Sulforaphane as a potential remedy against cancer: Comprehensive mechanistic review

Haq, Iahtisham‐Ul; Khan, Sipper; Awan, Kanza Aziz; Iqbal, Muhammad Jawad

doi:10.1111/jfbc.13886

Cited by 26 publications

(17 citation statements)

References 300 publications

(326 reference statements)

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“…GLSs are relatively inactive and necessitate hydrolysis by plant endogenous myrosinase (MYR) to deliver a variety of bioactive compounds, such as isothiocyanates (ITCs) and indoles. Neutral pH conditions are favorable for the formation of ITCs [ 137 , 138 ]. GLSs and the enzyme MYR are stored in different compartments of plant cells, requiring plant tissue to be damaged for cellular breakdown to occur and MYR to be released and act on GLSs.…”

Section: Nutraceuticalsmentioning

confidence: 99%

“…Concerning the assimilation by the body of the GLS hydrolysis products, absorbed ITCs are conjugated to glutathione, with the involvement of glutathione-S-transferase (GST) enzymes, and metabolized via the mercapturic acid pathway [ 138 ]. The polymorphisms of genes coding for GST may have an important effect on ITC metabolism, leading to interindividual variations in the benefits from exposure to these compounds.…”

Section: Nutraceuticalsmentioning

confidence: 99%

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The Anticancer Potential of Plant-Derived Nutraceuticals via the Modulation of Gene Expression

Vranceanu

Galimberti

Banc

et al. 2022

Plants

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Current studies show that approximately one-third of all cancer-related deaths are linked to diet and several cancer forms are preventable with balanced nutrition, due to dietary compounds being able to reverse epigenetic abnormalities. An appropriate diet in cancer patients can lead to changes in gene expression and enhance the efficacy of therapy. It has been demonstrated that nutraceuticals can act as powerful antioxidants at the cellular level as well as anticarcinogenic agents. This review is focused on the best studies on worldwide-available plant-derived nutraceuticals: curcumin, resveratrol, sulforaphane, indole-3-carbinol, quercetin, astaxanthin, epigallocatechin-3-gallate, and lycopene. These compounds have an enhanced effect on epigenetic changes such as histone modification via HDAC (histone deacetylase), HAT (histone acetyltransferase) inhibition, DNMT (DNA methyltransferase) inhibition, and non-coding RNA expression. All of these nutraceuticals are reported to positively modulate the epigenome, reducing cancer incidence. Furthermore, the current review addresses the issue of the low bioavailability of nutraceuticals and how to overcome the drawbacks related to their oral administration. Understanding the mechanisms by which nutraceuticals influence gene expression will allow their incorporation into an “epigenetic diet” that could be further capitalized on in the therapy of cancer.

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Section: Nutraceuticalsmentioning

confidence: 99%

Section: Nutraceuticalsmentioning

confidence: 99%

The Anticancer Potential of Plant-Derived Nutraceuticals via the Modulation of Gene Expression

Vranceanu

Galimberti

Banc

et al. 2022

Plants

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“…Sulforaphane is an isothiocyanate derived from cruciferous plants that has recently gained considerable attention thanks to its potential anti-oxidant ( Ruhee and Suzuki, 2020 ), antitumor ( Iahtisham Ul et al, 2021 ), anti-inflammatory and neuroprotective effects ( Calabrese and Kozumbo, 2021 ; Mangla et al, 2021 ), through the activation of the Nrf2 pathway ( Petrillo et al, 2019 ; Uddin et al, 2020 ). It is currently sold as a nutritional supplement.…”

Section: Natural Compoundsmentioning

confidence: 99%

Drug Repositioning in Friedreich Ataxia

et al. 2022

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Friedreich ataxia is a rare neurodegenerative disorder caused by insufficient levels of the essential mitochondrial protein frataxin. It is a severely debilitating disease that significantly impacts the quality of life of affected patients and reduces their life expectancy, however, an adequate cure is not yet available for patients. Frataxin function, although not thoroughly elucidated, is associated with assembly of iron-sulfur cluster and iron metabolism, therefore insufficient frataxin levels lead to reduced activity of many mitochondrial enzymes involved in the electron transport chain, impaired mitochondrial metabolism, reduced ATP production and inefficient anti-oxidant response. As a consequence, neurons progressively die and patients progressively lose their ability to coordinate movement and perform daily activities. Therapeutic strategies aim at restoring sufficient frataxin levels or at correcting some of the downstream consequences of frataxin deficiency. However, the classical pathways of drug discovery are challenging, require a significant amount of resources and time to reach the final approval, and present a high failure rate. Drug repositioning represents a viable alternative to boost the identification of a therapy, particularly for rare diseases where resources are often limited. In this review we will describe recent efforts aimed at the identification of a therapy for Friedreich ataxia through drug repositioning, and discuss the limitation of such strategies.

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“…The SFN is generated upon glucoraphanin hydrolysis. The SNF application in cancer therapy has witnessed a growing increase [ 264 ]. A recent experiment demonstrates that SFN reduces expression level of H19, as a lncRNA to suppress growth and invasion of pancreatic cancer cells [ 265 ].…”

Section: Dietary Agents and Cancer Stem Cellsmentioning

confidence: 99%

Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies

Paskeh

Asadi²,

Zabolian

et al. 2021

IJMS

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As a multifactorial disease, treatment of cancer depends on understanding unique mechanisms involved in its progression. The cancer stem cells (CSCs) are responsible for tumor stemness and by enhancing colony formation, proliferation as well as metastasis, and these cells can also mediate resistance to therapy. Furthermore, the presence of CSCs leads to cancer recurrence and therefore their complete eradication can have immense therapeutic benefits. The present review focuses on targeting CSCs by natural products in cancer therapy. The growth and colony formation capacities of CSCs have been reported can be attenuated by the dietary agents. These compounds can induce apoptosis in CSCs and reduce tumor migration and invasion via EMT inhibition. A variety of molecular pathways including STAT3, Wnt/β-catenin, Sonic Hedgehog, Gli1 and NF-κB undergo down-regulation by dietary agents in suppressing CSC features. Upon exposure to natural agents, a significant decrease occurs in levels of CSC markers including CD44, CD133, ALDH1, Oct4 and Nanog to impair cancer stemness. Furthermore, CSC suppression by dietary agents can enhance sensitivity of tumors to chemotherapy and radiotherapy. In addition to in vitro studies, as well as experiments on the different preclinical models have shown capacity of natural products in suppressing cancer stemness. Furthermore, use of nanostructures for improving therapeutic impact of dietary agents is recommended to rapidly translate preclinical findings for clinical use.

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Sulforaphane as a potential remedy against cancer: Comprehensive mechanistic review

Cited by 26 publications

References 300 publications

The Anticancer Potential of Plant-Derived Nutraceuticals via the Modulation of Gene Expression

The Anticancer Potential of Plant-Derived Nutraceuticals via the Modulation of Gene Expression

Drug Repositioning in Friedreich Ataxia

Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies

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