Sumatriptan Induced Takotsubo Cardiomyopathy; the Headache of the Heart: A Case Report

Abstract

Takotsubo Cardiomyopathy (TCM) is an increasing recognized form of acute reversible left ventricular systolic dysfunction not related to obstructive coronary disease. The exact physiology of this disorder is not yet known, however multiple agents have been hypothesized to have a link to this condition. Most commonly, TCM has been hypothesized as being triggered by a catecholamine surge after an inciting event. New evidence now suggests certain medications as a link to the disease. We describe a unique case of TCM in a woman after taking Treximet (naproxen and sumatriptan) as abortive therapy for a migraine.

Heart Break or Headache: A Case Report of Sumatriptan-Induced Takotsubo Syndrome

“…There are very few cases that report TS secondary to medications. Sumatriptan is the most common migraine abortive that has been mentioned to be associated with TS induction [ 3 , 4 ]. One case has reported zolmitriptan induction, and another case has reported rizatriptan [ 5 , 6 ].…”

“…A leading hypothesis of TS postulates that catecholamine exerts a major role [1,2]. There have been few cases that have reported TS secondary to triptan class administration, with sumatriptan as the most frequent drug of class to be mentioned [3][4][5][6].…”