Sulphurous medicinal waters increase somatostatin release: It is a possible mechanism of anti-inflammatory effect of balneotherapy in psoriasis

Boros, Melinda; Kemény, Ágnes; Sebők, Béla; Bagoly, Teréz; Perkecz, Anikó; Petőházi, Zoltán; Maász, Gábor; Schmidt, J.; Márk, László; László, Terézia; Helyes, Zsuzsanna; Szolcsányi, Janós; Pintér, Erika

doi:10.1016/j.eujim.2012.09.005

Cited by 20 publications

(15 citation statements)

References 42 publications

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“…In response to 21-day treatment of patients with psoriasis with sulfur medicinal water, dermal pool of dendritic cells almost disappeared and the epidermal populations of Langerhans cells showed normal distribution. Plasma concentration of somatostatin in psoriatic patients was higher than in healthy volunteers, and its level showed a further increase in response to bath treatment (18).…”

Section: Impact Of Balneotherapy Factors On the Skinmentioning

confidence: 96%

Balneotherapy of Psoriasis

Golušin

Jovanović

Jeremić

et al. 2014

Serbian Journal of Dermatology and Venereology

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Application of different kinds of mineral waters and peloids on the skin exerts mechanical, thermal and chemical effects. Significant reduction of inflammation and increased differentiation of keratinocytes may explain why balneotherapy has positive clinical effects in psoriatic patients. In vitro models have shown that thermal water stimulates interleukin-2 production after cell stimulation by staphylococcal enterotoxin B, and reduces interleukin-4 secretion. After balneotherapy, a significant decrease in Psoriasis Area Severity Index (PASI), associated with a significant reduction of interleukin-8, Staphylococcus aureus colonization and enterotoxin N, have been reported in patients with psoriasis. Mineral water was found to have inhibitory in vitro effects on substance P, TNF-α release and antigen-induced cell degranulation. Immunomodulatory effects of water depend on its content. Sulfur waters have beneficial anti-inflammatory, keratolytic, and antipruriginous effects and also possess antibacterial and antifungal properties. The effectiveness of balneotherapy in the treatment of psoriasis has been reported in many studies conducted all over the world. The majority of studies were conducted at the Dead Sea coast. Investigations showed that balneotherapy factors are important therapeutic factors in the treatment of psoriatic patients. The first and only comparable study of this kind in Serbia, was conducted in Prolom Spa with satisfactory therapeutic results.

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Section: Impact Of Balneotherapy Factors On the Skinmentioning

confidence: 96%

Balneotherapy of Psoriasis

Golušin

Jovanović

Jeremić

et al. 2014

Serbian Journal of Dermatology and Venereology

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“…Psoriasis is a recurrent and chronic inflammatory disease with a prevalence of 0.5–4.6% in different regions. In addition to physical effects, it is accompanied by social and emotional complications and causes significant disability (Ahlehoff et al, ; Azfar & Gelfand, ; Boros et al, ; Duarte & Chehin, ; Qiu, Zhu, Jia, Chen, & Meng, ). There is no definitive cure for psoriasis (Golusin et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…There is no definitive cure for psoriasis (Golusin et al, ). Symptoms can be treated with topical, systemic, or biological therapies (Boros et al, ; Péter et al, ), and there are side effects to these options (Bruner, Feldman, Ventrapragada, & Fleischer, ; Davis, ; Duarte & Chehin, ). Balneotherapy or the use of mineral waters or clays can be proposed as an alternative, safe, and natural treatment (Boros et al, ; Golusin et al, ).…”

Section: Introductionmentioning

confidence: 99%

Use of mineral waters in the treatment of psoriasis: Perspectives of Persian and conventional medicine

Khalilzadeh

Shirbeigi

Naghizadeh

et al. 2019

Dermatologic Therapy

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Psoriasis is a chronic inflammatory disease, which is accompanied by social and emotional complications leading to considerable disability. There is no definitive cure and treatment options carry complications. Balneotherapy has been used for years in psoriasis. Antibiotic, keratolytic, and anti‐inflammatory effects of these waters have been proved. Persian medicine (PM) is a source of natural remedies for skin disease. The aim of study is to explain scientific evidences of Persian mineral waters as a treatment option for psoriasis. This is a narrative review, which investigates medical manuscripts of medieval Persia from 10th to 19th centuries AD noted as credible textbooks about mineral waters. Furthermore, balneotherapy evidences searched in databases including Pubmed, Scopus, and Cochrane until December 2017 to obtain clinical evidences related to psoriasis. In PM, mineral waters have keratolytic activity and can regulate superficial skin layers hyperproliferation, which is recommended for psoriasis treatment. In various studies, antiproliferative, keratolytic, antibiotic, anti‐inflammatory, and antioxidant effects of these waters have been proved completely. There are scientific evidences, which demonstrate that mineral waters in Persia, can reduce clinical symptoms of psoriasis and improve quality of life in patients. Therefore, this method might be considered as treatment options for psoriasis.

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“…In a study published in 2013 the effect of sulphurous medicinal water in a murine dermatitis model and on psoriatic patients was observed. The results provided evidence that somatostatin released by hydrogen sulfide plays role in the mechanism of action of sulphurous medicinal water [47]. The thermal stress has an immunosuppressive effect.…”

Section: Assumed Mechanism Of Action Of Hydro-and Balneotherapymentioning

confidence: 66%

Efficacy of balneotherapy on pain, function and quality of life in patients with chronic low back pain, and hand or knee osteoarthritis

Kulisch¹

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Sulphurous medicinal waters increase somatostatin release: It is a possible mechanism of anti-inflammatory effect of balneotherapy in psoriasis

Cited by 20 publications

References 42 publications

Balneotherapy of Psoriasis

Balneotherapy of Psoriasis

Use of mineral waters in the treatment of psoriasis: Perspectives of Persian and conventional medicine

Efficacy of balneotherapy on pain, function and quality of life in patients with chronic low back pain, and hand or knee osteoarthritis

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