation, and health implications of sulfites in meat‐based foods, and lays a special emphasis on the chemical mechanisms involved in their interactions with organic and inorganic meat components.

show abstract

Sulfite Oxidase Activity of Cytochrome C: Role of Hydrogen Peroxide

Cited by 5 publications

References 75 publications

Variation in Mitochondria-Derived Transcript Levels Associated With DDT Resistance in the91-RStrain ofDrosophila melanogaster(Diptera: Drosophilidae)

Variation in Mitochondria-Derived Transcript Levels Associated With DDT Resistance in the91-RStrain ofDrosophila melanogaster(Diptera: Drosophilidae)

Follow‐up of the re‐evaluation of sulfur dioxide (E 220), sodium sulfite (E 221), sodium bisulfite (E 222), sodium metabisulfite (E 223), potassium metabisulfite (E 224), calcium sulfite (E 226), calcium bisulfite (E 227) and potassium bisulfite (E 228)

Sulfites in meat: Occurrence, activity, toxicity, regulation, and detection. A comprehensive review

Contact Info

Product

Resources

About