yogenic granuloma (PG), also known as lobular capillary hemangioma, is a common acquired vascular lesion that occurs on skin and mucosal surfaces, particularly in the pediatric population. Timolol is a nonselective β-blocker that has been an effective nonsurgical alternative in treating pyogenic granulomas in a handful of case reports. [1][2][3][4][5][6] Most of these reports show the efficacy of timolol in nonocular PGs, with 1 case report 1 showing incidental resolution of an ocular surface PG 6 months after initiation of topical timololdorzolamide for glaucoma. To our knowledge, there are no reports examining the response of ocular surface PGs to topical β-blockers. Herein, we report a case series of ocular surface PGs of varying etiologies showing complete resolution with topical timolol treatment.
MethodsThis study adhered to the tenets of the Declaration of Helsinki. The Boston Children's Hospital Institutional Review Board approved the retrospective review of patient records, and informed consent was waived, given the retrospective nature of this study and the fact that all patient identifiers were omitted from analysis and from publication. We identified and included all patients with PG who were treated with topical timolol, 0.5%, between 2014 and 2016 through faculty survey (A.S.S. and R.A.P.) and billing records. We retrospectively reviewed patient medical records to abstract age, etiology, morphology, size, photography, treatment modality, outcome, and follow-up.