Sulphite‐corrected, non‐phenolic and phenolic antioxidant capacities of fruit wines profiled by differential Folin‐Ciocalteu assay

Zhang, Aihua; Zeng, Lingwen; Bo, Huijie; Hardie, Jim

doi:10.1111/ijfs.15510

Cited by 6 publications

(5 citation statements)

References 62 publications

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“…The total phenolics content of C. rotang ethyl acetate extract was determined by using gallic acid as a reference compound in Folin-Ciocalteu assay [ 21 ]. It contains 804 ± 0.18 mg Gallic Acid Equivalent (GAE)/100 g dry weight as shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

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Potent hepatoprotective activity of common rattan (Calamus rotang L.) leaf extract and its molecular mechanism

Anwar

Abdel-Maksoud

Sayed

et al. 2023

BMC Complement Med Ther

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Background Calamus rotang L. (CR) is an Indian shrub. The leaves and other organs of the plant are traditionally used in India for treatment of various diseases. The in vitro antioxidant property of the leaves extract was previously established. Thus, the current study aimed to evaluate the antioxidant and hepatoprotective effects of CR ethyl acetate extract at a dose of 350 mg/kg on CCl4 induced hepatotoxic rats through different mechanisms. Methods Histopathological examination of the treated rats’ group in comparison with positive and negative controls were performed. Quantitative measuring of the proinflammatory cytokines (TNF α), inflammatory regulators (Arginase, PPAR α) and the antiapoptotic protein Bcl-2 in comparison with positive and negative control groups was achieved using immunohistochemical examination. HPLC profiling of the polyphenol contents and molecular docking of the identified compounds against BH3 proapoptotic protein were correspondingly studied to evaluate the potential antiapoptotic property. Results The CR extract greatly protects the liver tissue through the suppression of TNF α, arginase and PPAR α induced by CCl4 as well as its enhancement of the antiapoptotic Bcl-2 protein. Fourteen polyphenols of different classes were identified in CR extract and tested via molecular docking for their potential antiapoptotic activities against BH3 protein. Naringin, rutin, 7-hydroxy flavone, and ellagic acid compounds exhibit the highest affinity and potential inhibition of pro-apoptotic protein BH3 via molecular docking study. Conclusions The ethyl acetate fraction of the leaves of C. rotang is rich in polyphenols that exhibited potent hepatoprotective effect on CCl4 induced hepatotoxic rats through its antioxidant, anti-inflammatory, anti-steatosis and antiapoptotic properties.

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Section: Resultsmentioning

confidence: 99%

“…The total phenolic content of CR extract was determined according to the method previously reported [ 21 ]. Briefly, gallic acid was used as a standard phenolic compound.…”

Section: Methodsmentioning

confidence: 99%

Potent hepatoprotective activity of common rattan (Calamus rotang L.) leaf extract and its molecular mechanism

Anwar

Abdel-Maksoud

Sayed

et al. 2023

BMC Complement Med Ther

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“…For total SO 2 , the typical value for white wines is between 37 and 59 mg/L [ 18 ], and for fruit-based (peach, blueberry, bayberry, dragon fruit, Chinese quince) wines. [ 24 ] reported a range from 22 to 51 mg/L for total SO 2 and between 3.2 and 13 mg/L for free SO 2 . Our results comply with the current regulations for white grape wines, suggesting that our melon wines are below the limits of total SO2 and with a proper content of free SO 2 for stabilizing melon wine for a long time.…”

Section: Resultsmentioning

confidence: 99%

Fruit Wine Obtained from Melon by-Products: Physico-Chemical and Sensory Analysis, and Characterization of Key Aromas by GC-MS

