SUN-418 Patterns of Thyroid Disease in Basrah, Iraq. Retrospective Study

Mansour, Abbas Ali; Alhamza, Ali Hussain Ali; Almomin, Ammar Mohammed Saeed Abdullah; Zaboon, Ibrahim Abbood; Alibrahim, Nassar Taha Yaseen; Hussein, Rudha Naser; Kadhim, Muayad; Mohammed, Adel Gassab; Al-Waeli, Dheyaa Kadhim; Nwayyir, Hussein Ali; Alidrisi, Haider Ayad; Hussein, Ibrahim Hani; Odhaib, Samih A; Altemimi, Mahmood Thamer; Imran, Husam Jihad

doi:10.1210/jendso/bvaa046.772

Cited by 8 publications

(12 citation statements)

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“…Based on the study's findings; hypothyroidism was more frequent in women than in men (85% versus 15%). This finding is similar to the results of numerous previous studies both in Iraq and worldwide (4,5,22,23) . In a crosssectional study in Baghdad, women with hypothyroidism constituted 77.6% of the studied sample (4) .…”

Section: Discussionsupporting

confidence: 93%

“…These symptoms can be reversed via the standard therapy with levothyroxine; however, some patients may still have persistent symptoms regardless of normalizing thyroid hormones levels (2,3) . In Iraq, the prevalence of hypothyroidism has been studied in different cities (4)(5)(6)(7) where it was found to be 3.2% and 12.5% in Baghdad and Basrah; respectively (4,5) .…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Anxiety and Depression among a Sample of Hypothyroidism-Treated Iraqi Patients

Rasheed,

Al-Metwali,

Al Shamaa

2023

IJPS

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Background: Hypothyroidism is the most prevalent thyroid disorders worldwide. Hypothyroidism manifestations are wide spectrum, affecting various systems in human body including the nervous system. Hypothyroidism can cause neuropsychiatric symptoms such as anxiety, depression and diminishing in attention, memory and executive function. Aim: to investigate the level of anxiety and depression in patients with hypothyroidism receiving levothyroxine treatment. Method: a cross-sectional study was conducted at Baghdad Center for Nuclear Medicine and Radiation Therapy from March to June 2022. The study population included patients of both genders, aged 18-65 years, diagnosed with hypothyroidism, were receiving levothyroxine treatment and have achieved euthyroid state for at least 2 months prior to their enrolment in the study. Based on levothyroxine dose, the enrolled patients were divided into two groups: low dose group < 1.7 µg/kg/day and high dose group ≥ 1.7 µg/kg. Hospital Anxiety and Depression Scale (HADS) was used for the evaluation of anxiety and depression. Result: The mean age of the participants was 40.35 ± 9.5 years with mean body mass index of 30.61 ± 5.72 kg/m2. The mean scores of anxiety and depression for the total sample are 8.72 ±3.46 and 7.80 ±2.83; respectively, there was statistically non-significant difference for anxiety and depression scores between the low dose group and the high dose group. Conclusion: the presence of anxiety and depression symptoms although the patients were in euthyroid state. However, socio-demographic and clinical characteristics did not significantly influence the scores of anxiety and depression.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Evaluation of Anxiety and Depression among a Sample of Hypothyroidism-Treated Iraqi Patients

Rasheed,

Al-Metwali,

Al Shamaa

2023

IJPS

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“…Patients with rheumatoid arthritis, untreated adrenal insufficiency, and Class II or III obesity were excluded as these may affect TSH levels. The Cochran formula [n = Zα 2 pq/d 2 ] was used to calculate the minimum sample size, n 18 ; where Zα is the standard deviation of the normal distribution, given as 1.96 at a significance level of 0.05; p is the percentage to be assessed in the population, taken as the percentage of subclinical hypothyroidism (15 per cent) [19][20][21] ; q=1-p; d represents the acceptable error margin, which is set at 5 per cent. n has been calculated to equal 196.…”

