Sum-Frequency Generation Vibrational Spectroscopy: A Nonlinear Optical Tool to Probe the Polymer Interfaces

Kaur, Harpreet; Tomar, Deepak; Kaur, Harsharan; Rana, Bhawna; Chaudhary, Shilpi; Jena, Kailash C.

doi:10.1007/978-981-15-0202-6_3

Cited by 9 publications

(9 citation statements)

References 54 publications

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“…We used SFG spectrometer (Ekspla, Lithuania) to probe the drug–polymer interactions at the air–aqueous interface. The SFG experimental setup used for the present work is described previously in detail. − It is comprised with a passively mode-locked Nd:YAG laser (Ekspla PL2231). The output of the laser beam consisted of 30 ps pulse with a repetition rate of 50 Hz at a wavelength as 1064 nm with energy as 40 mJ.…”

Section: Methodsmentioning

confidence: 99%

“…SFG is a second-order nonlinear optical spectroscopic technique used to examine various interfaces to provide the molecular level insight about various interactions and the interfacial structure of the molecules residing at the interfacial region. − The SFG signal (ω SFG ) is generated after fulfilling the spatial and temporal overlapping of two input beams visible (ω VIS ) and the tunable infrared (IR) (ω IR ) at the air–aqueous interface. A schematic representation of SFG spectroscopy is given in Figure .…”

Section: Theoretical Considerationsmentioning

confidence: 99%

“…The nonlinear susceptibility (χ (2) ) is given as where A q , ω IR , ω q , and Γ q represent the amplitude of the q th mode of vibration, the frequency of the tunable IR beam, the frequency of the normal modes of vibration of the molecule, and the line width of the transition, respectively. , …”

Section: Theoretical Considerationsmentioning

confidence: 99%

“…where A q , ω IR , ω q , and Γ q represent the amplitude of the qth mode of vibration, the frequency of the tunable IR beam, the frequency of the normal modes of vibration of the molecule, and the line width of the transition, respectively. 24,27 Vibrational spectroscopy is ideal to identify the hydrogen bond strength due to the effect of intermolecular O−H•••O hydrogen bonding on the intermolecular O−H stretch vibration. The vibrational spectrum reveals the distribution of hydrogen bond strength and its modulation by intermolecular dynamics reflecting the nature of the local hydrogen bonding interactions.…”

Section: ■ Theoretical Considerationsmentioning

confidence: 99%

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Elucidating the Molecular Mechanism of Drug–Polymer Interplay in a Polymeric Supersaturated System of Rifaximin

et al. 2021

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Supersaturated drug delivery system (SDDS) enables the solubility and sustained membrane transport of poorly water-soluble drugs. SDDS provides higher drug concentration in the dispersed phase and equilibrium in the continuous phase, which corresponds to amorphous solubility of the drug. Rifaximin (RFX) is a nonabsorbable BCS class IV drug approved for the treatment of irritable bowel syndrome and effective against Helicobacter pylori. RFX shows slow crystallization and precipitation in an acidic pH of 1.2−2, leading to obliteration of its activity in the gastrointestinal tract. The objective of the present study is to inhibit the precipitation of RFX, involving screening of polymers at different concentrations, using an in-house developed microarray plate method and solubility studies which set forth hydroxypropyl methylcellulose (HPMC) E15, Soluplus, and polyvinyl alcohol to be effective precipitation inhibitors (PIs). Drug− polymer precipitates (PPTS) are examined for surface morphology by scanning electron microscopy, solid-phase transformation by hot stage microscopy, the nature of PPTS by polarized light microscopy, and drug−polymer interactions by Fourier transform infrared and nuclear magnetic resonance spectroscopy. Besides, the unfathomed molecular mechanism of drug−polymer interplay is discerned at the air−water interface using sum-frequency generation spectroscopy to correlate the interfacial hydrogen bonding properties in bulk water. Surprisingly, all studies disseminate HPMC E15 and Soluplus as effective PIs of RFX.

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Section: Methodsmentioning

confidence: 99%

Section: Theoretical Considerationsmentioning

confidence: 99%

Section: Theoretical Considerationsmentioning

confidence: 99%

Section: ■ Theoretical Considerationsmentioning

confidence: 99%

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Elucidating the Molecular Mechanism of Drug–Polymer Interplay in a Polymeric Supersaturated System of Rifaximin

et al. 2021

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“…It has been well established that the molecular structure of polymers may be substantially altered according to the adjacent solution conditions. − For such studies, the nonlinear vibrational technique of visible–infrared sum frequency generation (SFG) offers molecular fingerprints of buried polymer–aqueous interfaces and the ability to characterize the orientation of specific surface functional groups. SFG spectroscopy has therefore been valuable in characterizing the surface of polydimethylsiloxane (PDMS) films in their native state and under different treatment conditions. − …”

Section: Introductionmentioning

confidence: 99%

Algae Adhesion onto Silicone is Sensitive to Environment-Induced Surface Restructuring

et al. 2021

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Resistance to algae contamination is an important characteristic of insulators used in overhead power distribution in coastal environments. It is therefore important to understand the parameters governing algae adhesion onto polymer insulator materials such as silicone. Flow cell-based shear experiments were conducted in order to characterize the adhesion strength of algae onto polydimethylsiloxane surfaces, comparing fresh polymer substrates with those that have been soaked in water and saline solutions for 1 month. Both freshwater algae and seawater species could withstand considerably less drag force and were therefore more easily removed when the polymer was soaked in salt water. The polymer surface was found to be unaltered in terms of its roughness, contact angle, and lack of water uptake; no macroscopic surface characterization was therefore able to account for the differences in cell adhesion strength resulting from the soaking treatment. Surface-specific nonlinear vibrational spectroscopy, however, revealed subtle differences in the orientation of surface methyl groups that resulted from the water and saline exposure.

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Multifunctional Receptor with Tunable Selectivity: A Comparative Recognition Profile of Organic Nanoparticles with Carbon Dots

Kaur

Singh

et al. 2020

Chemistry An Asian Journal

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The exponential growth in the research field of water pollution control demands the evolution of novel sensing materials for regulation and quantification of metals ions. Within this context, the current work reports a new strategy for the synthesis of carbon dots from the hydrothermal treatment of organic nanoparticles. The organic nanoparticles are found to be selective towards Cs(I) ions with a detection limit of 5.3 nM, whereas the highly fluorescent carbon dots are found to be selective towards Ag(I) ions with a detection limit of 4.8 nM. Both sensing systems illustrate rapid sensing with a working pH range from 4–9. The interfacial molecular restructuring of the sensing systems in the aqueous phase has been investigated in the absence and presence of targeted metal ions using a sum frequency generation vibrational spectroscopic tool. The practical applicability of the sensors was checked in environmental samples. This work opens new avenues for the exploration of temperature‐guided sensing modulation in nanomaterials.

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Sum-Frequency Generation Vibrational Spectroscopy: A Nonlinear Optical Tool to Probe the Polymer Interfaces

Cited by 9 publications

References 54 publications

Elucidating the Molecular Mechanism of Drug–Polymer Interplay in a Polymeric Supersaturated System of Rifaximin

Elucidating the Molecular Mechanism of Drug–Polymer Interplay in a Polymeric Supersaturated System of Rifaximin

Algae Adhesion onto Silicone is Sensitive to Environment-Induced Surface Restructuring

Multifunctional Receptor with Tunable Selectivity: A Comparative Recognition Profile of Organic Nanoparticles with Carbon Dots

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