Sun Exposure and the Incidence of Melanocytic Nevi in Young Australian Children

Harrison, Simone L.; MacLennan, Robert; Buettner, Petra G.

doi:10.1158/1055-9965.epi-07-2801

Cited by 53 publications

(54 citation statements)

References 37 publications

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“…A relação existente entre a exposição solar e o desenvolvimento de melanomas cutâneos já é conhecida na medicina humana, entretanto a etiologia em cães e gatos ainda permanece incerta (GALLAGHER; LEE, 2006;HARRISON;MACLENNAN;BUETTNER, 2008;PEHARDA et al, 2007;SITUM et al, 2007;WITHROW, 2007). De acordo com a literatura, os melanomas dérmicos têm um curso benigno e representam 9 a 20% dos tumores cutâneos, enquanto que na cavidade oral e dígitos, o melanoma é o neoplasma maligno de maior ocorrência (KOENIG et al, 2001).…”

Section: Discussionunclassified

Frequência de neoplasmas em cães diagnosticados por exame citológico: estudo retrospectivo em um hospital-escola

et al. 2009

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ResumoO exame citológico é um importante método de diagnóstico de neoplasias em animais de companhia e pode ser realizado em diversas situações clínicas. O objetivo do presente estudo foi determinar a prevalência dos neoplasmas diagnosticados pelo exame citológico em cães atendidos na região de Londrina e avaliar aspectos epidemiológicos relacionados à idade, raça, sexo, comportamento e localização anatômica. Foram avaliados 3788 registros, provenientes da rotina do Laboratório de Anatomia Patológica da Universidade Estadual de Londrina, durante o período de janeiro de 1996 a dezembro de 2006. Dentre estes, 1019 registros foram diagnosticados como neoplasmas. Os neoplasmas de células redondas representaram 44% dos diagnósticos, seguidos pelos neoplasmas epiteliais e mesenquimais com 36,7% e 16%, respectivamente. Os neoplasmas indiferenciados totalizaram 3,3% dos diagnósticos citológicos. Em relação ao comportamento biológico, o comportamento maligno foi mais freqüente nos neoplasmas epiteliais do que nos mesenquimais. Dentre os tumores de células redondas, o mastocitoma, o tumor venéreo transmissível e o linfoma foram os mais significantemente representados. Os cães com raça definida foram os mais acometidos e dentre esses, as raças boxer, poodle e pastor alemão foram as de maior prevalência. A média de idade foi de 7,94 ± 3,55 anos. Não foi observada diferença estatística significativa em relação ao sexo. O períneo foi a localização anatômica preferencial nos neoplasmas epiteliais benignos e tumor venéreo transmissível, enquanto que os tumores mesenquimais benignos localizavam-se freqüentemente na região torácica. Neoplasmas epiteliais e mesenquimais malignos, melanoma e histiocitoma localizavam-se principalmente na cabeça. O mastocitoma apresentou-se mais comumentemente no tronco e membros. Já a manifestação clínica mais freqüente observada no linfoma foi a linfoadenomegalia. Palavras chave: Oncologia, citologia, neoplasmas, epidemiologia, cães AbstractCytological examination is considered a very important method to diagnose neoplasms in pets and can be performed in many clinical situations. The aim of this study was to determine the prevalence of neoplasms diagnosed by cytological examination in dogs from the region of Londrina, and to evaluate epidemiological aspects as age, breed, sex predisposition, biological behaviour and anatomical localization. The data were obtained from the Animal Pathology Laboratory of Universidade Estadual de Londrina. 3378 cases of cytological examinations from the routine service of the laboratory were

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Section: Discussionunclassified

Frequência de neoplasmas em cães diagnosticados por exame citológico: estudo retrospectivo em um hospital-escola

et al. 2009

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“…It is furthermore important to consider that different types of skin cancer have a different dependence on UV exposure patterns. Whereas MMs are mainly induced by intermittent UV exposure (such as sunburns) [11,18,20] , SCC induction is highly dependent on cumulative UV exposure. BCC induction depends on cumulative as well as intermittent exposure patterns [11] .…”

Section: Environmental Risk Factor(s)mentioning

confidence: 99%

Skin Cancer: New Markers for Better Prevention

Greinert¹

2009

Pathobiology

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Skin cancer is the most frequent cancer in the white population worldwide. Incidence of basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and malignant melanoma (MM) is still increasing. This trend can be counteracted by means of primary and secondary prevention because the main risk factor for skin cancer – UV-radiation – is known, and, early detected, skin cancer can be cured successfully. For early detection of skin cancer suitable risk (group) markers have to be used to identify persons at risk. In order to increase the sensitivity and specificity of early detection efforts (screening programs) new molecular markers or biomarkers should be used in the future in the field of molecular epidemiology. In this review the skin cancer problem is summarized and the possible use of new biomarkers for skin cancer development, progression, metastasis and prognosis is discussed. The review focuses on results of gene expression profiling using array techniques and the new possibilities for the use of epigenetic biomarkers.

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“…For example, there is a higher incidence of acquired melanocytic naevi in sun-exposed sites [1,2] . The incidence and number of melanocytic naevi are associated with the cumulative sun exposure [3][4][5] . Moreover, the risk of developing squamous cell carcinomas, skin malignant melanomas and actinic keratoses is strongly associated with lifetime sun exposure [6][7][8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

Sun-Induced Changes in Stratum Corneum Function Are Gender and Dose Dependent in a Chinese Population

Liu

Fluhr

Shu-min

et al. 2010

Skin Pharmacol Physiol

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Previous studies have demonstrated that UVB radiation changes the epidermal permeability barrier and stratum corneum (SC) hydration. It is well known that sun exposure causes erythema, sunburn and melanoma. However, whether daily sun exposure alters SC integrity and epidermal permeability barrier function is largely unknown, especially in Chinese subjects. In the present study, we assess the SC integrity, SC hydration and epidermal permeability barrier function following various doses of sun exposure. A total of 258 subjects (124 males and 134 females) aged 18–50 years were enrolled. A multifunctional skin physiology monitor (Courage & Khazaka MPA5) was used to measure SC hydration and transepidermal water loss (TEWL) on the forearms. In males, basal TEWL was higher with higher doses of sun exposure than with lower doses and control, whereas in females, basal TEWL was higher with lower doses of sun exposure than with higher doses and control. In the group with higher doses of sun exposure, TEWL in females was significantly lower than that in males. The barrier recovery was faster in females than in males in both control and lower-dose groups. In both males and females, barrier recovery was delayed with higher doses of sun exposure. In males, sun exposure did not alter SC hydration, while in females SC hydration was lower with lower doses of sun exposure as compared with control and higher doses of sun exposure. These results demonstrated that sun-induced changes in SC function and SC hydration vary with gender and the extent of sun exposure.

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Sun Exposure and the Incidence of Melanocytic Nevi in Young Australian Children

Cited by 53 publications

References 37 publications

Frequência de neoplasmas em cães diagnosticados por exame citológico: estudo retrospectivo em um hospital-escola

Frequência de neoplasmas em cães diagnosticados por exame citológico: estudo retrospectivo em um hospital-escola

Skin Cancer: New Markers for Better Prevention

Sun-Induced Changes in Stratum Corneum Function Are Gender and Dose Dependent in a Chinese Population

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