Sulfur (and Related Elements)–X Activation

The Palladium-Catalyzed Intermolecular C–H Chalcogenation of Arenes

“…The first method is based on the widely recognized cross-coupling reaction of organo halides with RZH or R 2 Z 2 (Z = S, Se) (Scheme (A)), which provides reliable routes to the formation of C–Z bonds . Another important approach to the formation of C–Z bonds involves the addition of Z–Z or Z–H or even C–Z bonds across unsaturated C–C bonds of alkynes or alkenes (Scheme (B)) . The third method is C–H bond functionalization (Scheme (C)). − In comparison with the first two well-established methods, C–S bond formation via C–H bond cleavage has not yet been well developed.…”

Regioselective Bis-Selenation of Allenes Catalyzed by Palladium Complexes: A Theoretical Study

“…In recent years, considerable attention has been focused on the transition-metal-catalyzed addition of group 16 heteroatom compounds to carbon−carbon unsaturated bonds due to the increasing demand for sulfur- and selenium-containing compounds in organic chemistry and materials science. − In the past few decades, group 16 heteroatom compounds were not largely developed, probably because these compounds had long been considered as catalyst poisons due to their strong interaction with catalysts . However, with the finding that, when catalyzed by palladium(0), disulfide and diselenide can add to carbon−carbon triple bonds to give the corresponding functional alkenes with high stereoselectivity, , more and more attention has been focused on the transition-metal-catalyzed addition of group 16 heteroatom compounds to unsaturated organic molecules.…”

Gold-Catalyzed Anti-Markovnikov Selective Hydrothiolation of Unactivated Alkenes

“…Transition-metal-catalyzed addition of heteroatom compounds is a very attractive strategy for the selective synthesis of heteroatom-functionalized molecules . Organosulfur compounds, for example, have widespread utility as synthetic intermediates, bioactive compounds, and functional materials .…”