Sumo-regulatory SENP2 controls the homeostatic squamous mitosis-differentiation checkpoint
Jesús Galán-Vidal,
Lorena García-Gaipo,
Rut Molinuevo
et al.
Abstract:Squamous or epidermoid cancer arises in stratified epithelia but also is frequent in the non-epidermoid epithelium of the lung by unclear mechanisms. A poorly studied mitotic checkpoint drives epithelial cells bearing irreparable genetic damage into epidermoid differentiation. We performed an RNA-sequencing gene search to target unknown regulators of this response and selected the SUMO regulatory protein SENP2. Alterations of SENP2 expression have been associated with some types of cancer. We found the protein… Show more
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