Sulfur containing activated hydantions. Synthesis and screening some novel benzylidenehydantoins amino acids derivatives

Abstract

5-Benzylidenehydantoin reacts with chlorosulfonic acid to give the corresponding p-sulfonyl chloride 1. Condensation with nucleophiles gives amino acid derivatives 2-7. Coupling reactions of some amino acid derivatives (2-6) with amino acid methyl ester hydrochloride in THF-Et3N medium using the dicyclohexylcarbodiimide method (DCC) furnish the desired dipeptidemethyl esters 8-12. The spectral data of the synthesized compounds are briefly discussed.

Novel Imides Amino Acids and Dipeptide Derivatives

“…The products were to be chromatographically homogeneous. (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17), (20)(21)(22)(23)(24)(25)(26)(27)(28)(29) and (32)(33)(34)(35)(36)(37)(38)(39)(40) 6.14 6.11…”