Salas-Millán

Aznar

Conesa

et al. 2022

Foods

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About 20% of fresh fruits and vegetables are rejected for not meeting the superficial aesthetic standards (color, shape, and size). Part of the food production is not used in the human food chain. The transformation of these fresh products into novel re-valuable ones is a challenge for a sustainable food industry. This research studies an alcoholic fermentation fruit-based wine from two melon (Cucumis melo L.) cultivars: Jimbee® (smooth and yellow skin with orange flesh) and Okashi® (netted yellow-orange skin with pale green flesh). The melon juice (must) was fermented by Saccharomyces cerevisiae and enriched in sucrose and organic acids to achieve alcoholic fermentation, acidity, and flavors, obtaining a fruity-flavored and dry melon-based wine with 10° alcoholic grade, in both melon cultivars. The volatile compounds were measured by GC-MS and the odor activity value (OAV) was calculated. The Jimbee and Okashi melon wines increased their aromatic profile due to an increment in medium-chain fatty acid ethyl esters such as ethyl hexanoate, ethyl octanoate, and ethyl decanoate (OAV > 1), which contributed to the fruity aroma. Other volatile compounds such as ethyl 9-decenoate and phenethyl acetate (OAV > 1) appeared in the Okashi wine, which brought a floral aroma. For sensory evaluation (40–100), the Jimbee cultivar, with its orange flesh, scored 68.2 and the Okashi cultivar, with pale green flesh, scored 82.8, which was the preferred melon-based wine. This is an example of a circular economy model to produce a fruit-based wine with commercial potential and satisfactory sensory evaluation.

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“…Gallic acid was used as standard and for the calculation of the percentage of inhibition the following relation was used: %Inhibition = [Blank − Test]/Blank × 100. A second test to evaluate the antioxidant activity was carried out through the determination of total phenols by the ABTS and Folin–Ciocalteu technique, according to the methodology previously reported [ 28 , 29 , 30 , 31 ]. The same doses mentioned above were used for the test, and the results were reported as equivalents of gallic acid.…”

Section: Methodsmentioning

confidence: 99%

Cymbopogon citratus Essential Oil: Extraction, GC–MS, Phytochemical Analysis, Antioxidant Activity, and In Silico Molecular Docking for Protein Targets Related to CNS

Cortes-Torres,

López-Castillo,

Marín-Torres

et al. 2023

CIMB

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This study analyzed the chemical composition of Cymbopogon citratus essential oil from Puebla, México, assessed its antioxidant activity, and evaluated in silico protein–compound interactions related to central nervous system (CNS) physiology. GC–MS analysis identified myrcene (8.76%), Z-geranial (27.58%), and E-geranial (38.62%) as the main components, with 45 other compounds present, which depends on the region and growing conditions. DPPH and Folin–Ciocalteu assays using the leaves extract show a promising antioxidant effect (EC50 = 48.5 µL EO/mL), reducing reactive oxygen species. The bioinformatic tool SwissTargetPrediction (STP) shows 10 proteins as potential targets associated with CNS physiology. Moreover, protein–protein interaction diagrams suggest that muscarinic and dopamine receptors are related to each other through a third party. Molecular docking reveals that Z-geranial has higher binding energy than M1 commercial blocker and blocks M2, but not M4 muscarinic acetylcholine receptors, whereas β-pinene and myrcene block M1, M2, and M4 receptors. These actions may positively affect cardiovascular activity, memory, Alzheimer’s disease, and schizophrenia. This study highlights the significance of understanding natural product interactions with physiological systems to uncover potential therapeutic agents and advanced knowledge on their benefits for human health.

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Sulphite‐corrected, non‐phenolic and phenolic antioxidant capacities of fruit wines profiled by differential Folin‐Ciocalteu assay

Cited by 6 publications

References 62 publications

Potent hepatoprotective activity of common rattan (Calamus rotang L.) leaf extract and its molecular mechanism

Potent hepatoprotective activity of common rattan (Calamus rotang L.) leaf extract and its molecular mechanism

Fruit Wine Obtained from Melon by-Products: Physico-Chemical and Sensory Analysis, and Characterization of Key Aromas by GC-MS

Cymbopogon citratus Essential Oil: Extraction, GC–MS, Phytochemical Analysis, Antioxidant Activity, and In Silico Molecular Docking for Protein Targets Related to CNS

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