Sulfonamide therapy of subacute bacterial endocarditis

Schein, Joseph; Baehr, George

doi:10.1016/0002-9343(48)90373-8

Cited by 9 publications

(10 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hereafter, 14 more articles were excluded based on exclusion criteria (Additional file 2), leaving 11 studies for the final analyses [9-19] (Figure 1). Of these, 9 were observational [9-17] and 2 were randomized controlled trials (RCTs) [18,19]. Tables 1 and 2 summarize the characteristics of the selected studies.…”

Section: Resultsmentioning

confidence: 99%

“…Three (33%) of these studies were of prospective design [10-12] and 6 (67%) were retrospective [9,13-17]. Two (22%) studies focused on left- sided IE [9,12], one in right-sided IE (11%) [10], and six (60%) did not specify this information [11,13-17]. One study (11%) involved only intravenous drug users (IVDUs) [10] and one (11%) involved only paediatric cases [13] (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…One study (11%) relied on modified Duke’s criteria for the diagnosis of IE [9]; two studies (22%) used a combination of suggestive clinical findings, echocardiographic findings and positive blood cultures [10,11]; four studies (44%) made this diagnosis based of the pre-existence of valvular disease and the presence of suggestive clinical findings and/or positive blood cultures [12,13,15,16]; and two studies (22%) did not provide case definitions [14,17]. Only three studies specified inclusion and exclusion criteria [9-11].…”

Section: Resultsmentioning

confidence: 99%

“…Four studies (44%) used oral antibiotic therapy for the entire duration of treatment [11,14,16,17], two (22%) used oral therapy along with adjuvant parenteral streptomycin for the first 2 weeks of treatment [12,15], and three (33%) used oral therapy only after an initial short course (<2 weeks) of IV antibiotics [9,10,13]. Oral therapies included beta-lactams (amoxicillin, penicillin V, ampicillin, cloxacillin and dicloxacillin) - with or without probenecid - in five (56%) studies [11-15]; fluoroquinolones (ciprofloxacin) in combination with rifampin in one (16%) [10]; and sulfonamide, aureomycin and linezolid in one study each [9,16,17].…”

Section: Resultsmentioning

confidence: 99%

“…Oral therapies included beta-lactams (amoxicillin, penicillin V, ampicillin, cloxacillin and dicloxacillin) - with or without probenecid - in five (56%) studies [11-15]; fluoroquinolones (ciprofloxacin) in combination with rifampin in one (16%) [10]; and sulfonamide, aureomycin and linezolid in one study each [9,16,17]. …”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

Oral antibiotic therapy for the treatment of infective endocarditis: a systematic review

et al. 2014

View full text Add to dashboard Cite

BackgroundThe role of oral antibiotic therapy in treating infective endocarditis (IE) is not well established.MethodsWe searched MEDLINE, EMBASE and Scopus for studies in which oral antibiotic therapy was used for the treatment of IE.ResultsSeven observational studies evaluating the use oral beta-lactams (five), oral ciprofloxacin in combination with rifampin (one), and linezolid (one) for the treatment of IE caused by susceptible bacteria reported cure rates between 77% and 100%. Two other observational studies using aureomycin or sulfonamide, however, had failure rates >75%. One clinical trial comparing oral amoxicillin versus intravenous ceftriaxone for streptococcal IE reported 100% cure in both arms but its reporting had serious methodological limitations. One small clinical trial (n = 85) comparing oral ciprofloxacin and rifampin versus conventional intravenous antibiotic therapy for uncomplicated right-sided S. aureus IE in intravenous drug users (IVDUs) reported cure rates of 89% and 90% in each arm, respectively (P =0.9); however, drug toxicities were more common in the latter group (62% versus 3%; P <0.01). Major limitations of this trial were lack of allocation concealment and blinding at the delivery of the study drug(s) and assessment of outcomes.ConclusionReported cure rates for IE treated with oral antibiotic regimens vary widely. The use of oral ciprofloxacin in combination with rifampin for uncomplicated right-sided S. aureus IE in IVDUs is supported by one small clinical trial of relatively good quality and could be considered when conventional IV antibiotic therapy is not possible.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Oral antibiotic therapy for the treatment of infective endocarditis: a systematic review

et al. 2014

View full text Add to dashboard Cite

show abstract

Erkrankungen des Endokard

Schölmerich¹

1960

Rhythmus- Und Leitungsstörungen Traumatische Herzschädigungen Erkrankungen Des Endokard · Myokard · Perikard · Spezielle Kardio

View full text Add to dashboard Cite

Current Evidence on Oral Antibiotics for Infective Endocarditis: A Narrative Review

et al. 2019

View full text Add to dashboard Cite

Infective endocarditis (IE) continues to be associated with high morbidity and mortality, even when treated with optimal antibiotic regimens. The selection of treatment depends on the causative pathogen, its antibiotic susceptibility profile, local and systemic complications and the presence of prosthetic materials or devices. Standard therapy typically involves 4–6 weeks of intravenous (IV) bactericidal therapy. However, there are instances in which IV antibiotic administration may be challenging due to cost, complications of IV access, adverse side-effects of the medication or concerns for misuse of the IV line. Current clinical guidance from the American Heart Association and the European Society of Cardiology cite scenarios where oral antibiotics can be considered for treatment of IE, though these situations are relatively infrequent and data to show their non-inferiority limited. Recently, a well-designed randomized clinical study reported favorable outcomes for partial oral antimicrobial therapy regimens given to patients with staphylococcal, streptococcal and enterococcal IE deemed clinically stable and without complications such as perivalvular abscess. Oral antibiotics, usually given in combination, were selected by infectious disease providers for their favorable pharmacologic properties and predicted bactericidal activity. There was a careful selection of patients who were transitioned to oral regimens. Before recommending routine use of oral antibiotics in the care of patients with IE, additional studies that better define eligible patients and that use regimens available in the countries that adopt this practice should be performed. If further studies confirm non-inferior outcomes with partial oral antibiotics for the treatment of IE, medical treatment could be delivered in a simpler, more costeffective manner, and likely with lower rates of adverse side-effects.

show abstract

Sulfonamide therapy of subacute bacterial endocarditis

Cited by 9 publications

References 6 publications

Oral antibiotic therapy for the treatment of infective endocarditis: a systematic review

Oral antibiotic therapy for the treatment of infective endocarditis: a systematic review

Erkrankungen des Endokard

Current Evidence on Oral Antibiotics for Infective Endocarditis: A Narrative Review

Contact Info

Product

Resources

About