Sunshine vitamin and thyroid

Nettore, Immacolata Cristina; Albano, Luigi; Ungaro, Paola; Colao, Annamaria; Macchia, Paolo Emidio

doi:10.1007/s11154-017-9406-3

Cited by 50 publications

(39 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There are three essential steps in the metabolism of this vitamin, which are carried out by cytochrome P450 oxidases: 25-hydroxylation, which produces 25(OH)D (calcidiol); 1α-hydroxylation, which generates 1,25(OH) 2 D (calcitriol); and 24-hydroxylation, which inactivates 25(OH)D and 1,25(OH) 2 D (preferentially), preventing the accumulation of toxic levels [4][5][6]; see Figure 2.…”

Section: Metabolism and Functions Of Vitamin Dmentioning

confidence: 99%

“…Additionally, birth month can influence the risk of developing AID, most likely in relation to exposure to ultraviolet radiation [14]. In general, VitD tends to activate the innate immune response and to regulate the adaptative immune response [5,6,14]. VitD appears to have the ability to stimulate the differentiation of monocytes into macrophages and the production of antibacterial substances by these cells, promoting an initial response [9,16], but also helps to avoid excessive innate responses and consequent tissue damage [16].…”

Section: Vitamin D and Immune Modulationmentioning

confidence: 99%

See 1 more Smart Citation

Vitamin D and Autoimmune Thyroid Disease—Cause, Consequence, or a Vicious Cycle?

Vieira¹,

Rodrigues

Paiva³

2020

Nutrients

View full text Add to dashboard Cite

Vitamin D is a steroid hormone traditionally connected to phosphocalcium metabolism. The discovery of pleiotropic expression of its receptor and of the enzymes involved in its metabolism has led to the exploration of the other roles of this vitamin. The influence of vitamin D on autoimmune disease—namely, on autoimmune thyroid disease—has been widely studied. Most of the existing data support a relationship between vitamin D deficiency and a greater tendency for development and/or higher titers of antibodies linked to Hashimoto’s thyroiditis, Graves’ disease, and/or postpartum thyroiditis. However, there have also been some reports contradicting such relationships, thus making it difficult to establish a unanimous conclusion. Even if the existence of an association between vitamin D and autoimmune thyroid disease is assumed, it is still unclear whether it reflects a pathological mechanism, a causal relationship, or a consequence of the autoimmune process. The relationship between vitamin D’s polymorphisms and this group of diseases has also been the subject of study, often with divergent results. This text presents a review of the recent literature on the relationship between vitamin D and autoimmune thyroid disease, providing an analysis of the likely involved mechanisms. Our thesis is that, due to its immunoregulatory role, vitamin D plays a minor role in conjunction with myriad other factors. In some cases, a vicious cycle is generated, thus contributing to the deficiency and aggravating the autoimmune process.

show abstract

Section: Metabolism and Functions Of Vitamin Dmentioning

confidence: 99%

Section: Vitamin D and Immune Modulationmentioning

confidence: 99%

Vitamin D and Autoimmune Thyroid Disease—Cause, Consequence, or a Vicious Cycle?

Vieira¹,

Rodrigues

Paiva³

2020

Nutrients

View full text Add to dashboard Cite

show abstract

“…По данным масштабных эпидемиологических исследований, проводимых во всем мире, выяснилось, что дефицит витамина D у взрослых широко распространен как в странах северных широт, так и в благополучных южных странах вне зависимости от уровня инсоляции [3][4][5]. Например, 60 и 72% постменопаузальных женщин в Канаде и Индонезии соответственно страдают гиповитаминозом D [6,7]. Значительный дефицит кальцидиола (менее 10 нг/мл) очень распространен в странах Южной Азии и на Ближнем Востоке [8,9].…”

unclassified

Osteal and extraosteal effects of vitamin D and its opportunities of medication correction of its deficiency

Салухов¹,

Ковалевская²,

Курбанова³

2018

Med. sov.

