Summer squash

Díaz, María Teresa Blanco; Font, Rafael; Gómez, Pedro Sánchez; Río-Celestino, Mercedes Del

doi:10.1016/b978-0-12-812780-3.00014-3

Cited by 3 publications

(3 citation statements)

References 48 publications

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“…As a part of the plants' defense mechanism, they possess the antimicrobial, antiviral, and anti-inflammatory properties. Their anti-tumour effects were proven in cervical, lung, colon, bladder and prostate cancer, as well as in hepatoblastoma-derived cell lines [132][133][134][135]. In the study conducted by Ahmed and Halaweish, Cucs exhibited cytotoxicity on the SK-MEL-28 and A375 cell line, with the lowest IC 50 value of ca.…”

Section: Other Triterpenoidsmentioning

confidence: 99%

Plant-Derived Terpenoids: A Promising Tool in the Fight against Melanoma

Kłos

Chlubek

2022

Cancers

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Melanoma is responsible for the highest number of skin cancer-caused deaths worldwide. Despite the numerous melanoma-treating options, the fight against it remains challenging, mainly due to its great heterogeneity and plasticity, as well as the high toxicity of standard drugs. Plant-derived terpenoids are a group of plant defense molecules that have been proven effective in killing many different types of cancer cells, both in in vitro experiments and in vivo models. In this review, we focus on recent results in the search for plant terpenoids with anti-melanoma activity. We also report on the synergistic action of combining terpenoids with other plant-derived substances, MAP kinase inhibitors, or radiation. Additionally, we present examples of terpenoid-loaded nanoparticle carriers as anti-melanoma agents that have increased permeation through the cancer tissue.

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Section: Other Triterpenoidsmentioning

confidence: 99%

Plant-Derived Terpenoids: A Promising Tool in the Fight against Melanoma

Kłos

Chlubek

2022

Cancers

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“…Various natural products have been reviewed in terms of their potential to fight the disease, taking into consideration the specific targets [5]. Cucurbitacins, tetracyclic triterpenoids occur in regularly consumed vegetables like cucumber, gourds, squash, and pumpkins as secondary metabolites and act in the plant's defense mechanisms [6]. The molecular structure of Cucurbitacin I is shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

nCoV-19 therapeutics using cucurbitacin I structural derivatives: an in silico approach

Shrestha,

Marasini,

Subin

2024

Futur J Pharm Sci

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Background Cucurbitacins are present in some common vegetables as secondary metabolites and are used by the plants against harmful microbes. Exploration of this capability of natural product based substances against wide variety of microbes seems relevant due to the ease of availability of the resources and safety. In this regard, considering the current pandemic, the antiviral properties of these molecules with a subset of Cucurbitacin I structural derivatives have been screened. The inhibition potential of the phytochemicals was assessed by the stability of the protein–ligand complex formed with the nucleocapsid protein (PDB ID: 7CDZ) of SARS-CoV-2 by computational methods. The proposition of an alternate antiviral candidate that is cost-effective and efficient relative to existing formulations is the main objective of this work. Results Server-based molecular docking experiments revealed CBN19 (PubChem CID: 125125068) as a hit candidate among 101 test compounds, a reference molecule (K31), and 5 FDA-approved drugs in terms of binding affinities sorted out based on total energies. The molecular dynamics simulations (MDS) showed moderate stability of the protein-CBN19 complex as implied by various geometrical parameters RMSD, Rg, RMSF, SASA and hydrogen bond count. The ligand RMSD of 3.0 ± 0.5 Å, RMSF of Cα of protein with less than 5 Å, and smooth nature of SASA and Rg curves were calculated for the adduct. The binding free energy (− 47.19 ± 6.24 kcal/mol) extracted from the MDS trajectory using the MMGBSA method indicated spontaneity of the reaction between CBN19 and the protein. The multiple ADMET studies of the phytochemicals predicted some drug-like properties with minimal toxicity that mandate experimental verification. Conclusions Based on all the preliminary in silico results, Cucurbitacin, CBN19 could be proposed as a potential inhibitor of nucleocapsid protein theoretically capable of curing the disease. The proposed molecule is recommended for further in vitro and in vivo trials in the quest to develop effective and alternate therapeutics from plant-based resources against COVID-19.

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“…These compounds can be found in many plants from the genera Bryonia, Cucurbita, Cucumis, Echinocystis, Luffa, Citrullus and Lagenaria, conferring a bitter taste in cucumber [14,15]. Several recent preclinical studies have demonstrated that this group of phytochemicals can exert antitumor activities in a variety of experimental models of different malignancies, including lung cancer [16], gastric cancer [17], colorectal cancer [18], liver cancer [19], pancreatic cancer [20], ovarian cancer [21], cervical cancer [22] and melanoma [23]. Such anticancer effects are achieved via interaction of cucurbitacins with multiple molecular targets and intervening in diverse cellular signaling cascades, suggesting that a high potential of this compound should be developed as a therapeutic tool.…”

Section: Introductionmentioning

confidence: 99%

Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends

et al. 2022

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Cucurbitacins constitute a group of cucumber-derived dietary lipids, highly oxidized tetracyclic triterpenoids, with potential medical uses. These compounds are known to interact with a variety of recognized cellular targets to impede the growth of cancer cells. Accumulating evidence has suggested that inhibition of tumor cell growth via induction of apoptosis, cell-cycle arrest, anti-metastasis and anti-angiogenesis are major promising chemo-preventive actions of cucurbitacins. Cucurbitacins may be a potential choice for investigations of synergism with other drugs to reverse cancer cells’ treatment resistance. The detailed molecular mechanisms underlying these effects include interactions between cucurbitacins and numerous cellular targets (Bcl-2/Bax, caspases, STAT3, cyclins, NF-κB, COX-2, MMP-9, VEGF/R, etc.) as well as control of a variety of intracellular signal transduction pathways. The current study is focused on the efforts undertaken to find possible molecular targets for cucurbitacins in suppressing diverse malignant processes. The review is distinctive since it presents all potential molecular targets of cucurbitacins in cancer on one common podium.

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Summer squash

Cited by 3 publications

References 48 publications

Plant-Derived Terpenoids: A Promising Tool in the Fight against Melanoma

Plant-Derived Terpenoids: A Promising Tool in the Fight against Melanoma

nCoV-19 therapeutics using cucurbitacin I structural derivatives: an in silico approach

Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends

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