Sulfur mustard analog 2-chloroethyl ethyl sulfide increases triglycerides by activating DGAT1-dependent biogenesis and inhibiting PGC1ɑ-dependent fat catabolism in immortalized human bronchial epithelial cells

Ye, Feng; Zeng, Qinya; Dan, Guorong; Zhao, Yuanpeng; Yu, Wenpei; Cheng, Jin; Chen, Mingliang; Wang, Bin; Zhao, Jiqing; Sai, Yan; Zou, Zhongmin

doi:10.1080/15376516.2022.2124898

Cited by 2 publications

(1 citation statement)

References 36 publications

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“…A-922500 (Abbott Laboratories, 2009) was tested in diet-induced rat models of hypertriglyceridemia at 3 mg/kg, reducing circulating TAGs and free fatty acids. This compound was also used to block lipid droplet formation in response to mustard gas in cell cultured human bronchial epithelial cells (Ye et al, 2023). GSK3008356, developed by GlaxoSmithKline and featuring an unrelated chemical structure, is a selective DGAT1 inhibitor developed to address non-alcoholic steatohepatitis (NASH).…”

Section: Pf-04620110 Was Developed By Pfizer Global Research and Deve...mentioning

confidence: 99%

Drug Targeting of Acyltransferases in the Triacylglyceride and 1-O-AcylCeramide Biosynthetic Pathways

Hernandez-Corbacho,

Canals

2023

Mol Pharmacol

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Acyltransferase enzymes (EC 2.3.) are a large group of enzymes that transfer acyl groups to a large variety of substrates. This review focuses on fatty acyltransferases involved in the biosynthetic pathways of glycerolipids and sphingolipids and how these enzymes have been pharmacologically targeted in their biological context. Glycerolipids and sphingolipids, commonly treated independently in their regulation and biological functions, are put together to emphasize the parallelism in their metabolism and bioactive roles.Furthermore, a newly considered signaling molecule, 1-O-acylceramide, resulting from the acylation of ceramide by DGAT2 enzyme, is discussed. Finally, the implications of DGAT2 as a putative Ceramide AcylTransferase (CAT) enzyme, with a putative dual role in TAG and 1-O-acylceramide generation, are explored.

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Section: Pf-04620110 Was Developed By Pfizer Global Research and Deve...mentioning

confidence: 99%

Drug Targeting of Acyltransferases in the Triacylglyceride and 1-O-AcylCeramide Biosynthetic Pathways

Hernandez-Corbacho,

Canals

2023

Mol Pharmacol

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HSP90/CDC37 inactivation promotes degradation of LKB1 protein to suppress AMPK signaling in bronchial epithelial cells exposed to sulfur mustard analog, 2-chloroethyl ethyl sulfide

Wang

Liu

et al. 2023

Chemico-Biological Interactions

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Sulfur mustard analog 2-chloroethyl ethyl sulfide increases triglycerides by activating DGAT1-dependent biogenesis and inhibiting PGC1ɑ-dependent fat catabolism in immortalized human bronchial epithelial cells

Cited by 2 publications

References 36 publications

Drug Targeting of Acyltransferases in the Triacylglyceride and 1-O-AcylCeramide Biosynthetic Pathways

Drug Targeting of Acyltransferases in the Triacylglyceride and 1-O-AcylCeramide Biosynthetic Pathways

HSP90/CDC37 inactivation promotes degradation of LKB1 protein to suppress AMPK signaling in bronchial epithelial cells exposed to sulfur mustard analog, 2-chloroethyl ethyl sulfide

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