2024
DOI: 10.1101/2024.02.27.582283
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SUMO-mediated regulation of a H3K4me3 reader controls germline development inC. elegans

Cátia A. Carvalho,
Ulrike Bening Abu-Shach,
Asha Raju
et al.

Abstract: ULP-2 is a conserved SUMO protease required for embryonic development inC. elegans. Here we revealed that ULP-2 controls germline development by regulating the PHD-SET domain protein, SET-26. Specifically, theulp-2mutant hermaphrodites exhibit increased sterility and progressive elevation in global protein sumoylation. In the progeny of homozygous animals, meiosis is arrested at the diplotene stage and the cells in the proximal germline acquire a somatic fate. Germline RNAseq analysis revealed the downregulati… Show more

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