Sun-114 Barrriers to Pre-Emptive Kidney Transplant in New Zealand Children

Abstract

seroconverters and non-seroconverters (coefficient-0.38, CI-1.02-0.27, p=0.256). A lower proportion of patients with a rejection episode prior to vaccination seroconverted relative to those without prior rejection (22% vs 39%, p=0.029), however this association was not significant on multivariable analysis OR 0.51, 95%CI 0.23-1.14, p=0.10. Serious infection prior to vaccination was not associated with seroconversion (OR 1.28, 95%CI 0.47-3.51, p=0.63). Conclusions: Despite a tantalizing logic we were unable to detect a significant association between vaccine response and the immunologic events of rejection or infection post-vaccination. The univariable association of reduced seroconversion with prior rejection may reflect an increased immunosuppressive load and reduced eGFR in such patients as the association lost significance after adjustment for these factors. It will be of interest to examine whether seroresponses to other vaccine types, such as polysaccharide vaccines, are more valuable in predicting immune events.