Sulphonated biomaterials as glycosaminoglycan mimics in wound healing

Tighe, Brian; Mann, Aisling

doi:10.1533/9780857093301.2.321

Cited by 11 publications

(3 citation statements)

References 36 publications

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“…The ease of sulphonation of a synthetic polymer enables good remodelling and reconstruction of the impaired tissues and act as active wound dressing material in the form of sulphopropyl agaroses and dextrans. Maintenance of an acceptable level of sulphonation in ocular applications can reduce discomfort and hypertonicity in tear films [24]. Cross links in the sulphonated polymeric chains can effectively enhance their mobility acting as heparin mimics,healing an exuding wound effectively [25].…”

Section: Introductionmentioning

confidence: 99%

Strategically designed SPEEK nanofibrous scaffold with tailored delivery of resveratrol for skin wound regeneration

Ekambaram¹,

Saravanan²,

Dharmalingam³

2022

Biomed. Phys. Eng. Express

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Electro-spinnable polymeric materials can easily form two-dimensional (2D) nanofibrous scaffolds improving biochemical functionalities specially in the area of skin wound healing and nanomedicine, but it has been hard to achieve this on a highly mechanically stable biopolymer, Poly ether ether ketone (PEEK), due to its intrinsic hydrophobicity and chemical inertness. Herein, we demonstrated a novel nanomedicine healing system consisting of sulphonated poly ether ether ketone combined with resveratrol (SPEEK+RSV), which could act as an effective 2D nano bio-material in vitro and in vivo, without observable cytotoxicity. The fabricated nanocomposites exhibited enriched skin cell proliferation and adhesion as confirmed from the results of MTT, cell adhesion and live-dead assay. Results of SEM analysis showed a uniform nano-sized distribution with adequate pore size and porosity % facilitating a desired breathable environment at the wound site. The results of FT-IR, tensile studies and TGA analyses confirmed the presence of appropriate bonds and improved mechanical stability of the RSV incorporated nanofibrous scaffold. Results of anti-microbial analysis portrayed good potentiality of the fabricated nanofibers in treating wounds colonized with bacterial infections. Controlled drug release of resveratrol established the bio-compatibility of the nanofibers in skin wound regeneration. In vivo analysis assessed in female Wistar rats enabled complete wound closure with 100 % wound contraction within 16 days. Results of histopathology analysis through H-E and MT staining presented the re-surfing of the wound environment with regeneration of epithelium, granulation tissue and collagen. Thus, the fabricated 2D nanofibrous scaffold incorporated with pharmaceutical RSV bio-medicine perceptively mimicked skin ECM convincingly aiding the progression of skin wound regeneration mechanism.

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Section: Introductionmentioning

confidence: 99%

Strategically designed SPEEK nanofibrous scaffold with tailored delivery of resveratrol for skin wound regeneration

Ekambaram¹,

Saravanan²,

Dharmalingam³

2022

Biomed. Phys. Eng. Express

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“…The hydrogel wound dressing composed of sodium salt of 2-acrylamido-2-methylpropanesulfonate (Na-AMPS) has been extensively considered as biomimetic monomer because it offers the potential to mimic the role of the natural system namely, glycosaminoglycan which is an important molecule in wound healing process [11][12][13]. As shown in figure 1(a), the structure of Na-AMPS contains sulfonate group which plays role in water binding with the natural tissue and, subsequently, serves to maintain moist wound environment in the wound healing step [11,14,15]. Therefore, Na-AMPS was designed for use as based network of wound dressing material fabricated in this research.…”

Section: Introductionmentioning

confidence: 99%

Sodium 2-acrylamido-2-methylpropanesulfonate/gelatin hydrogels for use as wound dressings: preparation, characterization and cytocompatibility

Kapanya

Somsunan

Molloy

et al. 2019

Biomed. Phys. Eng. Express

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In this research, hydrogel for biomedical use as a wound dressing was consisted of sodium 2-acrylamido-2-methylpropanesulfonate (Na-AMPS) and gelatin with different compositions by UV-photoinitiation. It was found that this method gave high percentage of gel fraction. The hydrogels were characterized by Fourier-transform infrared spectroscopy, scanning electron microscopy and gel fraction, water transport, mechanical and cytocompatibility studies. As increasing of gelatin ratio, it increased water content, swelling ratio and water vapor transmission rate. The mechanical property results confirmed that gelatin improved mechanical properties of the hydrogels, presented in terms of stress and percent strain of the hydrogel. Furthermore, cytocompatibility studies demonstrated that all prepared hydrogels are not cytotoxic and gelatin also supports cell growth. These investigations indicated that the synthesized Na-AMPS and gelatin hydrogels are promising candidates for use as wound dressings and can be immediately applied to the wound without any harm.

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“…Los proteoglicanos confieren resistencia mecánica a la compresión, hidratación de los tejidos y llenado de espacios, proteoglicanos y glucosaminoglucanos también desempeñan funciones biológicas ya que pueden almacenar factores de crecimiento y citocinas. Además, glucosaminoglucanos como el ácido hialurónico tienen dominios para proteínas de adhesión celular (como CD44 y RHAMM) y otros componentes de la ECM [1,24,[29][30][31][32][33][34]. Uno de los principales objetivos en la investigación moderna de biomateriales es reclutar la organización nativa de la ECM en la superficie del biomaterial [1].…”

Section: Células Y Su Entornounclassified

Estudio sobre la interacción de nanopartículas polimerizadas por plasma con sistemas celulares

Uribe Juárez

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Sulphonated biomaterials as glycosaminoglycan mimics in wound healing

Cited by 11 publications

References 36 publications

Strategically designed SPEEK nanofibrous scaffold with tailored delivery of resveratrol for skin wound regeneration

Strategically designed SPEEK nanofibrous scaffold with tailored delivery of resveratrol for skin wound regeneration

Sodium 2-acrylamido-2-methylpropanesulfonate/gelatin hydrogels for use as wound dressings: preparation, characterization and cytocompatibility

Estudio sobre la interacción de nanopartículas polimerizadas por plasma con sistemas celulares

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