Summary report for the expert panel review of the toxicological profile for mercury

Jf, Risher; Ct, De Rosa; De, Jones; He, Murray

doi:10.1177/074823379901500504

Cited by 17 publications

(8 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Methyl mercury is a common food contaminant, especially of fish. [1] High exposures to elemental or inorganic mercury produce acrodynia, with proteinuria, mood and visual changes, and a rash. [2] High prenatal exposure to methyl mercury produces a cerebral palsy-like illness in children; there have been three major outbreaks, two in Japan from contaminated fish,[3, 4] and one in Iraq from consumption of seed wheat preserved with methyl mercury.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Succimer Chelation of Mercury at Background Exposures in Toddlers: A Randomized Trial

Cao

Chen

Jones

et al. 2011

The Journal of Pediatrics

View full text Add to dashboard Cite

Objective To examine whether succimer, a mercaptan compound known to reduce blood lead concentration in children, reduces blood mercury concentration. Study Design We used samples from a randomized clinical trial of succimer chelation for lead-exposed children. We measured mercury in pre-treatment samples from 767 children. We also measured mercury in blood samples drawn 1 week after treatment began (N=768) and in a 20% random sample of the children who received the maximum 3 courses of treatment (N=67). A bootstrap-based isotonic regression method was used to compare the trend over time in the difference between the adjusted mean mercury concentrations in the succimer group and the placebo group. Results The adjusted mean organic mercury concentration in the succimer group relative to the placebo group fell from 99% at baseline to 82% after three courses of treatment (p for trend = 0.048), but this resulted from the prevention of the age-related increase in the succimer group. Conclusion Succimer chelation for low level organic mercury exposure in children has limited efficacy.

show abstract

Section: Introductionmentioning

confidence: 99%

Efficacy of Succimer Chelation of Mercury at Background Exposures in Toddlers: A Randomized Trial

Cao

Chen

Jones

et al. 2011

The Journal of Pediatrics

View full text Add to dashboard Cite

show abstract

“…Mercury is an established environmental pollutant with a variety of serious health effects in humans (Risher et al, 1999). Numerous attempts have been made to identify and characterize useful biomarkers of exposure to mercury, including blood, urine, hair, fingernails and toenails, both as correlates of environmental exposures and also in relation to diseases such as coronary heart disease (e.g., Sinclair et al, 1980;MacIntosh et al, 1997;Guallar et al, 2002;Mortada et al, 2002;Yoshizawa et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Toenail mercury and dietary fish consumption

Rees

Stürup

Chen

et al. 2006

J Expo Sci Environ Epidemiol

View full text Add to dashboard Cite

New England is one of three areas in the United States with the highest annual deposition of mercury, an established environmental pollutant with a variety of health effects. We measured the mercury content in toenails of 27 individuals in New Hampshire who participated as controls in a health study in 1994-95. The mean total toenail mercury concentration was 0.27 mcg/g (median 0.16; SD 0.27; range 0.04-1.15 mcg/g). The best predictor of toenail mercury levels was the mean combined fish and shellfish consumption measured using four simple questions from a validated food frequency questionnaire. Toenail total mercury content was significantly correlated with the mean average weekly consumption of finfish and shellfish (Spearman correlation coefficient 0.48, P ¼ 0.012). Multivariate models confirmed that toenail total mercury concentration was best predicted by total finfish and shellfish consumption. Keywords: mercury, fish consumption, exposure assessment, metals, epidemiology. IntroductionMercury is an established environmental pollutant with a variety of serious health effects in humans (Risher et al., 1999). Numerous attempts have been made to identify and characterize useful biomarkers of exposure to mercury, including blood, urine, hair, fingernails and toenails, both as correlates of environmental exposures and also in relation to diseases such as coronary heart disease (e.g., Sinclair et al., 1980;MacIntosh et al., 1997;Guallar et al., 2002;Mortada et al., 2002;Yoshizawa et al., 2002). Toenail mercury concentrations are reasonably stable indicators of exposure over time (Garland et al., 1993) and toenails have the advantage over hair and fingernails of being less susceptible to external contamination. Toenail mercury content is significantly associated with fish consumption; in fact, knowledge of fish consumption alone can be sufficient to characterize mercury exposure as measured in toenails (Garland et al., 1993;MacIntosh et al., 1997).New England is one of three areas in the United States with the highest annual deposition of mercury (Rice et al., 1997). Since 1994, the New Hampshire Department of Health and Human Services has issued a fish consumption advisory because of mercury contamination (New Hampshire Department of Health and Human Services Bureau of Health Risk Assessment, 2001) and studies of wildlife have demonstrated high mercury levels in eight states in north America (Evers et al., 2003). To our knowledge, no published studies have described biomarkers of mercury exposure in New Hampshire's human population. The aims of this pilot study were to analyze mercury levels in toenails taken from individuals in New Hampshire who participated as controls in a previous health study, and to determine their correlation with three dietary measures of seafood intake. MethodsWe analyzed toenail clippings obtained from control subjects during a case-control study conducted in 1994-95 in New Hampshire, which was reported previously (Karagas et al., 1998;Karagas et al., 2001). The original study investi...

show abstract

“…Mercury exposure can pose a significant threat to human health and its effects on the nervous and urinary systems are well documented 20. Previous studies of workers in fluorescent tube manufacturing, wood processing, chloralkali and thermometer plants have demonstrated slight central nervous system toxicity at mercury vapour concentrations in air as low as 20 μg/m 3 21.…”

Section: Discussionmentioning

confidence: 99%

Occupational exposures and risk of acoustic neuroma

et al. 2010

View full text Add to dashboard Cite

We observed an increased risk of acoustic neuroma associated with occupational exposure to mercury, benzene and textile dust. Men working as truck and conveyor operators <10 years before the reference year had the highest increased risk of acoustic neuroma, but it is unclear what in those occupations might contribute to disease development. Our study also suggested an association between acoustic neuroma and being a class teacher or policeman. However, these findings should be further investigated to exclude the possibility of detection bias.

show abstract

Summary report for the expert panel review of the toxicological profile for mercury

Cited by 17 publications

References 15 publications

Efficacy of Succimer Chelation of Mercury at Background Exposures in Toddlers: A Randomized Trial

Efficacy of Succimer Chelation of Mercury at Background Exposures in Toddlers: A Randomized Trial

Toenail mercury and dietary fish consumption

Occupational exposures and risk of acoustic neuroma

Contact Info

Product

Resources

About