Sulphanilamide in Scarlet Fever

Benn, E. C.

doi:10.1136/bmj.2.4107.644

Cited by 7 publications

(2 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…23 Less dramatic effects of these new drugs were investigated under the aegis of the Committee in four alternate allocation trials done by Snodgrass and Anderson at Ruchill Hospital in Glasgow. 24 -27 However, the reports of a number of other studies which had used alternate allocation during the life of the Committee make no mention of MRC support (see, for example, Ellison, 28 Sutherland, 29 Moir, 30 Peters and Cullum, 31 Theobald, 32 Evans and Gaisford, 33 Johnstone, 34 Peters, 35 Benn, 36 and Price 37 ), although one did. 38 The initiation of well-designed, multicentre controlled trials under the aegis of the MRC recognition as the first well controlled multi-centre clinical trial to have been conducted under the aegis of the MRC'.…”

Section: What Did the Mrc Therapeutic Trials Committee Achieve?mentioning

confidence: 99%

The Medical Research Council and clinical trial methodologies before the 1940s: the failure to develop a ‘scientific’ approach

Bryder

2011

J R Soc Med

View full text Add to dashboard Cite

2007 monograph, Martin Edwards wrote that Fletcher 'repeatedly affirmed his conviction that medicine and therapeutics could only progress through fundamental scientific research, frequently performed by non-clinical scientists rather than clinicians'. 8,9 Edwards noted that this trend was reinforced in 1920 when the Medical Research Committee was separated from the Ministry of Health, and became the Medical Research Council, which was responsible to the Privy Council. The way in which the new Council distinguished itself from the Ministry of Health was through its laboratory-based research, with the National Institute of Medical Research at the centre of its operations. The two bodies reached an agreement in 1924: the Ministry of Health was to be concerned with 'applied research' relating to clinical problems; the MRC would initiate and organize all new research in the basic biomedical sciences. Fletcher argued that 'progress in physiology, biochemistry, and pathology was essential to the development of clinical practice'. 8,9

show abstract

Section: What Did the Mrc Therapeutic Trials Committee Achieve?mentioning

confidence: 99%

The Medical Research Council and clinical trial methodologies before the 1940s: the failure to develop a ‘scientific’ approach

Bryder

2011

J R Soc Med

View full text Add to dashboard Cite

show abstract

“…Ashley 3 stated recently that the treatment of choice for scarlet fever consists in giving both convalescent scarlet fever serum and penicillin. But on the basis of past experience we believe equally good results may be obtained by the use of convalescent scarlet fever serum alone.4 Other clinicians 5 have reported success with the sulfonamide compounds. However, in our opinion sul¬ fonamide drugs are not of value in overcoming the toxemia of scarlet fever.…”

Section: Addendummentioning

confidence: 97%