A multi-scale nonlinear procedure to analyze the stress in Nb3Sn superconducting accelerator magnets is presented to address one of the most challenging obstacles currently facing the successful development of high-field superconducting magnets—the issue of stress management. The study demonstrates that gaskets (special nonlinear materials) are capable of modeling the complex nonlinear deformation behavior of insulation layers within the Nb3Sn coil block and that Hill materials (orthotropic materials utilizing the Hill yield criterion) are suitable to enable homogenization of the filamentary regions and the resin-impregnated Nb3Sn Rutherford cables. With the whole magnet under preload, cool-down, and Lorentz forces, the nonlinear behavior of the Nb3Sn coil was simulated, in three orthongonal axes, by the combined properties of the gaskets (insulation layers) and Hill materials (resin-impreganted cable). The procedure entailes minimal material assumptions because it incorporated measured stress-strain curves in the analysis. The coil was simulated to a high level of detail consisting of the insulation layers and resin-impregnated cables. The computed compressive azimuthal stresses of the cables were used to assess the stress-induced performance degradation. Through submodeling, the area-weighted average axial strains of the strands were computed and employed to evaluate the strain-induced performance degradation. The overall performance degradation of the Nb3Sn coil was thus obtained, and this information was subsequently used to guide the design of the overall magnet. Besides Nb3Sn magnets, this procedure can also be employed in the design of LTS, HTS, and room temperature magnets or in any composite structures.