Sunlight‐Sensitive Plasmonic Nanostructured Composites as Photocatalytic Coating with Antibacterial Properties

Marín-Caba, Laura; Bodelón, Gustavo; Negrín‐Montecelo, Yoel; Correa‐Duarte, Miguel A.

doi:10.1002/adfm.202105807

Cited by 50 publications

(16 citation statements)

References 64 publications

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“…It was found that these AgNP colloids have excellent photocatalytic activity and are capable of producing reactive oxygen species (ROS) under visible light irradiation. In general, ROS have broad-spectrum biocidal effects and also play an important role in the orchestration of the wound healing response, since they act as secondary messengers to immunocytes and nonlymphoid cells, regulating the angiogenesis at the wound site. − …”

Section: Introductionmentioning

confidence: 99%

Nonreleasing AgNP Colloids Composite Hydrogel with Potent Hemostatic, Photodynamic Bactericidal and Wound Healing-Promoting Properties

Huo

et al. 2023

ACS Appl. Mater. Interfaces

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Reactive oxygen species (ROS) produced by noble metallic nanoparticles under visible light is an effective way to combat drug-resistant bacteria colonized on the wound. However, the photocatalytic efficiency of noble metallic nanoparticles is limited by its self-aggregation in water media. Moreover, the fast release of noble metallic ions from nanoparticles might engender cellular toxicity and hazardous environmental issues. Herein, we chose AgNPs, the most common plasmonic noble metallic nanoparticles, as an example, modifying the surface of AgNPs with oleic acid and n-butylamine and imbedded them into calcium alginate (CA) hydrogel that holds tissue adhesion, rapid hemostatic, sunlightsensitive antibacterial and anti-inflammatory abilities, and thus effectively promotes the healing of wounds. Unlike conventional AgNP-based materials, the constrain of colloids and hydrogel networks hinders the leach of Ag + . Nonetheless, the CA/Ag hydrogels exhibit on-demand photodynamic antibacterial efficacy due to the generation of ROS under visible light. In addition, the CA/Ag hydrogel can effectively stop the hemorrhage in a mouse liver bleeding model due to their skin-adaptive flexibility and tissue adhesiveness. The potent sunlight-responsive antibacterial activity of the CA/Ag hydrogel can effectively kill multidrug-resistant bacteria both in vitro (>99.999%) and in vivo (>99.9%), while the diminished Ag + release guarantees its biocompatibility. The CA/Ag hydrogel significantly promotes the wound healing process by the downregulation of proinflammatory cytokines (TNF-α and IL-6) in a rodent full-thickness cutaneous wound model. Overall, the proposed multifunctional CA/Ag nanocomposite hydrogel has excellent prospects as an advanced wound dressing.

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Section: Introductionmentioning

confidence: 99%

Nonreleasing AgNP Colloids Composite Hydrogel with Potent Hemostatic, Photodynamic Bactericidal and Wound Healing-Promoting Properties

Huo

et al. 2023

ACS Appl. Mater. Interfaces

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“…Although studies of sunlighttriggered nanomaterials are limited, with the development of visible photocatalysts, sunlight-enabled antibacterial nanomaterials will attract increasing attention. [60,61]…”

Section:  Photo-mediated Bacterial Killingmentioning

confidence: 99%

Recent advances in targeted antibacterial therapy basing on nanomaterials

2023

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Bacterial infection has become one of the leading causes of death worldwide, particularly in low-income countries. Despite the fact that antibiotics have provided successful management in bacterial infections, the long-term overconsumption and abuse of antibiotics has contributed to the emergence of multidrug resistant bacteria. To address this challenge, nanomaterials with intrinsic antibacterial properties or that serve as drug carriers have been substantially developed as an alternative to fight against bacterial infection. Systematically and deeply understanding the antibacterial mechanisms of nanomaterials is extremely important for designing new therapeutics. Recently, nanomaterials-mediated targeted bacteria depletion in either a passive or active manner is one of the most promising approaches for antibacterial treatment by increasing local concentration around bacterial cells to enhance inhibitory activity and reduce side effects. Passive targeting approach is widely explored by searching nanomaterialbased alternatives to antibiotics, while active targeting strategy relies on biomimetic or biomolecular surface feature that can selectively recognize targeted bacteria. In this review article, we summarize the recent developments in the field of targeted antibacterial therapy based on nanomaterials, which will promote more innovative thinking focusing on the treatment of multidrug-resistant bacteria.

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“…Marín-Caba et al presented a TiO 2 /AuNRs composite for bacteria photoinactivation, aiming to expand the photocatalysis action to the visible and near-infrared ranges. Upon sunlight irradiation, the composites exhibited strong biofilms inactivation and antimicrobial activity (Figure A) . Meanwhile, Wu et al synthesized a Schottky heterojunction photocatalyst (Ag 2 S/Ti 3 C 2 ) to treat bacteria infections after exposure of 808 nm light, and the efficacy was up to 99.99% within 20 min (Figure B) …”

Section: Design Strategies For Improving Photocatalytic Performancementioning

confidence: 99%

Photocatalytic Antimicrobials: Principles, Design Strategies, and Applications

Ran,

Wang

et al. 2023

Chem. Rev.

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Nowadays, the increasing emergence of antibiotic-resistant pathogenic microorganisms requires the search for alternative methods that do not cause drug resistance. Phototherapy strategies (PTs) based on the photoresponsive materials have become a new trend in the inactivation of pathogenic microorganisms due to their spatiotemporal controllability and negligible side effects. Among those phototherapy strategies, photocatalytic antimicrobial therapy (PCAT) has emerged as an effective and promising antimicrobial strategy in recent years. In the process of photocatalytic treatment, photocatalytic materials are excited by different wavelengths of lights to produce reactive oxygen species (ROS) or other toxic species for the killing of various pathogenic microbes, such as bacteria, viruses, fungi, parasites, and algae. Therefore, this review timely summarizes the latest progress in the PCAT field, with emphasis on the development of various photocatalytic antimicrobials (PCAMs), the underlying antimicrobial mechanisms, the design strategies, and the multiple practical antimicrobial applications in local infections therapy, personal protective equipment, water purification, antimicrobial coatings, wound dressings, food safety, antibacterial textiles, and air purification. Meanwhile, we also present the challenges and perspectives of widespread practical implementation of PCAT as antimicrobial therapeutics. We hope that as a result of this review, PCAT will flourish and become an effective weapon against pathogenic microorganisms and antibiotic resistance.

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Sunlight‐Sensitive Plasmonic Nanostructured Composites as Photocatalytic Coating with Antibacterial Properties

Cited by 50 publications

References 64 publications

Nonreleasing AgNP Colloids Composite Hydrogel with Potent Hemostatic, Photodynamic Bactericidal and Wound Healing-Promoting Properties

Nonreleasing AgNP Colloids Composite Hydrogel with Potent Hemostatic, Photodynamic Bactericidal and Wound Healing-Promoting Properties

Recent advances in targeted antibacterial therapy basing on nanomaterials

Photocatalytic Antimicrobials: Principles, Design Strategies, and Applications

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