Section: Methodsmentioning

confidence: 99%

Short-term outcomes among patients with subclinical hypothyroidism undergoing primary percutaneous coronary intervention

al-Gburi

al-Obaidi

Abdullah

2023

gmj

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Objectives: This study aimed to examine possible associations between previously undiagnosed subclinical hypothyroidism and short-term outcomes and mortality in a sample of Iraqi patients undergoing primary percutaneous coro-nary intervention for ST-segment elevation myocardial infarction.Design: This is a prospective observational cohort study.Setting: The study was conducted in a single tertiary referral centre in Baghdad, Iraq.Participants: Thyroid-stimulating hormone and free T4 levels were measured in 257 patients hospitalised with ST-elevation myocardial infarction who underwent primary percutaneous coronary intervention between January 2020 and March 2022.Main outcome measures: Adverse cardiovascular and renal events during hospitalisation and 30-day mortality were observed.Results: Previously undiagnosed subclinical hypothyroidism was detected in 36/257 (14%) ST-elevation myocardial infarction patients and observed more commonly in females than males. Patients with subclinical hypothyroidism had significantly worse short-term outcomes, including higher rates of suboptimal TIMI Flow (< III) (p =0.014), left ventricular ejection fraction ≤ 40% (p=0.035), Killip class >I (p=0.042), cardiogenic shock (p =0.016), cardiac arrest in the hospital (p= 0.01), and acute kidney injury (p= 0.044). Additionally, 30-day mortality was significantly higher in patients with subclinical hypothyroidism (p= 0.029).Conclusion: Subclinical hypothyroidism previously undiagnosed and untreated had a significant association with adverse short-term outcomes and higher short-term mortality within 30 days compared to euthyroid patients undergoing primary percutaneous coronary intervention. Routine thyroid function testing during these patients' hospitalisation may be warranted.

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“…Women are around 10 times as likely as men to have hypothyroidism [ 2 ]. According to the latest studies based on large data derived from the Faiha Specialized Diabetes, Endocrine and Metabolism Center - FDEMC, the prevalence of hypothyroidism in Iraq was 12.5%, and women are five times more likely to get affected than men [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Triiodothyronine/Thyroxine Ratio as a Marker of Clinical Response to Levothyroxine Replacement in Patients With Hypothyroidism

Hadi,

Alidrisi,

Mansour

2024

Cureus

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Background: Hypothyroidism is one of the most common endocrine disorders with a simple therapy, that is levothyroxine (LT4). A normal thyroid-stimulating hormone (TSH) measurement is used as a marker of optimal replacement. But, many patients still have symptoms. Triiodothyronine (T3), thyroxine (T4), and their ratio may correlate with clinical improvement. The study aims to assess the T3/T4 ratio as a marker of clinical response in patients with hypothyroidism. Method: A cross-sectional study was conducted from June to November 2022 at Faiha Specialized Diabetes, Endocrine, and Metabolism Center, in Basrah, southern Iraq. We included 48 adult patients with primary hypothyroidism on LT4 treatment only and TSH within the target reference range for at least within the last six months. Each patient was subjected to a questionnaire that was designed to capture hypothyroidism-related complaints in the form of a five-point Likert scale. Biochemical assessments were done with the measurement of TSH, T3, and T4. Results: Despite having a normal TSH level, nearly all the patients had persistent and varying severity of clinical complaints of hypothyroidism. Tiredness, hair problems, weight gain, and cold intolerance were the most severely persistent symptoms. Patients with scores of two and more for weight gain, cold intolerance, and skin problems had significantly lower T3/T4 ratios (P = 0.04, 0.002, and 0.02, respectively), while in the remaining clinical symptoms, the T3/T4 ratio did not differ significantly. Conclusion: A low T3/T4 ratio was significantly associated with resistant symptoms of hypothyroidism and may be used as a marker for treatment efficacy with TSH rather than TSH value alone.

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SUN-418 Patterns of Thyroid Disease in Basrah, Iraq. Retrospective Study

Cited by 8 publications

References 0 publications

Evaluation of Anxiety and Depression among a Sample of Hypothyroidism-Treated Iraqi Patients

Evaluation of Anxiety and Depression among a Sample of Hypothyroidism-Treated Iraqi Patients

Short-term outcomes among patients with subclinical hypothyroidism undergoing primary percutaneous coronary intervention

Triiodothyronine/Thyroxine Ratio as a Marker of Clinical Response to Levothyroxine Replacement in Patients With Hypothyroidism

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