Sulphur isosters of carcinogenic hydrocarbons

Thiophene Compounds of Biological Interest

“…The key thioster XLVIIa, wherein both the PB's are removed, proved highly carcinogenic, contrary to the expectation that it would be inactive (176). When one of the two PB's in 9,lO-dimethyl-1 : 2,7 : 8-dibenzanthracene (XLVIII) was replaced, a highly active carcinogen XLV resulted as expected (177). However, the key thioster…”