Sulfur-Doped NiFe Hydroxide Nanobowls with Wrinkling Patterns for Photothermal Cancer Therapy

Abstract

Hierarchical multiscale wrinkling nanostructures have shown great promise for many biomedical applications, such as cancer diagnosis and therapy. However, synthesizing these materials with precise control remains challenging. Here, we report a sulfur doping strategy to synthesize sub-1 nm NiFe hydroxide ultrathin nanosheets (S-NiFe HUNs). The introduction of sulfur affects the reduction of the band gap and the adjustment of the electronic structure, thereby improving the light absorption ability of the S-NiFe HUNs. Additionally, S-NiFe HUNs show a multilayered nanobowl-like structure that enables multiple reflections of incident light inside the nanostructure, which improved the utilization of incident light and achieved high photothermal conversion. As a result, the as-prepared product with hydrophilic modification (dS-NiFe HUNs) demonstrated enhanced tumor-killing ability in vitro. In a mouse model of breast cancer, dS-NiFe HUNs combined with near-infrared light irradiation greatly inhibited tumor growth and prolonged the mice survival. Altogether, our study demonstrates the great potential of dS-NiFe HUNs for cancer photothermal therapy applications.

Ameliorated Skin Inflammation through the Synergistic Effect of Gold Nanorod–Dexamethasone and Photothermal Therapy

“…Consequently, endeavors to augment the efficacy of AuNRs and drugs in cancer through the photothermal effect of laser irradiation have been steadily progressing . Furthermore, diverse examinations involving heat generated by gold irradiated with NIR and ultraviolet (UV) rays are ongoing in the medical field. − Based on these studies, gold nanorods and DX were synthesized in this study, and their therapeutic potential in skin inflammation was examined by irradiating them with a gold-reactive laser.…”

Biomimetic Photonic Elastomer Exhibiting Stress/Moisture Reconfigurable Wrinkle-Lattice for Reversible Deformation Information Storage

“…Wrinkled morphologies are ubiquitous in both artificial and natural systems. , In recent years, microto-nanoscale wrinkling has emerged as a straightforward and easily controllable surface modification technique. − It is often employed in conjunction with photonic soft materials to create structural colors or regulate microstructures . By dynamically adjusting the wrinkle state, films can achieve precise control over optical transmittance, angle dependence, visual angles, and hues of structural color. − It is worth noting that, based on the design of a bilayer system, the optical system can achieve intricate dynamic reconfiguration of wrinkles following stress stimuli .…”