Sulfonated PVA microspheres for drug delivery and simulated body fluid interaction

Verón, María Gisela; Soria, Luciano Álvarez; Pérez, Pablo Daniel; Prado, Miguel Oscar

doi:10.1080/10601325.2022.2154163

Cited by 2 publications

(1 citation statement)

References 39 publications

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“…Various kinetic models, including zero-order, first-order, Higuchi, and Korsmeyer-Peppas, were employed to validate and elucidate the underlying mechanism of drug release. To predict the release behavior of the drug, it is imperative to analyze diverse outcomes derived from fitting the data to a range of validated mathematical models [45,46]. These kinetic models elucidate whether the drug release is contingent on dissolution or diffusion.…”

Section: Drug Release Kinetic Modelsmentioning

confidence: 99%

Porous Microgels for Delivery of Curcumin: Microfluidics-Based Fabrication and Cytotoxicity Evaluation

Orbay,

Sanyal,

Sanyal

2023

Micromachines

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Polymeric microgels, fabricated via microfluidic techniques, have garnered significant interest as versatile drug delivery carriers. Despite the advances, the loading and release of hydrophobic drugs such as curcumin from polymeric microgels is not trivial. Herein, we report that effective drug loading can be achieved by the design of porous particles and the use of supramolecular cyclodextrin-based curcumin complexes. The fabrication of porous microgels through the judicious choice of chemical precursors under flow conditions was established. The evaluation of the curcumin loading dependence on the porosity of the microgels was performed. Microgels with higher porosity exhibited better curcumin loading compared to those with lower porosity. Curcumin-loaded microgels released the drug, which, upon internalization by U87 MG human glioma cancer cells, induced cytotoxicity. The findings reported here provide valuable insights for the development of tailored drug delivery systems using a microfluidics-based platform and outline a strategy for the effective delivery of hydrophobic therapeutic agents such as curcumin through supramolecular complexation.

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Section: Drug Release Kinetic Modelsmentioning

confidence: 99%