Sulfur-Containing Amides from Glycosmis Species (Rutaceae)

Hofer, Otmar; Greger, Harald

doi:10.1007/978-3-7091-6331-3_2

Cited by 8 publications

(4 citation statements)

References 65 publications

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“…These prenylated amides are mostly oxidised to sulfones or sulphoxides [11]. Apart from their chemotaxonomic importance, some sulphur-containing amides show pronounced antifungal or insecticidal activity [12].…”

Section: Discussionmentioning

confidence: 99%

High antitrypanosomal activity of plant-derived sulphur-containing amides

Astelbauer

Obwaller²,

Raninger

et al. 2010

International Journal of Antimicrobial Agents

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Section: Discussionmentioning

confidence: 99%

High antitrypanosomal activity of plant-derived sulphur-containing amides

Astelbauer

Obwaller²,

Raninger

et al. 2010

International Journal of Antimicrobial Agents

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“…G. pentaphylla is a perennial shrub indigenous to the tropical and subtropical regions of China, India, Sri Lanka, Bangladesh, Indonesia, Myanmar, Malaysia, Thailand, the Philippines, Java, Vietnam, Sumatra, Borneo, and Australia. , These plants are traditionally used to treat a variety of ailments including rheumatism, urinary tract infections, chest pain, anemia, cough, liver disorders, inflammation, pain, fever, jaundice, bronchitis, bone fractures, toothache, gonorrhea, diabetes, cancer, and other chronic diseases. , An extensive literature search on phytochemistry of G. pentaphylla revealed that various parts of this plant were reported to contain at least 354 secondary metabolites such as acridone, carbazole, quinolone, and quinazoline types of alkaloids, flavonoids, phenolic glycosides, quinones, furoquinolines, terpenoids, steroids, sulfur-containing amides, gums, reducing sugars, tannins, saponins, and fatty derivatives .…”

Section: Introductionmentioning

confidence: 99%

Isolation, Characterization of Undescribed Alkaloids, and Semisynthetic Modifications of Cytotoxic Pyranoacridone Alkaloids from Glycosmis pentaphylla

Teja

Shah

et al. 2023

ACS Omega

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Two undescribed alkaloids (10 and 11), along with nine known alkaloids (1–9), have been isolated from the stem and root bark of Glycosmis pentaphylla. Among them are carbocristine (11), a carbazole alkaloid first time isolated from a natural source, and acridocristine (10), a pyranoacridone alkaloid first time isolated from the genus “Glycosmis”. In vitro cytotoxicity of isolated compounds has been analyzed on breast cancer (MCF-7), lung cancer (CALU-3), and squamous cell carcinoma cell lines (SCC-25). The results demonstrated that compounds are moderately active. In order to study the structural activity relationship of majorly isolated compounds, semisynthetic modifications have been done on majorly isolated compounds such as des-N-methylacronycine (4) and noracronycine (1) to synthesize 11 semisynthetic derivatives (12–22) on functionalizable −NH and −OH groups of the pyranoacridone scaffold at 12th and 6th positions. Semisynthetic derivatives are explored on the same cell lines as isolated compounds, and the results exhibit that semisynthetic compounds showed potent cytotoxic activity compared with naturally isolated compounds. In the case of CALU-3, the dimer at −OH position of noracronycine (1), i.e., compound 22, showed 24-fold better activity with an IC50 of 4.49 μM compared with noracronycine (1) with IC50 97.5 μM. In MCF-7, the dimer at −OH position of noracronycine (1), i.e., compound 22, showed 14-fold better activity with an IC50 of 13.2 μM compared with noracronycine (1) with IC50 187 μM.

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“…Plants in this genus have a long history of usage as traditional medicine for treating a wide range of medical conditions (Khare, 2011). As previous research has shown, the Glycosmis genus contains quinazolines, furoquinolines (Yasir et al, 2019), carbazoles (Chakraborty, 2022), coumarins (Blanco Carcache et al, 2022), sulphur-containing amides (Hofer and Greger, 2000), quinolones, flavonoids and acridone-type alkaloids (Intekhab, et al, 2011), which have demonstrated to have broad-spectrum activity. The examination of pertinent scholarly works suggests that further investigation is required to explore the phytochemicals in Glycosmis mauritiana.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical And Antimicrobial Study of Glycosmis mauritiana (Lam.) Tanaka

KAMAL,

MEHREEN,

MUSAYEVA

et al. 2023

Fabad J Pharm Sci

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We have successfully extracted a novel geranyl flavanone from the root barks of Glycosmis mauritiana. The structucture was eleducated as 6-geranyl-5-hydroxy-3′ -methoxy-7, 8- (2", 2"-dimethyl pyrano) flavanone- 4'-O-D-glucopyranoside (GM-1), along with 3 known compounds (GM-2, GM-3, GM-4), was separated and identified by a variety of spectroscopic techniques. The range of inhibition against four bacteria examined was shown to be 4-25 mm; the GM-1 revealed a significant inhibition zone.

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Sulfur-Containing Amides from Glycosmis Species (Rutaceae)

Cited by 8 publications

References 65 publications

High antitrypanosomal activity of plant-derived sulphur-containing amides

High antitrypanosomal activity of plant-derived sulphur-containing amides

Isolation, Characterization of Undescribed Alkaloids, and Semisynthetic Modifications of Cytotoxic Pyranoacridone Alkaloids from Glycosmis pentaphylla

Phytochemical And Antimicrobial Study of Glycosmis mauritiana (Lam.) Tanaka

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