Sulfonamide-1,2,4-triazole derivatives as antifungal and antibacterial agents: Synthesis, biological evaluation, lipophilicity, and conformational studies

New Thiosemicarbazides and 1,2,4-Triazolethiones Derived from 2-(Ethylsulfanyl) Benzohydrazide as Potent Antioxidants

“…These facts have provided the basis for the discovery of new, safer and effective synthetic alternatives. A considerable amount of attention has been devoted to the synthesis of thiosemicarbazide and 1,2,4-triazole derivatives due to their wide range of pharmacological activities, such as their antitumor [9], antibacterial [10], antiproliferative activities [11], and many of them show significant in vitro antioxidant activity [12].…”

Antimicrobial and cytotoxic activities of 1,2,3-triazole-sucrose derivatives

“…It is known that Gram positive bacterial species are more susceptible to antimicrobial agents than Gram negative bacteria, and that fungi are more susceptible than bacteria in general. 42,43 Thus, the susceptibility of microorganisms to external agents depends not only on their properties, but also on the microorganism itself. …”

Synthesis of a Series of Novel Tetra-tert-butylcalix[4]arene Linked to 1,2,4-Triazole and 1,3,4-Oxadiazole Derivatives

“…Calix [4]arenes have been investigated for their biological proprieties; for example hydrophilic derivatives have shown interesting levels of activity against bacteria, cancerous cell, fungi, enveloped virus thrombosis, and fibrosis diseases. [8][9][10][11][12][13][14] 1,2,4-Triazole-5-thiones and 1,3,4-oxadiazole-5-thiones scaffolds are heterocyclic compounds containing five membered rings and their derivatives have been studied due to their diverse pharmacological proprieties, such as antibacterial and antifungal, [15][16][17][18][19][20][21][22] antimicrobial, [23][24][25] anti-inflammatory, 22,26 and antiviral activities. 27,28 Calix [4]arenes represent a third generation of supramolecular hosts after cyclodextrins and crown ethers, with unique three-dimensional structures.…”