2022
DOI: 10.3389/fimmu.2022.807097
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SUMOylation of Translationally Regulated Tumor Protein Modulates Its Immune Function

Abstract: Translationally controlled tumor protein (TCTP) is a highly conserved protein possessing numerous biological functions and molecular interactions, ranging from cell growth to immune responses. However, the molecular mechanism by which TCTP regulates immune function is largely unknown. Here, we found that knockdown of Bombyx mori translationally controlled tumor protein (BmTCTP) led to the increased susceptibility of silkworm cells to virus infection, whereas overexpression of BmTCTP significantly decreased the… Show more

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Cited by 2 publications
(2 citation statements)
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“…Posttranslational modifications have been extensively reported to be involved in regulating BmNPV‐silkworm interactions; these include phosphorylation (Liu et al, 2023; Yan et al, 2019), acetylation (Gao et al, 2021; Mao et al, 2021; Obeng et al, 2021), ubiquitination (Feng et al, 2018), SUMOylation (Lu et al, 2022), and NEDDylation (Shen et al, 2022). UFMylation plays important roles in a variety of physiological and pathological processes in vertebrates, such as embryonic development, protein homeostasis, immunity, and cancer (Martucciello et al, 2020).…”
Section: Discussionmentioning
confidence: 99%
“…Posttranslational modifications have been extensively reported to be involved in regulating BmNPV‐silkworm interactions; these include phosphorylation (Liu et al, 2023; Yan et al, 2019), acetylation (Gao et al, 2021; Mao et al, 2021; Obeng et al, 2021), ubiquitination (Feng et al, 2018), SUMOylation (Lu et al, 2022), and NEDDylation (Shen et al, 2022). UFMylation plays important roles in a variety of physiological and pathological processes in vertebrates, such as embryonic development, protein homeostasis, immunity, and cancer (Martucciello et al, 2020).…”
Section: Discussionmentioning
confidence: 99%
“…Subsequently, an equal amount of the cDNA was subjected for qRT-PCR assay using the SYBR Premix Ex TaqTM II kit (TaKaRa & Clontech, Dalian, China) on the Applied Biosystems 7500 Fast Real-Time PCR System (Applied Biosystems, Foster City, CA, USA). Eukaryotic translation initiation factor 4A (eIF-4a) was used as the internal control [ 37 ]. All experiments were independently performed with three biological replicates; the relative mRNA expression levels were calculated using the 2 −ΔΔCT method.…”
Section: Methodsmentioning
confidence: 99%