1961
DOI: 10.1002/jps.2600501102
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Sulfurous Acid Salts as Pharmaceutical Antioxidants

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1963
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Cited by 35 publications
(9 citation statements)
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“…Mechanisms involving SOiT' radicals are also preferred by Barrie and Georgii (52) Still other mechanisms have been proposed involving 0 2 " and OH" radicals (18,34,53). Rate laws derived for these mechanisms predict a first-order dependence on sulphite concentration, and a pH dependence in agreement with experimental observations.…”
Section: Mechanismmentioning
confidence: 67%
“…Mechanisms involving SOiT' radicals are also preferred by Barrie and Georgii (52) Still other mechanisms have been proposed involving 0 2 " and OH" radicals (18,34,53). Rate laws derived for these mechanisms predict a first-order dependence on sulphite concentration, and a pH dependence in agreement with experimental observations.…”
Section: Mechanismmentioning
confidence: 67%
“…Differences in the activity of these analogs of acetylcholine have long been explained on the basis of molecular steric and electronic effects in the drug-receptor interaction (1,2). Spectral data concerned with conformational aspects of acetylcholine have also been studied and developed in recent attempts t o describe receptor site architecture (3)(4)(5)(6)(7).…”
Section: Resultsmentioning
confidence: 99%
“…The adverse influence of atmospheric oxygen on both the physical and chemical stability of parenteral formulations and the numerous problems arising from the oxidative decomposition of drugs in the development of new products has been emphasized repeatedly in the past (1)(2)(3)(4)(5)(6). The inclusion of a suitable antioxidant system to inhibit the oxidative process and the replacement of air in the headspace of a product's container with an inert atmosphere are generally recognized as considerable aids in stabilizing an injectable formulation.…”
mentioning
confidence: 99%
“…XIDATION OF AQUEOUS solutions of sulfurous 0 acid salts in the presence of air proceeds by a free radical chain mechanism; compounds capable of breaking the reaction chain serve as effective inhibitors of the oxidative process (1). Organic compounds in rather dilute solution (10-6 to 10-4 M) representing the following wide variety of classes are known to inhibit sulfite oxidation: acids (2), alcohols, glycols, mono-and polysaccharides (3)(4)(5)(6), amines (7-10).…”
Section: By Louis C Schroetermentioning
confidence: 99%