2017
DOI: 10.1002/nbm.3726
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17O MRS assesses the effect of mild hypothermia on oxygen consumption rate in tumors

Abstract: Although oxygen consumption is a key factor in metabolic phenotyping, its assessment in tumors remains critical, as current technologies generally display poor specificity. The objectives of this study were to explore the feasibility of direct O nuclear magnetic resonance (NMR) spectroscopy to assess oxygen metabolism in tumors and its modulations. To investigate the impact of hypometabolism induction in the murine fibrosarcoma FSAII tumor model, we monitored the oxygen consumption of normothermic (37°C) and h… Show more

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Cited by 8 publications
(9 citation statements)
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“…It will thus be very interesting in the future to assess the impact of ITPP on OCR in vivo. For this purpose, 17 O magnetic resonance spectroscopy ( 17 O‐MRS) would be the most appropriate choice to observe the modulation of tumour OCR by ITPP . Multiple mechanisms may play a determining role at an early stage, and then the others may become predominant at a later stage.…”
Section: Discussionmentioning
confidence: 99%
“…It will thus be very interesting in the future to assess the impact of ITPP on OCR in vivo. For this purpose, 17 O magnetic resonance spectroscopy ( 17 O‐MRS) would be the most appropriate choice to observe the modulation of tumour OCR by ITPP . Multiple mechanisms may play a determining role at an early stage, and then the others may become predominant at a later stage.…”
Section: Discussionmentioning
confidence: 99%
“…To ensure continuous and reproducible delivery of 17 O-enriched oxygen, we designed a simple breathing circuit ( Figure 1 e) consisting of a prefilled gas-tight syringe, similar to the implementation by Neveu et al [ 17 ], but with automatic actuation of the plunger by an Arduino controlled stepper motor. Inhalation parameters (volume and duration) were prescribed using the tactile graphic user interface ( Figure 1 f).…”
Section: Resultsmentioning
confidence: 99%
“…They also reported CBF changes during hypercapnia. Indirect 17 O-MRI can also visualize pathological conditions, such as cerebral ischemia 57,97,100,101 and tumor blood flow/oxygen metabolism 58,102–105 …”
Section: In Vivo Applications Of 17o-labeled Water Mrimentioning
confidence: 99%
“…Indirect 17 O-MRI can also visualize pathological conditions, such as cerebral ischemia 57,97,100,101 and tumor blood flow/oxygen metabolism. 58,[102][103][104][105] The T1rho technique can be used to quantify CBF. Tailor et al 64 reported that CBF could be quantified after intra-arterial injection of 17 O-labeled water (29%) via the external carotid artery in the rat brain.…”
Section: In Vivo Applications Of 17 O-labeled Water Mri Brain Blood Flowmentioning
confidence: 99%