SUMOylation of spastin promotes the internalization of GluA1 and regulates dendritic spine morphology by targeting microtubule dynamics

Ji, Zhisheng; Liu, Qiuling; Zhang, Jifeng; Yang, Ye; Li, Jiong; Zhang, Guowei; Tan, Minghui; Lin, Hongsheng; Guo, Guoqing

doi:10.1016/j.nbd.2020.105133

Cited by 22 publications

(35 citation statements)

References 76 publications

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“…As such, spastin potentially regulates dendritic spine morphology by altering MT-dependent transport. However, another study suggested that overexpression of spastin leads to an increase in the proportion of immature dendritic spines and leads to a decrease in GluA1 membrane expression (26). That study also indicated that GluA1 trafficking is closely related to spastin-mediated endosomal trafficking.…”

Section: Neurogenesismentioning

confidence: 93%

“…However, how M87 works and coordinates with M1 remains largely elusive. Recent studies further highlight the important roles of spastin during neurogenesis (21), axonal development (22)(23)(24), synapse formation and spine maturation (25)(26)(27). Furthermore, an innovative severing model has been proposed, which provides novel insight regarding microtubule (MT)-related activities, thus reasonably elucidating the mechanisms of the roles of spastin in physiological and pathological conditions (28,29).…”

Section: Molecular and Cellular Mechanisms Of Spastin In Neural Development And Disease (Review)mentioning

confidence: 99%

“…For instance, numerous transcription factors (NRF1 and SOX11) and microRNAs (miRs), including miR-30, -33a, -96 and -182, are able to regulate the expression levels of spastin (79)(80)(81). At the posttranscriptional level, spastin may be phosphorylated at S268 and recruited to the midbody (62); SUMOylation of spastin at K427 may alter the severing ability of spastin (26); ubiquitination of spastin at K554 mediates degradation (82). In addition, the consolidation of protein on MT (Tau, collapsin response mediator protein 5) also regulates the severing activity of spastin (83,84).…”

Section: Regulation Of Spastin's Stability and Activitymentioning

confidence: 99%

“…In the last decade, research on spastin has primarily focused on axonal behavioral mechanisms. It is worth noting that M87 spastin is distributed in the entire cell compartment, including dendrites and dendritic spines (26,100). How M87 spastin affects dendrite behaviors remains largely elusive.…”

Section: Neurogenesismentioning

confidence: 99%

“…Recent studies further indicated that spastin is closely related to learning and memory. Furthermore, it participates in the formation and maturation of dendritic spines and regulates the transport of the α-amino-3-hydroxy-5methyl-4-isoxazolepropionic acid receptor (AMPAR) subunit GluA1 (26) and GluA2 (25). Lopes et al (25) established a spastin-knockout mouse model and determined that the formation and maturation of dendritic spines were inhibited upon spastin depletion and that KIF5-mediated GluA2 transport was also blocked upon spastin depletion.…”

Section: Neurogenesismentioning

confidence: 99%

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Molecular and cellular mechanisms of spastin in neural development and disease (Review)

Liu

Zhang

et al. 2021

Int J Mol Med

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Spastin is a microtubule (MT)-severing enzyme identified from mutations of hereditary spastic paraplegia in 1999 and extensive studies indicate its vital role in various cellular activities. In the past two decades, efforts have been made to understand the underlying molecular mechanisms of how spastin is linked to neural development and disease. Recent studies on spastin have unraveled the mechanistic processes of its MT-severing activity and revealed that spastin acts as an MT amplifier to mediate its remodeling, thus providing valuable insight into the molecular roles of spastin under physiological conditions. In addition, recent research has revealed multiple novel molecular mechanisms of spastin in cellular biological pathways, including endoplasmic reticulum shaping, calcium trafficking, fatty acid trafficking, as well as endosomal fission and trafficking. These processes are closely involved in axonal and dendritic development and maintenance. The current review presents recent biological advances regarding the molecular mechanisms of spastin at the cellular level and provides insight into how it affects neural development and disease.

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Section: Neurogenesismentioning

confidence: 93%

Section: Molecular and Cellular Mechanisms Of Spastin In Neural Development And Disease (Review)mentioning

confidence: 99%

Section: Regulation Of Spastin's Stability and Activitymentioning

confidence: 99%

Section: Neurogenesismentioning

confidence: 99%

Section: Neurogenesismentioning

confidence: 99%

See 3 more Smart Citations

Molecular and cellular mechanisms of spastin in neural development and disease (Review)

Liu

Zhang

et al. 2021

Int J Mol Med

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The fidgetin family: Shaking things up among the microtubule‐severing enzymes

Smart,

Sharp

2023

Cytoskeleton

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The microtubule cytoskeleton is required for several crucial cellular processes, including chromosome segregation, cell polarity and orientation, and intracellular transport. These functions rely on microtubule stability and dynamics, which are regulated by microtubule‐binding proteins (MTBPs). One such type of regulator is the microtubule‐severing enzymes (MSEs), which are ATPases Associated with Diverse Cellular Activities (AAA+ ATPases). The most recently identified family are the fidgetins, which contain three members: fidgetin, fidgetin‐like 1 (FL1), and fidgetin‐like 2 (FL2). Of the three known MSE families, the fidgetins have the most diverse range of functions in the cell, spanning mitosis/meiosis, development, cell migration, DNA repair, and neuronal function. Furthermore, they offer intriguing novel therapeutic targets for cancer, cardiovascular disease, and wound healing. In the two decades since their first report, there has been great progress in our understanding of the fidgetins; however, there is still much left unknown about this unusual family. This review aims to consolidate the present body of knowledge of the fidgetin family of MSEs and to inspire deeper exploration into the fidgetins and the MSEs as a whole.

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Effects of DeSUMOylated Spastin on AMPA Receptor Surface Delivery and Synaptic Function Are Enhanced by Phosphorylating at Ser210

Zhang,

Zhang

et al. 2024

Mol Neurobiol

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SUMOylation of spastin promotes the internalization of GluA1 and regulates dendritic spine morphology by targeting microtubule dynamics

Cited by 22 publications

References 76 publications

Molecular and cellular mechanisms of spastin in neural development and disease (Review)

Molecular and cellular mechanisms of spastin in neural development and disease (Review)

The fidgetin family: Shaking things up among the microtubule‐severing enzymes

Effects of DeSUMOylated Spastin on AMPA Receptor Surface Delivery and Synaptic Function Are Enhanced by Phosphorylating at Ser210

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