¹³C‐phenylalanine breath test correlates with liver fibrosis in postoperative biliary atresia

Abstract

The PBT values correlated well with liver fibrosis in postoperative BA children. Because PBT is a non-invasive approach, results from this method may serve as a useful and reliable index for post-surgical monitoring of children operated on for liver fibrosis.

European guideline on indications, performance and clinical impact of 13C‐breath tests in adult and pediatric patients: An EAGEN, ESNM, and ESPGHAN consensus, supported by EPC

“…Given that, as yet, few studies have been performed involving small groups of children with rare diseases, 178–181 the use of 13 C‐LFBT for clinical purposes cannot be recommended in the pediatric population, so far.…”

“…For instance, the effect of transarterial chemoembolization on liver function has been monitored by 13 C-methacetin test, 174 and several studies suggest that this test could also be used for planning of hepatic resections. [175][176][177] Given that, as yet, few studies have been performed involving small groups of children with rare diseases, [178][179][180][181] the use of 13 As discussed before, potential confounders of test results detailed in general methodology have to be avoided. For 13 C-LFBT that investigate cytochrome P 450 enzymes, drugs with potential influence on cytochrome P 450 metabolism are of particular relevance, [182][183][184] and it may be necessary to perform a test despite ongoing medication.…”

Gut microbes combined with metabolomics reveal the protective effects of Qijia Rougan decoction against CCl4-induced hepatic fibrosis

“…The metabolite 3-(2-Hydroxyphenyl) propionic acid was significantly negatively correlated with HF-related indices and positively correlated with TJPs, and it was involved in phenylalanine metabolism. A study reported that in children with HF after biliary atresia, significantly decreased phenylalanine metabolism is detected by the (13) C-phenylalanine breath test ( Wada et al, 2007 ). The metabolite 5-L-Glutamyl-taurineis, an intermediate in Taurine and hypotaurine metabolism, was significantly and positively correlated with all HF-related indices.…”