View full text Add to dashboard Cite

Общеизвестна решающая роль витамина D в поддержании здоровья опорно-двигательной системы. С учетом высокой распространенности нарушений кальций-фосфорного обмена в данной статье мы рассмотрим некоторые аспекты дисфункции метаболизма костей, вызванные дефицитом витамина D. Кроме того, недавние исследования показали, что внекостные эффекты витамина D так многообразны и значительны, что позволяют трактовать его роль в организме как глобального регулятора гомеостаза организма. В связи с этим в настоящем обзоре мы проанализируем и обобщим плейотропные эффекты витамина D, касающиеся его влияния на самые разные органы и системы организма, а также приведем результаты некоторых исследований, убедительно продемонстрировавших, что оптимальный уровень витамина D в крови оказывает благотворное влияние на здоровье и защищает организм человека от множества болезней цивилизации. Будут рассмотрены подходы по медикаментозной коррекции недостаточности или дефицита витамина D, приведен клинический случай, показывающий трудности диагностики и лечения гиповитаминоза D.

show abstract

“…Part 2 of this issue (September), will feature topics in female fertility, polycystic ovarian syndrome and endometriosis,and the relationship to vitamin D [28,29], followed by immunology related aspects including kidney transplantation, autoimmune endocrine disorders including thyroid and adrenal disease [30][31][32][33]. After an expedition covering extraskeletal aspects of vitamin D, the concluding review focuses on musculoskeletal health [34].…”

mentioning

confidence: 99%

New light on an old vitamin: The role of the sunshine vitamin D in chronic disease

Koch

2017

Rev Endocr Metab Disord

View full text Add to dashboard Cite

As a child, I always enjoyed consuming milk products and more so as I grew and became active in athletics. One of my dynamic trainers, Dieter Roth, was responsible for leading me and my fellow athletes into Bavarian championships. I was fortunate to never have suffered a fracture from excessive running or weight training. Perhaps my daily vitamin D consumption helped in addition to genetics. I became interested in the science of vitamin D after encountering some patients with hypercalcemia [1]. During my tenure at the University of Mississippi, one of my mentees, Dr. M. Ullah, had expressed desire to explore the field of hypertension and I recommended that he review literature on the topic vitamin D and blood pressure regulation, resulting in several publications [2][3][4][5].My interest grew after I met a pregnant black African American woman that presented with nausea/vomiting, hypertension, a serum calcium of 14 mg/dl (elevated), parathyroid hormone (PTH) level of 102 pg/ml (elevated), and 25-hydroxy(OH) vitamin D level of 12 ng/ml. After hydration and a declining serum calcium to 10 mg/dl, she was prescribed oral vitamin D2 50,000 IU weekly and advised to follow-up. She had a history of noncompliance and (interestingly) took the prescribed vitamin D daily instead of weekly after discharge. She did not follow up in the antenatal or endocrine clinic as scheduled until 3 months later when she presented to the emergency room with headaches and elevated blood pressures (150-170 mm Hg systolic and 70-80 mm Hg diastolic). At this time, her serum calcium level was mildly elevated at 10.9 mg/dl, PTH was 49 pg/ml (inappropriately normal for the level of serum calcium) but the 25-OH vitamin D level was now very high (348.9 ng/ml). At 39 weeks of pregnancy, she had an elective Cesarean delivery of a healthy baby without further complications. The infant was monitored closely for 72 h for any signs of tetany, because of the mother's primary hyperparathyroidism which created a high risk for hypocalcemia. The serum calcium of the baby was normal (10.1 mg/dl) at birth and the baby remained completely asymptomatic at the time of discharge from the hospital, suggesting that at least one parathyroid gland of the baby was not suppressed in functionality, secreting PTH [6].To my knowledge, the highest reported 25-OH vitamin D level of Bvitamin D intoxication^due to food products or dietary supplements is 1482 ng/ml (3700 nmol/L). This has been treated with intravenous fluid hydration, administration of glucocorticoids, sodium phosphate, and bis phosphonates, without complications on 2 year follow-up (reviewed in Araki et al., ref. [7]). The second highest reported 25-OH vitamin D level is 1220 ng/ml (3045 nmol/L) and occurred in a 58-year old man with a concomitant serum calcium of 15 mg/dl (3.75 nmol/L). Symptoms included fatigue, excessive thirst, polyuria, and poor cognition. Utilizing liquid chromatography, tandem mass spectroscopy detected exclusively 25OHD3 and no 25OHD2. The man took multiple supplements with one labeled...

show abstract

Sunshine vitamin and thyroid

Cited by 50 publications

References 69 publications

Vitamin D and Autoimmune Thyroid Disease—Cause, Consequence, or a Vicious Cycle?

Vitamin D and Autoimmune Thyroid Disease—Cause, Consequence, or a Vicious Cycle?

Osteal and extraosteal effects of vitamin D and its opportunities of medication correction of its deficiency

New light on an old vitamin: The role of the sunshine vitamin D in chronic disease

Contact Info

Product

Resources

About