SUN-140 Cinacalcet Use in Pediatric Chronic Kidney Disease-a survey study

Abstract

Methods: This cross section study included 100 females working in four faculties (medicine, dentistry, pharmacy and veterinary). They were interviewed by well-trained medical students via through history taking suggestive of renal and urinary tract diseases as well as history of hypertension, diabetes, ischemic heart disease (IHD), heart failure and peripheral arterial diseases. Clinical examination included measurement of weight, height in order to calculate body mass index (BMI) and blood pressure. Urine analysis was performed using dipstick. The study population were classified according to SCORED into two groups, risky (score >4) and non-risky (score <4). Results: The mean age of the recruited females was 40.5AE9.9years (range18-60 years). Mean BMI was 32.5AE6.3 kg/m 2 . Prevalence of diabetes, hypertension, IHD, stroke, heart failure and peripheral arterial disease were 13%, 33%, 17%, 4%, 2% and 2% respectively. Asymptomatic urine abnormalities in the form of pyuria (22%), hematuria (18%), proteinuria (9%) and glycosuria (3%) were encountered. Twenty-six percent of the included females had score of >4 and hence had 1in 5 chance of having CKD. Females with risk of developing kidney disease were more frequently diabetics with higher BMI (32.9AE6.5 kg/m 2 in risky group vs 31.6AE4.7 kg/m 2 in non-risky group); however, the difference was statstically insignificant. Hypertension was significantly higher in the risky group (42.4% vs 19.5%, p¼0.01). SCORED risk score $4 was observed in 40% of women aged > 50 years in 23.1% of those aged <50 years. Diabetes, hypertension and proteinuria were significantly more frequently observed among women aged 50 years or more (22.7%, 54.5% and 10% respectively) vs (10.3%, 26% and 4.5% respectively) in group aged less than 50 years. While the prevalence of presence of pyuria was comparable in the two age groups (22.7% in women age $ 50 vs 21.8% in women < 50 years). Conclusions: Risk of developing CKD is not uncommon in women. Asymptomatic hypertension and urinary tract infection are the most prevalent risk factors for CKD among females and should be early detected allowing early interventions to prevent the development of CKD.