2023
DOI: 10.1002/jlcr.4074
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14C‐radiolabeling of a new steroidal antiandrogen with a C‐18 angular methyl extension

Jean‐Yves Sancéau

Abstract: The synthesis of a 14C‐labeled C‐18 functionalized steroid (as referred as EM‐6798) that will serve as a probe for the research of novel antiandrogens has been accomplished. This radioactive steroid was obtained in nine steps by coupling racemic N‐cyclohexyl‐1‐(3′‐hydroxy[U‐14C]phenyl)propylamine with protected 18‐bromomethyl‐3,17‐androstenedione. Incorporation of the radiolabel on the C‐18 side chain was achieved using commercially available 3‐bromo[U‐14C]phenol. Alkylation of N‐cyclohexyl‐1‐(3′‐hydroxy[U‐14C… Show more

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