Sulfur Amino Acid Nutrition of the Growing Chick: Effect of Age on the Capacity of Cystine to Spare Dietary Methionine

Graber, G; Scott, H. M.; Baker, David H.

doi:10.3382/ps.0501450

Cited by 43 publications

(15 citation statements)

References 8 publications

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“…In agreement with early research of Graber et al [44] and Moran [36], the effect of an elevated Cys to Met ratio was more obvious in the grower period of our current study. Our previous experiment [25] yielded a higher Met efficiency following Cys supplementation indicating a higher need for Cys due to increased feather plumage of older birds.…”

Section: Discussionsupporting

confidence: 94%

“…However, each increment in Cys supply demands an equal increment of Met in the diet [48]. Based on observations of Graber et al [44] with crystalline AA diets, the Cys requirement of chicken increases from 0.34% to 0.44% of the diet during the 2 nd and 8 th weeks of life. Accordingly, the relative contribution of Cys to the total SAA increased from 56% to 67% when BW gain or from 60% to 70% when gain/feed ratio were used as reference criterions.…”

Section: Discussionmentioning

confidence: 98%

“…For starter chicken, the optimal Cys contribution to SAA supply depending on diet composition (purified AA or practical type diets) and reference criterion (BW gain, feed efficiency or body protein deposition) was found to be between 48% and 58% [38], at 54% [43] or between 56% and 60% [44].…”

Section: Discussionmentioning

confidence: 99%

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An Elevated Dietary Cysteine to Methionine Ratio Does Not Impact on Dietary Methionine Efficiency and the Derived Optimal Methionine to Lysine Ratio in Diets for Meat Type Chicken

Kahn¹,

Wecke²,

Liebert³

2015

OJAS

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Optimal dietary methionine (Met) to lysine (Lys) ratio in presence of elevated dietary cysteine (Cys) levels was derived for meat type growing chicken. Twelve averaged weighed Ross 308 birds (each 50% of male and female per dietary treatment) were utilized in N balance trials. During starter (d10 -20) and grower period (d25 -35) five dietary treatments were used. Diets based on uniform mixtures of maize, wheat, soybean meal, potato protein and fish meal were supplemented with crystalline amino acids (AA). In diets 1 -3, the dietary Cys to Met ratio was set as 85, 95 and 105 to 100, respectively. Diet 4, at a Cys to Met ratio of 105 to 100, was additionally supplemented with betaine (BET) as methyl group donor. Diets 1 -4 were limiting in Met, diet 5 without L-Lys•HCl addition was limiting in Lys. Individual N-balance data per treatment were utilized for assessing protein quality and efficiency of dietary Met (Diets 1 -4) or Lys (Diet 5) based on "Goettingen approach". Elevated dietary Cys supply and supplemented BET failed to improve both dietary protein quality and Met efficiency. The established optimal Met to Lys ratio was on average 34 to 100 for growing chicken during starter and grower period, respectively.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 98%

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An Elevated Dietary Cysteine to Methionine Ratio Does Not Impact on Dietary Methionine Efficiency and the Derived Optimal Methionine to Lysine Ratio in Diets for Meat Type Chicken

Kahn¹,

Wecke²,

Liebert³

2015

OJAS

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“…Cysteine content is relatively higher for feather formation, creating differences in response to Cys [32]. In the current study, Met was used to supply TSAA content of the experimental diets and Met is involved in Cys synthesis [33]. The 3 0.67 0.60-0.74 0.03 0.001 1 95% CI of the estimated digestible TSAA to Lys ratio.…”

Section: Methodsmentioning

confidence: 99%

Ratio of digestible total sulfur amino acids to lysine of broiler chicks from 1 to 15 days of age

Dozier

Mercier²

2013

Journal of Applied Poultry Research

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“…It has been estimated that cysteine can supply up to 50% of the total sulfur amino acid requirement for rats [4,5], chicks [6] and pigs [7]. When diets contain adequate levels of both sulfur amino acids, the partitioning of Hcy between the remethylation and transsulfuration pathways has been estimated to be approximately equal in humans [8], perfused rat livers [9] and in vitro [10].…”

Section: Introductionmentioning

confidence: 99%

Inhibition of betaine-homocysteine S-methyltransferase in rats causes hyperhomocysteinemia and reduces liver cystathionine β-synthase activity and methylation capacity

et al. 2011

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Methylation of homocysteine (Hcy) by betaine-homocysteine S-methyltransferase (BHMT) produces methionine, which is required for S-adenosylmethionine (SAM) synthesis. We have recently shown that short term dietary intake of S-(-δ-carboxybutyl)-DL-homocysteine (CBHcy), a potent and specific inhibitor of BHMT, significantly decreases liver BHMT activity and SAM concentrations but does not have an adverse affect on liver histopathology, plasma markers of liver damage or DNA methylation in rats. The present study was designed to investigate the hypothesis that BHMT is required to maintain normal liver and plasma amino acid and glutathione profiles, and liver SAM and lipid accumulation. Rats were fed an adequate (4.5 g/kg methionine and 3.7 g/kg cystine), cysteine-devoid (4.5 g/kg methionine and 0 g/kg cystine), or methionine-deficient (1.5 g/kg methionine and 3.7 g/kg cystine) diet either with or without CBHcy for 3 or 14 d. All rats fed CBHcy had increased total plasma Hcy (2- to 5-fold), and reduced liver BHMT activity (>90%) and SAM concentrations (>40%). CBHcy treatment slightly reduced liver glutathione levels in rats fed the adequate or cysteine-devoid diet for 14 d. Rats fed the methionine-deficient diet with CBHcy developed fatty liver. Liver cystathionine β-synthase activity was reduced in all CBHcy-treated animals, and the effect was exacerbated as time on the CBHcy diet increased. Our data indicate that BHMT activity is required to maintain adequate levels of liver SAM and low levels of total plasma Hcy, and might be critical for liver glutathione and triglyceride homeostasis under some dietary conditions.

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Sulfur Amino Acid Nutrition of the Growing Chick: Effect of Age on the Capacity of Cystine to Spare Dietary Methionine

Abstract: availability of dietary zinc for turkey poults. J. Nutrition, 68: 313-322. Larsen, B. A., R. G. S. Bidwell and W. W. Hawkins, 1960. The effect of ingestion of ethylenediaminetetraacetate on the absorption and metabolism of radioactive iron by the rat. Can. J.

Cited by 43 publications

References 8 publications

An Elevated Dietary Cysteine to Methionine Ratio Does Not Impact on Dietary Methionine Efficiency and the Derived Optimal Methionine to Lysine Ratio in Diets for Meat Type Chicken

An Elevated Dietary Cysteine to Methionine Ratio Does Not Impact on Dietary Methionine Efficiency and the Derived Optimal Methionine to Lysine Ratio in Diets for Meat Type Chicken

Ratio of digestible total sulfur amino acids to lysine of broiler chicks from 1 to 15 days of age

Inhibition of betaine-homocysteine S-methyltransferase in rats causes hyperhomocysteinemia and reduces liver cystathionine β-synthase activity and methylation capacity

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