2017
DOI: 10.1007/s11164-017-3114-1
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Sulfonamides and carbamates of 3-fluoro-4-morpholinoaniline (linezolid intermediate): synthesis, antimicrobial activity and molecular docking study

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Cited by 18 publications
(4 citation statements)
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“…In light of this, our in silico research has centered around DNA gyrase topoisomerase II (PDB: 1KZN)—an enzyme sourced from the E. coli bacterium that is made up of two subunits, GyrA and GyrB. Recent studies have revealed that this enzyme plays a key role in controlling the topological state of bacterial genomes and can be found in all species [ 42 , 43 ]. The compounds detected in PVEO exhibited affinities ranging from −4.6 to −6.2 kcal/mol and did not demonstrate sufficient inhibitory potential.…”
Section: Resultsmentioning
confidence: 99%
“…In light of this, our in silico research has centered around DNA gyrase topoisomerase II (PDB: 1KZN)—an enzyme sourced from the E. coli bacterium that is made up of two subunits, GyrA and GyrB. Recent studies have revealed that this enzyme plays a key role in controlling the topological state of bacterial genomes and can be found in all species [ 42 , 43 ]. The compounds detected in PVEO exhibited affinities ranging from −4.6 to −6.2 kcal/mol and did not demonstrate sufficient inhibitory potential.…”
Section: Resultsmentioning
confidence: 99%
“…Many mechanisms were reported to be a significant target for antibacterial agents. One of these targets is the DNA gyrase enzyme found in all bacterial and controls, the topological state of DNA [ 41 , 42 ]. Similarly, the DHFR enzyme catalyzes NADPH reduction to NADP+ by converting dihydrofolate to tetrahydrofolate, which is an essential cofactor for the biosynthesis of purine nucleotides and thymidine, as well as many amino acids, and inhibition of this enzyme disrupts DNA synthesis and cell death [ 43 , 44 ].…”
Section: Introductionmentioning
confidence: 99%
“…A common structural feature of the most active compounds 6e , 6k , and 6r is the presence of a nitro substituent. Hence, it can be assumed that the introduction of a nitro group is highly beneficial for antifungal activity [ 18 , 19 , 20 ]. It is possible to note a correlation between antifungal activity with an electron withdrawing nitro group because the substition of this group affected pKa, hydrophobic interactions and also lipophilicity, which are citical to enhanced biological activity.…”
Section: Resultsmentioning
confidence: 99%