Sulfonylurea and non-sulfonylurea hypoglycemic agents: pharmachological properties and tissue selectivity

Nagashima, Kazuaki; Takahashi, Akira; Ikeda, Hiroki; Hamasaki, Akihiro; Kuwamura, Naomitsu; Yamada, Yoshio; Seino, Yutaka

doi:10.1016/j.diabres.2003.12.011

Cited by 31 publications

(18 citation statements)

References 17 publications

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“…Further, proper mobilization of fat from the fat body is perturbed in the absence of oenocytes-an interaction reminiscent of the crosstalk between hepatocytes and adipocytes in humans 9,13 . Additional 14 . Drosophila larvae fed with sulphonylurea show increased sugar levels, suggesting that AKH-expressing cells in the fly use a conserved mechanism for coupling circulating sugars to glucagon and AKH release 4 .…”

Section: Metabolic Homeostasismentioning

confidence: 99%

Drosophila and the genetics of the internal milieu

Léopold

Perrimon

2007

Nature

170

138

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Section: Metabolic Homeostasismentioning

confidence: 99%

Drosophila and the genetics of the internal milieu

Léopold

Perrimon

2007

Nature

170

138

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“…Their most common adverse effect is hypoglycemia. Also, these agents stimulate appetite and often cause weight gain [102][103].…”

Section: Mode Of Action and Adverse Effects Of Exogenous Insulin And mentioning

confidence: 99%

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Gushiken¹,

Beserra²,

Rozza³

et al. 2016

Rev Diabet Stud

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■ AbstractDiabetes mellitus is a chronic disease and a leading cause of death in western countries. Despite advancements in the clinical management of the disease, it is not possible to control the late complications of diabetes. The main characteristic feature of diabetes is hyperglycemia, which reflects the deterioration in the use of glucose due to a faulty or poor response to insulin secretion. Alloxan and streptozotocin (STZ) are the chemical tools that are most commonly used to study the disease in rodents. Many plant species have been used in ethnopharmacology or to treat experimentally symptoms of this disease. When evaluated pharmacologically, most of the plants employed as antidiabetic substances have been shown to exhibit hypoglycemic and antihyperglycemic activities, and to contain chemical constituents that may be used as new antidiabetic agents. There are many substances extracted from plants that offer antidiabetic potential, whereas others may result in hypoglycemia as a side effect due to their toxicity, particularly their hepatotoxicity. In this article we present an updated overview of the studies on extracts from medicinal plants, relating the mechanisms of action by which these substances act and the natural principles of antidiabetic activity.

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“…11. Схема взаимодействия различных препаратов сульфонилмочевины с рецепторами К + АТФ -кана-лов миокардиоцитов (стрелки -блокирующее действие; Т-образные линии -отсутствие бло-кирующего действия) [28] …”

Section: сердечно-сосудистые последствия сахароснижающей терапииunclassified

“…менении глимепирида, оставляющим открытыми K + АТФ -каналы мембран миокардиальных митохондрий [28] (рис. 11).…”

Section: сердечно-сосудистые последствия сахароснижающей терапииunclassified

Reduction of Cardiovascular Complications of Modern Hypoglycemic Therapy of Diabetes Mellitus Type 2: "Florentine Heresy"

Александров¹

2010

Racionalʹnaâ farmakoterapiâ v kardiologii

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Эндокринологический научный центр. 117036, Москва, ул. Дмитрия Ульянова, 11Снижение сердечно-сосудистых осложнений современной сахароснижающей терапии сахарного диабета 2 типа: «флорентийская ересь» А.А. Александров* Эндокринологический научный центр. 117036, Москва, ул. Дмитрия Ульянова, 11Классические гипогликемические препараты включают бигуаниды, препараты сульфонилмочевины, меглитиниды, глитазоны и ингибиторы альфа-глюкозидазы. Современный алгоритм гипогликемической терапии на первой ступени предполагает изменение образа жизни и монотерапию метформином, на второй ступени -комбинированную терапию. Однако влияние комбинаций сахароснижающих препаратов на долгосрочный сердечно-сосудистый прогноз у пациентов с сахарным диабетом 2 типа изучено недостаточно. Ком-бинированная терапия глибенкламидом и метформином может иметь неблагоприятные сердечно-сосудистые эффекты, в связи с чем необходимо избегать длительного ее при-менения у пациентов с коронарной болезнью сердца и разработать адекватные фармакологические подходы к коррекции гипергликемии. Ключевые слова: сахарный диабет, комбинированная гипогликемическая терапия, метформин, препараты сульфонилмочевины. The classic hypoglycemic agents include biguanides, sulfonylurea drugs, meglitinides, glitazones and alpha-glucosidase inhibitors. Modern algorithm of hypoglycemic therapy in the first step considers lifestyle modification and metformin monotherapy, the second step -the combined therapy. However, the effect of combined hypoglycemic therapy on long-term cardiovascular prognosis in patients with type 2 diabetes mellitus is studied insufficiently. Combined therapy with glibenclamide and metformin can result in adverse cardiovascular effects, so that long term therapy should be avoided in patients with coronary heart disease. Adequate pharmacological approaches to hyperglycemia correction should be elaborated.

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Sulfonylurea and non-sulfonylurea hypoglycemic agents: pharmachological properties and tissue selectivity

Cited by 31 publications

References 17 publications

Drosophila and the genetics of the internal milieu

Drosophila and the genetics of the internal milieu

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Reduction of Cardiovascular Complications of Modern Hypoglycemic Therapy of Diabetes Mellitus Type 2: "Florentine Heresy"

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