Sulforaphane produces antidepressant- and anxiolytic-like effects in adult mice

Wu, Shu-Hui; Gao, Qiang; Zhao, Pei; Gao, Yuan; Xi, Yan-jie; Wang, Xiaoting; Liang, Ying; Shi, Haishui; Ma, Yun‐Bao

doi:10.1016/j.bbr.2015.12.030

Cited by 81 publications

(66 citation statements)

References 47 publications

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“…The forced swimming test was performed as previously described 39 , 40 . Mice were placed into a 20-cm diameter ×35-cm high plastic cylinder filled to a depth of 20 cm with 23–25 °C water for 6 minutes.…”

Section: Methodsmentioning

confidence: 99%

Molecular hydrogen increases resilience to stress in mice

Gao

Song

Wang

et al. 2017

Sci Rep

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The inability to successfully adapt to stress produces pathological changes that can lead to depression. Molecular hydrogen has anti-oxidative and anti-inflammatory activities and neuroprotective effects. However, the potential role of molecular hydrogen in stress-related disorders is still poorly understood. The present study aims to investigate the effects of hydrogen gas on resilience to stress in mice. The results showed that repeated inhalation of hydrogen-oxygen mixed gas [67%:33% (V/V)] significantly decreased both the acute and chronic stress-induced depressive- and anxiety-like behaviors of mice, assessed by tail suspension test (TST), forced swimming test (FST), novelty suppressed feeding (NSF) test, and open field test (OFT). ELISA analyses showed that inhalation of hydrogen-oxygen mixed gas blocked CMS-induced increase in the serum levels of corticosterone, adrenocorticotropic hormone, interleukin-6, and tumor necrosis factor-α in mice exposed to chronic mild stress. Finally, inhalation of hydrogen gas in adolescence significantly increased the resilience to acute stress in early adulthood, which illustrates the long-lasting effects of hydrogen on stress resilience in mice. This was likely mediated by inhibiting the hypothalamic-pituitary-adrenal axis and inflammatory responses to stress. These results warrant further exploration for developing molecular hydrogen as a novel strategy to prevent the occurrence of stress-related disorders.

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Section: Methodsmentioning

confidence: 99%

Molecular hydrogen increases resilience to stress in mice

Gao

Song

Wang

et al. 2017

Sci Rep

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“…Some natural compound exacted from herbs that used in traditional Chinese medicine was reported to have significant antidepressant activities, comparable efficiency to existing antidepressants with less side effects. [10][11][12][13][14] Our previous studies reported that several extracts from natural herb, such as sulforaphane, cipadesin A and Suhexiang have antidepressant-and anxiolytic-like effects with no significant side effects in mice. [15][16][17] Sumu, part of the plant Caesalpinia sappan L. and a classic medicine used in traditional Chinese medicine, has been widely used in China for its circulatory promoting and antiinflammation effects.…”

Section: Introductionmentioning

confidence: 99%

Brazilin Treatment Produces Antidepressant- and Anxiolytic-Like Effects in Mice

Wang

Xiu

et al. 2019

Biological & Pharmaceutical Bulletin

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Increasing evidence shows depression relevant to oxidative stress and inflammation. Anti-inflammatory strategies or antioxidants have led to the development of new antidepressants. Brazilin is a natural product from the Chinese traditional medicine Caesalpinia sappan L., exerting anti-inflammatory, antioxidant, anti-platelet concentration, and anti-cancer effects. While the antidepressant effect of brazilin is largely unknown. In present study, we investigated the effects of brazilin on H 2 O 2-induced oxidative injury in PC12 cells and on depression-and anxiety-like behaviors of chronically mild stressed (CMS)-induced depression mice. It was found that brazilin pre-treatment (both 10 and 20 µM) significantly increased cell viability and decreased cell apoptosis in H 2 O 2-treated PC12 cells. Furthermore, repetitive administration of brazilin to CMS-induced depression mice by intraperitoneal injection (10 mg/kg) made the mice significantly lose their latency of feeding in novelty-suppressed feeding test (NSF), have more the sucrose preference in sucrose preference test (SPT), and more time spent in the central zone without affecting their crossing activity in open field test (OFT). These results suggested that brazilin can play a role in antidepressant and anxiolytic-like behaviors for CMS-induced depression mice probably through inhibiting the oxidative stress. Therefore, brazilin is worth to be further explored for treating depressive and anxiety disorders.

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“…Forced Swimming Test Forced swim test (FST) was modified from our previous reports. 21,31) A 20 cm diam-eter×35 cm high plastic cylinder was filled to a depth of 20 cm water (23-25°C). Mice were introduced into the water for a 6-min test session.…”

Section: Open Field Testmentioning

confidence: 99%

“…[16][17][18] Chen and colleagues reported that the Yueju pill exerts rapid antidepressant-like effects both in rodents and in human. [19][20][21] Many kinds of constituents extracted from natural products, such as sulforaphane, and cipadesin A, could produce significant neuroprotective and antidepressant-like effects. 22,23) SuHeXiangWan (SHXW), a famous Chinese traditional medicine, is widely used to treat seizures, infantile convulsions, sudden loss of consciousness, and stroke.…”

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confidence: 99%

SuHeXiang Essential Oil Inhalation Produces Antidepressant- and Anxiolytic-Like Effects in Adult Mice

Liang

et al. 2018

Biological & Pharmaceutical Bulletin

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SuHeXiang (SHX) has been used to treat a wide range of diseases, including those related to the central nervous system. However, the effects of SHX on mood disorders are still elusive. This study aimed to investigate the effects of SHX essential oil on stress-induced depression of mice. In an acute stress-induced depression model, mice inhaled vehicle (1% Tween 80) for 10 min or 10% SHX for 10 or 30 min once daily for 12 continuous days. In the chronic mild stress (CMS)-induced depression model, mice were exposed to a 28-d CMS treatment. Tail suspension test (TST), forced swimming test (FST), sucrose preference test (SPT), open field test (OFT), and novelty suppressed feeding (NSF) test were conducted. In addition, serum levels of angiogenin (ANG), thrombopoietin (TPO), interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α) were evaluated by enzyme-linked immunosorbent assay (ELISA) assays. The results showed that in mice exposed to acute stress, repeated SHX inhalation exerted significant antidepressant and anxiolytic activities, and also reduced the serum levels of ANG, TPO, IL-6, and TNF-α. It also significantly reversed the depressive and anxiety-like behaviors, and reduced the serum levels of ANG and TPO in mice exposed to CMS. This is the first report to show that SHX inhalation could produce significant antidepressant and anxiolytic-like effects. These effects might be mediated by SHX ability to modulate the inflammatory response, and reduce dysfunction of vascular genesis and thrombosis. These results support further exploration for developing SHX inhalation as a novel therapeutic strategy for depression and stress-related disorders.

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Sulforaphane produces antidepressant- and anxiolytic-like effects in adult mice

Cited by 81 publications

References 47 publications

Molecular hydrogen increases resilience to stress in mice

Molecular hydrogen increases resilience to stress in mice

Brazilin Treatment Produces Antidepressant- and Anxiolytic-Like Effects in Mice

SuHeXiang Essential Oil Inhalation Produces Antidepressant- and Anxiolytic-Like Effects in Adult Mice

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