Sulforaphane, L-Menthol, and Dexpanthenol as a Novel Active Cosmetic Ingredient Composition for Relieving Hair Loss Symptoms

Park, Youngkum; Choi, Kanghyun; Kim, Hyoseon; Lee, Jihye; Park, Gyeryeol; Kim, Junehyun

doi:10.3390/cosmetics8030063

Cited by 8 publications

(3 citation statements)

References 30 publications

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“…In light of such investigations, we conducted this study to examine if the chosen extracts can be used as hair loss prevention agents based on their cosmetological properties [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44]. To achieve our goals, we evaluated the growth-proliferation abilities of these extracts using changes in the viability of human follicle dermal papilla cells.…”

Section: Discussionmentioning

confidence: 99%

A Platform for Determining Medicinal Plants with Targeted 17β-Hydroxysteroid Dehydrogenase Modulation for Possible Hair Loss Prevention

Park,

Kaushik,

Lee

et al. 2024

Cosmetics

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Although hair loss plays a vital physiological function in present society, their impact on shaping self-esteem is undeniable. Even though there are numerous synthetic drugs available, these days, there are issues with safety, efficiency, and unclear time settings for required outcomes with the current synthetic drug remedies available; therefore, there is growing attention to discovering alternative methods to fight hair loss, primarily through plant-derived formulations. While earlier reports mostly focused on screening compounds or plant extracts affecting 5α-reductase, our research takes a unique direction. We employed a biochemical and molecular biological approach by delving into the complicated biosynthetic pathways involving 17β-hydroxysteroid dehydrogenase (17β-HSD) and 3β-hydroxysteroid dehydrogenase (3β-HSD) in producing testosterone derived from cholesterol. This process conceded requiring experimental results, posing insights into the control of the testosterone/dihydrotestosterone (DHT) production pathway. Our study confirms a discovery platform for finding potential candidates as hair loss inhibitors, highlighting exploring various biochemical mechanisms involving 17β-HSD and 3β-HSD in combination with medicinal plant extracts.

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Section: Discussionmentioning

confidence: 99%

A Platform for Determining Medicinal Plants with Targeted 17β-Hydroxysteroid Dehydrogenase Modulation for Possible Hair Loss Prevention

Park,

Kaushik,

Lee

et al. 2024

Cosmetics

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“…Studies have indicated that finasteride proficiently obstructs the enzyme responsible for converting testosterone into dihydrotestosterone, a factor known for advancing male pattern baldness. 22,23…”

Section: Exploring Minoxidil-a Game-changer In Hair Fall Treatmentmentioning

confidence: 99%

Breaking bald: Unraveling the mysteries of hair loss and modern treatments

Rathi,

Pingat,

Bhole

et al. 2024

IJCED

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Alopecia, commonly known as hair loss, presents a multifaceted challenge affecting millions worldwide. Recent advances in hair loss treatment and prevention offer hope to individuals grappling with this condition. This comprehensive overview delves into the causes of hair loss, encompassing genetics, hormonal imbalances, nutritional deficiencies, stress, and underlying medical conditions. The COVID-19 pandemic has also revealed unique patterns of hair loss i.e., telogen effluvium, prompting ongoing research and therapeutic exploration.Current treatment options, including medications like minoxidil and finasteride, surgical interventions such as hair transplants, and non-surgical techniques like laser therapy and platelet-rich plasma therapy, are examined in detail. While effective, these treatments come with limitations and potential side effects, necessitating careful consideration.Looking ahead, researchers are exploring innovative approaches to combat hair loss, from targeted medications to gene therapies and stem cell-based interventions. Advanced delivery methods using nanotechnology and biomaterials hold promise for more effective and safer solutions in the future.Recognizing the psychological impact of hair loss, this review emphasizes the importance of addressing the emotional aspects of this condition to enhance overall patient well-being. The future holds the potential for more holistic and successful treatments in the ongoing battle against hair loss, offering optimism to those seeking solutions.

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“…This enzyme degrades DHT (Figure 17). By increasing the expression of 3α-HSD or enabling its activity by restoring the redox balance, it is conceivable that levels of DHT would decrease [151]. Unfortunately, in scalps afflicted with AGA, the redox balance is impaired, and the activity of 3α-HSD is prevented due to its dependence on NADPH [120] (Figure 18).…”

Section: Strike 1: Imbalance Of Androgensmentioning

confidence: 99%

An Updated Etiology of Hair Loss and the New Cosmeceutical Paradigm in Therapy: Clearing ‘the Big Eight Strikes’

Sadgrove

Batra²,

Barreto³

et al. 2023

Cosmetics

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In this current review, research spanning the last decade (such as transcriptomic studies, phenotypic observations, and confirmed comorbidities) has been synthesized into an updated etiology of hair loss and applied to the new cosmeceutical paradigm of hair rejuvenation. The major etiological components in scalps with hair loss are denoted as the ‘big eight strikes’, which include the following: androgens, prostaglandins, overactive aerobic metabolism of glucose, bacterial or fungal over-colonization, inflammation, fibrosis, metabolism or circulation problems, and malnutrition. The relevance of the ‘big eight’ to nine categories of hair loss is explained. In cases of androgenetic alopecia or female pattern hair loss, both elevated DHT and increased frequency of androgen receptors lead to problems with the metabolism of glucose (sugar), redox imbalance, disruption to the electron transport chain, and PPAR-γ overactivity (the latter is unique to androgenetic alopecia, where the reverse occurs in other types of hair loss). These etiological factors and others from ‘the big eight’ are the focal point of our hypothetical narrative of the attenuative mechanisms of commercial cosmeceutical hair serums. We conclude that cosmeceuticals with the potential to improve all eight strikes (according to published in vitro or clinical data) utilize bioactive peptides and plant compounds that are either flavonoids (isoflavones, procyanidins, flavanols, and flavonols) or sterols/triterpenes. It is noteworthy that many therapeutic interventions are generic to the multiple types of hair loss. Lastly, suggestions are made on how scalp and hair health can be improved by following the cosmeceutical approach.

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Sulforaphane, L-Menthol, and Dexpanthenol as a Novel Active Cosmetic Ingredient Composition for Relieving Hair Loss Symptoms

Cited by 8 publications

References 30 publications

A Platform for Determining Medicinal Plants with Targeted 17β-Hydroxysteroid Dehydrogenase Modulation for Possible Hair Loss Prevention

A Platform for Determining Medicinal Plants with Targeted 17β-Hydroxysteroid Dehydrogenase Modulation for Possible Hair Loss Prevention

Breaking bald: Unraveling the mysteries of hair loss and modern treatments

An Updated Etiology of Hair Loss and the New Cosmeceutical Paradigm in Therapy: Clearing ‘the Big Eight Strikes’

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