Sulfur and selenium derivatives of quinazoline and pyrido[2,3-d]pyrimidine: Synthesis and study of their potential cytotoxic activity in vitro

Synthesis and Evaluation of Pyrido[2,3‐d]pyrimidine and 1,8‐Naphthyridine Derivatives as Potential Antitumor Agents

“…Pyridopyrimidine and its derivatives are an important group of heterocyclic compounds, which have been subject to extensive study in the past years because of a variety of chemical and biological significance. The importance of pyridopyrimidines as biologically active compounds includes their use as antitumor , antimicrobial , anti‐inflammatory , antimalarial , antifolate , anticonvulsant , analgesic , and antioxidant . In addition, pyridopyrimidine‐2‐thiones displayed potent activity against Mycobacterium tuberculosis H37Rv .…”

Vibrational spectra, conformational properties and argon matrix photochemistry of diacetyl diselenide, CH3C(O)Se2C(O)CH3

“…Chemical applications of diselenides arise mainly from the convenient inclusion of RSe units in both organic and inorganic synthesis by cleavage of the Se–Se bond; this is mostly influenced by the weaker dissociation energy of this bond in comparison with C–Se, H–Se and S–S bonds . Representative members of this family include (SePh) 2 and (CH 3 Se) 2 , which are compounds widely employed in organic reactions and catalysis because of the high yields achieved (>90%) for the inclusion of PhSe – and CH 3 Se – moieties, respectively …”

Recent advances in the chemistry and biology of pyridopyrimidines

“…The first step involved the condensation of 2-amino-cyanopyridine 123 with isoselenocyanates 122 in the presence of pyridine. Alkylation of the selenium atom with various alkyl iodides was performed to give library 125 (Scheme 37).Compound 127 exhibited a marked cytotoxic effect on leukemia CCFF-CEM, colon HT-29, lung HTB-54, breast MCF-7 cell lines and replacement of the sulfur by a selenium atom 126 did not significantly affect biological activity[41]. An increase in Caspase-3 activity accompanied by cell cycle perturbation in a time-dependent manner was demonstrated with the hydroselenite salt 128 (Scheme 38)[42].Malhotra et al investigated the synthesis of 4-substituted 2-amino pyrido[3,4-d]pyrimidine derivatives 129 as potential anticancer agents.…”