Summary of the II International Symposium on Cytomegalovirus

Jong, Menno D. de; Galasso, George J.; Gazzard, Brian; Griffiths, Paul; Jabs, Douglas A.; Kern, Earl R.; Spector, Stephen A.

doi:10.1016/s0166-3542(98)00044-8

Cited by 152 publications

(140 citation statements)

References 125 publications

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“…As previously described, several epidemiological factors including age, parity numbers, number of gestations, geographical distribution, socioeconomic provinceus, marital provinceus and sexual maturity may contribute to hCMV seroprevalence in women of child bearing age (Pal et al, 1972;Gambarroto et al, 1977;Mathur et al, 1981;Venkitaraman et al, 1986;Griffiths et al, 1991;Wen et al, 1996;De Jong et al, 1998;Gratacap et al, 1998;Hizel et al, 1999).…”

Section: Discussionmentioning

confidence: 97%

Human cytomegalovirus infection in women of childbearing age throughout Fars Province - Iran: a population-based cohort study

Arabpour¹,

Kaviyanee²,

Jankhah³

et al. 2007

MJM

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Human cytomegalovirus (hCMV) has been described as an important etiological agent of intrauterine infection in women of childbearing age that causes congenital malformation. In the present study we examined 844 serum samples from women of child-bearing age for the presence of IgM and IgG antibodies against hCMV by Elisa technique. 764 out of 844 (93%) of the cases were seropositive for hCMV-IgG and 45 (5.4%) cases were seropositive for hCMV-IgM. An increase in the rate of IgG seroprevalance was associated with an increase in age and parity. The IgG seroprevalance rate was inversely proportional to increasing abortions. Intrestingly seasonal variation affected IgG seroprevalance. There was an increasing trend in IgM positivity rate with age in women less than 29 years. hCMV seroprevalence rate was higher in women from rural as compared to those of urban areas. Finally hCMV primary infections occured in 2.4 % of all pregnancis and it is estimated that up to 0.3% of all congenital disorders, through out Fars province, were due to hCMV. We suggest a role of child to mother hCMV transmission and sexual maturity as the most probable epidemiological factors of hCMV seroprevalence among women of child bearing age.

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Section: Discussionmentioning

confidence: 97%

Human cytomegalovirus infection in women of childbearing age throughout Fars Province - Iran: a population-based cohort study

Arabpour¹,

Kaviyanee²,

Jankhah³

et al. 2007

MJM

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“…Although infection with CMV often passes undiagnosed because of its asymptomatic properties, the virus remains persistent in the host's cells for life. Adequate cell-mediated immunity is important for maintaining the virus in this chronic state (14,15). Importantly, CMV has been linked to inflammatory processes, cardiovascular disease, cognitive outcomes, and Alzheimer's disease (11,(16)(17)(18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

Socioeconomic disparities in the seroprevalence of cytomegalovirus infection in the US population: NHANES III

2008

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SummaryThere is a strong relationship between socioeconomic status (SES) and health outcomes in the U.S, though the mechanisms are poorly understood. Increasing evidence points to links between lifelong exposure to infectious disease and subsequent chronic disease. Exposure and susceptibility to infections may be one way SES affects long-term health, though little populationbased research to date has examined social patterning of infections in the U.S. This paper tests the relationship between income, education, race/ethnicity and seroprevalence of cytomegalovirus (CMV) infection at different ages in a representative sample of the U.S. population, and tests potential mediators for these relationships. The study finds significant racial and socioeconomic disparities in CMV seroprevalence beginning at early ages and persisting into middle age. Potential exposures do not explain the relationship between socioeconomic status and CMV positivity. Because reactivation of latent CMV infections may contribute to chronic disease and immune decline later in life, future research should determine the exposure or susceptibility pathways responsible for these disparities in the prevalence of CMV infection.

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“…Finally, a viral aetiology should be considered on the basis of the lymphocytic infiltrates and, to some extent, presence of autoimmune antibodies [8]. However, of the two viruses most often associated with cholestatic liver disease; HCV and CMV, serology for both were negative and CMV infections of the liver tend not to persist beyond 6 months in immune competent hosts [9]. Nonetheless, other viral pathogens such as betaretroviruses and Reovirus serotype 3 which have been implicated in the pathogenesis of human cholestatic disorders should be considered and excluded in future studies [10,11].…”

Section: Discussionmentioning

confidence: 99%

Adult idiopathic cholestasis: a condition more common in the Canadian Inuit?

Minuk

Pollock

Uhanova

2017

International Journal of Circumpolar Health

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Despite extensive investigations, some patients have no identifiable cause for their cholestatic liver enzyme abnormalities. The aim of this study was to document the clinical, laboratory, radiologic and histologic features of adult patients with idiopathic cholestasis (AIC). A computerised database of referred patients to a tertiary care hospital outpatient department for assessment of hepatobiliary disorders between 2005 and 2015 was employed to identify and describe features associated with AIC. Of 6,560 patient referrals, sufficient documentation to warrant a diagnosis of AIC was present in 17 (0.26%) cases. Of the 17, a disproportionate number were Canadian Inuit (7/60, 12% Inuit referrals vs. 10/6,500, 0.16% non-Inuit referrals, p<0.0001). The median age of the 17 subjects was 57 years and nine (53%) were female. Clinical and/or laboratory evidence of autoimmune disorders was present in six (35%) cases. Clinical features of hepatic decompensation, radiologic findings in keeping with cirrhosis and histologic confirmation of cirrhosis were present in 47%, 31% and 42% of individuals, respectively. There were no significant improvements in cholestatic liver enzymes and function tests in those treated with ursodiol and/or immunomodulants (n=7) compared to those left untreated (n=10). In conclusion, AIC is a rare condition diagnosed by exclusion. It appears to be more common in the Canadian Inuit population and those with autoimmune disorders. Advanced liver disease is a frequent finding at presentation. Intervention with ursodiol and/or immunomodulants does not appear to be of therapeutic value.

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Summary of the II International Symposium on Cytomegalovirus

Cited by 152 publications

References 125 publications

Human cytomegalovirus infection in women of childbearing age throughout Fars Province - Iran: a population-based cohort study

Human cytomegalovirus infection in women of childbearing age throughout Fars Province - Iran: a population-based cohort study

Socioeconomic disparities in the seroprevalence of cytomegalovirus infection in the US population: NHANES III

Adult idiopathic cholestasis: a condition more common in the Canadian Inuit?

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