Sulfones in Solid‐Phase Heterocycle Synthesis

Solid-Supported Hydrazone of 4-(4′-Formyl-3′-methoxyphenoxy)butyric Acid As a New Traceless Linker for Solid-Phase Synthesis

“…Acid-sensitive silyl and germanium linkers are among the earliest developed and most useful traceless linkers. − Highly resistant sulfone linkers represent another group of traceless linkers. − The drawbacks of these linkers are poor availability and high cost of cleavage reagents (cuprate, organomalybdenum or organopalladium agents). Moreover, the final compounds may form metal ion complexes.…”