Sulforaphane enhances long-term potentiation and ameliorate scopolamine-induced memory impairment

Park, Ho-Sub; Hwang, Eun-Sang; Choi, Ga‐Young; Kim, Hyun-Bum; Park, Kyun-Seob; Sul, Jai‐Yoon; Hwang, Young‐Hyun; Choi, Geun Wook; Kim, Byung Il; Park, Hyun-Woo; Maeng, Sungho; Park, Ji-Ho

doi:10.1016/j.physbeh.2021.113467

Cited by 16 publications

(18 citation statements)

References 83 publications

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“…In this study, SCP contributed to memory improvement by upregulating the expression of p-CaMKII, p-CREB, and BDNF both in mice and rats with scopolamine-induced memory impairment. It was consistent with the findings of Park et al, who reported that sulforaphane enhances memory abilities by increasing the upregulation of BDNF and CREB in LTP using SD rats in scopolamine-induced memory impairment . In the LTP, a large increase in Ca 2+ , activated by glutamate receptors in the postsynaptic membrane, led to constitutive activation of calmodulin-dependent protein kinases II (CaMKII).…”

Section: Discussionmentioning

confidence: 99%

“…It was consistent with the findings of Park et al, who reported that sulforaphane enhances memory abilities by increasing the upregulation of BDNF and CREB in LTP using SD rats in scopolamine-induced memory impair-ment. 44 In the LTP, a large increase in Ca 2+ , activated by glutamate receptors in the postsynaptic membrane, led to constitutive activation of calmodulin-dependent protein kinases II (CaMKII). Constitutively, the active CaMKII then promoted synaptic strength by enhancing depolarization in postsynaptic cells.…”

Section: ■ Discussionmentioning

confidence: 99%

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Sea Cucumber Peptides Attenuated the Scopolamine-Induced Memory Impairment in Mice and Rats and the Underlying Mechanism

et al. 2021

J. Agric. Food Chem.

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Social stress and unhealthy diets lead to memory impairment, triggering health problems. This study aimed to determine the mitigating effect and regulation mechanism of sea cucumber peptides (SCP) against memory impairment. Here, scopolamine-induced memory impairment in mouse and rat models was used based on behavioral tests, a histological staining technique, Fourier transform infrared microscopy, and gas-chromatographic analysis as well as a Western blotting method. SCP improved the behavioral performance and regulated the disorder of the cholinergic system in mouse models in a dose-dependent manner. Therefore, the underlying mechanism was explored in high-dose SCP using mouse and rat models. SCP repaired damaged neuronal cells, enhanced the Nissl body number, increased the unsaturated lipid level, and activated the long-term potentiation (LTP) pathway (p-CaMKII, p-CREB, and BDNF), both in the mouse and rat hippocampus. The results indicated that SCP upregulated the LTP pathway and unsaturated lipid level to combat scopolamine-induced memory impairment, suggesting that SCP was a potential candidate for neurological recovery.

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Section: Discussionmentioning

confidence: 99%

Section: ■ Discussionmentioning

confidence: 99%

Sea Cucumber Peptides Attenuated the Scopolamine-Induced Memory Impairment in Mice and Rats and the Underlying Mechanism

et al. 2021

J. Agric. Food Chem.

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“…Sulforaphane (Table 3 ) (from sources such as Brassica oleracea ) [ 118 ] mediated degradation of misfolded huntingtin protein in mice and human cell lines through the UPS pathway [ 119 ]. Sulforaphane was also found to ameliorate scopolamine-induced memory impairment in a rat model [ 120 ]. Mouse cell lines treated with sulforaphane protected cells from Aβ1–42-mediated cell death by upregulation of the 26S proteasome [ 121 ].…”

Section: Resultsmentioning

confidence: 99%

Therapeutic roles of plants for 15 hypothesised causal bases of Alzheimer’s disease

Tyler

2022

Nat. Prod. Bioprospect.

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Alzheimer’s disease (AD) is progressive and ultimately fatal, with current drugs failing to reverse and cure it. This study aimed to find plant species which may provide therapeutic bioactivities targeted to causal agents proposed to be driving AD. A novel toolkit methodology was employed, whereby clinical symptoms were translated into categories recognized in ethnomedicine. These categories were applied to find plant species with therapeutic effects, mined from ethnomedical surveys. Survey locations were mapped to assess how this data is at risk. Bioactivities were found of therapeutic relevance to 15 hypothesised causal bases for AD. 107 species with an ethnological report of memory improvement demonstrated therapeutic activity for all these 15 causal bases. The majority of the surveys were found to reside within biodiversity hotspots (centres of high biodiversity under threat), with loss of traditional knowledge the most common threat. Our findings suggest that the documented plants provide a large resource of AD therapeutic potential. In demonstrating bioactivities targeted to these causal bases, such plants may have the capacity to reduce or reverse AD, with promise as drug leads to target multiple AD hallmarks. However, there is a need to preserve ethnomedical knowledge, and the habitats on which this knowledge depends. Graphical Abstract

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“…After 30 min, scopolamine was given (except for the control group). The present research was designed according to recent investigations [ [22] , [24] ]. All treatments were administered once per day (at 10:00 a.m.).…”

Section: Methodsmentioning

confidence: 99%

Minocycline alleviated scopolamine-induced amnesia by regulating antioxidant and cholinergic function

Ghalibaf¹,

Rajabian²,

Parviz³

et al. 2023

Heliyon

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Sulforaphane enhances long-term potentiation and ameliorate scopolamine-induced memory impairment

Cited by 16 publications

References 83 publications

Sea Cucumber Peptides Attenuated the Scopolamine-Induced Memory Impairment in Mice and Rats and the Underlying Mechanism

Sea Cucumber Peptides Attenuated the Scopolamine-Induced Memory Impairment in Mice and Rats and the Underlying Mechanism

Therapeutic roles of plants for 15 hypothesised causal bases of Alzheimer’s disease

Minocycline alleviated scopolamine-induced amnesia by regulating antioxidant and cholinergic function

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