SUMOylation of synaptic and synapse‐associated proteins: An update

Henley, Jeremy M.; Seager, Richard; Nakamura, Yasuko; Talandyte, Karolina; Nair, Jithin; Wilkinson, Kevin A.

doi:10.1111/jnc.15103

Cited by 27 publications

(38 citation statements)

References 140 publications

(168 reference statements)

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“…The SUMOylation machinery has been described in both hippocampal and cortical neurons in several reports. 6 , 13 The data so far in primary hippocampal neurons are in line with previous SIM analysis, that showed partial co-localization between members of the SUMO machinery (such as SUMO1, SUMO2/3, Ubc9 and SENPs proteins) and synaptic markers. 26 , 27 This all supports a role of the whole SUMOylation machinery in the formation of spatial memory and long-term potentiation (LTP).…”

Section: Discussionsupporting

confidence: 88%

Super-resolution study of PIAS SUMO E3-ligases in hippocampal and cortical neurons

et al. 2021

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The SUMOylation machinery is a regulator of neuronal activity and synaptic plasticity. It is composed of SUMO isoforms and specialized enzymes named E1, E2 and E3 SUMO ligases. Recent studies have highlighted how SUMO isoforms and E2 enzymes localize with synaptic markers to support previous functional studies but less information is available on E3 ligases. PIAS proteins - belonging to the protein inhibitor of activated STAT (PIAS) SUMO E3-ligase family - are the best-characterized SUMO E3-ligases and have been linked to the formation of spatial memory in rodents. Whether however they exert their function co-localizing with synaptic markers is still unclear. In this study, we applied for the first time structured illumination microscopy (SIM) to PIAS ligases to investigate the co-localization of PIAS1 and PIAS3 with synaptic markers in hippocampal and cortical murine neurons. The results indicate partial co-localization of PIAS1 and PIAS3 with synaptic markers in hippocampal neurons and much rarer occurrence in cortical neurons. This is in line with previous super-resolution reports describing the co-localization with synaptic markers of other components of the SUMOylation machinery.

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Section: Discussionsupporting

confidence: 88%

Super-resolution study of PIAS SUMO E3-ligases in hippocampal and cortical neurons

et al. 2021

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“…SMO-1 is expressed in all animal tissues and mainly localizes to the nucleus 66 . Accordingly, the most studied functions of SUMO are nucleus-associated 14 , 67 , 68 ; however, its role outside of the nucleus is emerging 69 , with a focus on the nervous system. Indeed, we find that tightly controlled expression level of smo-1 is a prerequisite for normal lifespan (Fig.…”

Section: Discussionmentioning

confidence: 99%

SUMO promotes longevity and maintains mitochondrial homeostasis during ageing in Caenorhabditis elegans

Princz

Pelisch

Tavernarakis

2020

Sci Rep

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The insulin/IGF signalling pathway impacts lifespan across distant taxa, by controlling the activity of nodal transcription factors. In the nematode Caenorhabditis elegans, the transcription regulators DAF-16/FOXO and SKN-1/Nrf function to promote longevity under conditions of low insulin/IGF signalling and stress. The activity and subcellular localization of both DAF-16 and SKN-1 is further modulated by specific posttranslational modifications, such as phosphorylation and ubiquitination. Here, we show that ageing elicits a marked increase of SUMO levels in C. elegans. In turn, SUMO fine-tunes DAF-16 and SKN-1 activity in specific C. elegans somatic tissues, to enhance stress resistance. SUMOylation of DAF-16 modulates mitochondrial homeostasis by interfering with mitochondrial dynamics and mitophagy. Our findings reveal that SUMO is an important determinant of lifespan, and provide novel insight, relevant to the complexity of the signalling mechanisms that influence gene expression to govern organismal survival in metazoans.

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“…Like UB, SUMOylation has similar conjugation pathways but the process is carried out by SUMO-specific enzymes [91,95]. In S. cerevisiae, numerous HR proteins including MRE11 are SUMOylated upon DNA damage, parallel to other checkpoint-signaling cascades, thus accelerating DSB repair.…”

Section: Ubiquitination and Ubiquitin-like Modification Of Mre11mentioning

confidence: 99%

Post-Translational Modification of MRE11: Its Implication in DDR and Diseases

Zhang

Jiang

et al. 2021

Genes

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Maintaining genomic stability is vital for cells as well as individual organisms. The meiotic recombination-related gene MRE11 (meiotic recombination 11) is essential for preserving genomic stability through its important roles in the resection of broken DNA ends, DNA damage response (DDR), DNA double-strand breaks (DSBs) repair, and telomere maintenance. The post-translational modifications (PTMs), such as phosphorylation, ubiquitination, and methylation, regulate directly the function of MRE11 and endow MRE11 with capabilities to respond to cellular processes in promptly, precisely, and with more diversified manners. Here in this paper, we focus primarily on the PTMs of MRE11 and their roles in DNA response and repair, maintenance of genomic stability, as well as their association with diseases such as cancer.

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SUMOylation of synaptic and synapse‐associated proteins: An update

Cited by 27 publications

References 140 publications

Super-resolution study of PIAS SUMO E3-ligases in hippocampal and cortical neurons

Super-resolution study of PIAS SUMO E3-ligases in hippocampal and cortical neurons

SUMO promotes longevity and maintains mitochondrial homeostasis during ageing in Caenorhabditis elegans

Post-Translational Modification of MRE11: Its Implication in DDR and Diseases

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