<sup>18</sup>F-FDG Avidity in Lymphoma Readdressed: A Study of 766 Patients

Weiler-Sagie, Michal; Bushelev, Olga; Epelbaum, Ron; Dann, Eldad J.; Haim, Nissim; Avivi, Irit; Ben-Barak, Ayelet; Ben-Arie, Yehudith; Bar‐Shalom, Rachel; Israel, Ora

doi:10.2967/jnumed.109.067892

Cited by 352 publications

(211 citation statements)

References 23 publications

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“…Moreover, long-term cardio-pulmonary complications of mediastinal irradiation could be avoided in a significant proportion of younger patients, more than 50% according to our results [23]. To improve this strategy, positron emission tomography (PET) could be used to optimize the evaluation of residual mediastinal disease in T-LL [24] and refine the decision criteria for irradiation. In the German study, 41 out of 45 patients with T-LL (91%) had mediastinal involvement, and all received radiation therapy at a dose of 24 Gy [8].…”

Section: Discussionmentioning

confidence: 90%

Results of a lymphoblastic leukemia-like chemotherapy program with risk-adapted mediastinal irradiation and stem cell transplantation for adult patients with lymphoblastic lymphoma

et al. 2011

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The therapeutic role of mediastinal radiotherapy and stem cell transplantation (SCT) in lymphoblastic lymphoma (LL) remains controversial. In a risk-oriented design, we adopted a flexible treatment program in which (1) patients with persistent mediastinal abnormality, evaluated by post-induction computed chest tomography, received mediastinal irradiation; and (2) those with persistence of minimal residual disease (MRD), evaluated by MRD analysis of the bone marrow, underwent SCT.Twenty-eight out of 30 patients (T-lineage, n=24; Blineage, n=6) achieved a complete response. Of 21 patients with mediastinal mass, 13 (62%) achieved a complete response after chemotherapy alone, while 6 (28.5%) required additional irradiation. Eleven patients were evaluated for MRD: 6 were negative and 5 positive. On the basis of MRD findings and clinical risk characteristics, 14 patients underwent SCT, 13 received maintenance chemotherapy, and 1 had local radiotherapy. Five patients Sergio Cortelazzo and Renato Bassan contributed equally to the manuscript.Electronic supplementary material The online version of this article

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Section: Discussionmentioning

confidence: 90%

Results of a lymphoblastic leukemia-like chemotherapy program with risk-adapted mediastinal irradiation and stem cell transplantation for adult patients with lymphoblastic lymphoma

et al. 2011

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“…9,10,[13][14][15][16][17][18]38 Positron emission tomography (PET) using (18)F-fluorodeoxyglucose appears to be a good way to study disease extent in NMZL, considering the PET-positivity in the large majority of cases reported so far (92% of 14 cases). 39,40 Serum lactate dehydrogenase (LDH) is elevated in 12-48% of patients, beta 2 (b2)-microglobulin is increased in 29-45%. 9,10,[13][14][15][16][17][18][19] An M-component is present in 6-33% of patients.…”

Section: Clinical and Laboratory Features Of Patients With Nmzlmentioning

confidence: 99%

Recognizing nodal marginal zone lymphoma: recent advances and pitfalls. A systematic review

Brand

Krieken

2013

Haematologica

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The diagnosis of nodal marginal zone lymphoma is one of the remaining problem areas in hematopathology. Because no established positive markers exist for this lymphoma, it is frequently a diagnosis of exclusion, making distinction from other low-grade B-cell lymphomas difficult or even impossible. This systematic review summarizes and discusses the current knowledge on nodal marginal zone lymphoma, including clinical features, epidemiology and etiology, histology, and cytogenetic and molecular features. In particular, recent advances in diagnostics and pathogenesis are discussed. New immunohistochemical markers have become available that could be used as positive markers for nodal marginal zone lymphoma. These markers could be used to ensure more homogeneous study groups in future research. Also, recent gene expression studies and studies describing specific gene mutations have provided clues to the pathogenesis of nodal marginal zone lymphoma, suggesting deregulation of the nuclear factor kappa B pathway. Nevertheless, nodal marginal zone lymphoma remains an enigmatic entity, requiring further study to define its pathogenesis to allow an accurate diagnosis and tailored treatment. However, recent data indicate that it is not related to splenic or extranodal lymphoma, and that it is also not related to lymphoplasmacytic lymphoma. Thus, even though the diagnosis is not always easy, it is clearly a separate entity. ABSTRACT© F e r r a t a S t o r t i F o u n d a t i o n . Epidemiology and etiology NMZL is a rare lymphoma, accounting for 1.5-1.8% of lymphoid neoplasms. 9,10 The incidence of NMZL appears to be increasing, which is most likely due to a 'real' increase, rather than better recognition.11 Most studies report a median age around 60 years with a wide age distribution ranging from adolescence to patients over 90 years old. [9][10][11][12][13][14][15][16][17][18][19][20] Both sexes are affected with approximately equal frequency.Morphologically, NMZL resembles EMZL. EMZL is well known for its association with conditions that provide a chronic stimulation to the immune system, including chronic infections (e.g. Helicobacter pylori infection in gastric EMZL) and autoimmune conditions (e.g. salivary gland EMZL in Sjögren's syndrome). From this, one could hypothesize that NMZL, or a subset of NMZLs, might also be caused by specific chronic inflammatory conditions. Indeed, infections and autoimmune disorders have been reported in association with NMZL, but this evidence remains far from sufficient to establish a definitive role for these stimuli in lymphomagenesis. Recently, we encountered a case of what we had referred to as NMZL lymphoma in an axillary lymph node. However, we detected H. pylori by PCR analysis and a gastric biopsy revealed EMZL. This case implies that without extensive workup, including gastric biopsies, one cannot be sure that a case of NMZL really represents this entity.Hepatitis C virus (HCV) has been reported in a subset of NMZL patients. In an early but small study, monocytoid B-cell lymph...

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“…Many studies have reported the value of 18 F-fluorodeoxyglucose positron emission tomography ( 18 F-FDG PET), a modality for imaging of glucose metabolism in cancer cells, for evaluation of pleural lesions (2,3). Recently, integrated 18 F-FDG PET/ computed tomography fusion imaging ( 18 F-FDG PET/CT) has been shown to be capable of visualizing the anatomical location of hypermetabolic cancer lesions more accurately than 18 F-FDG PET alone (4)(5)(6). 18 F-FDG PET/CT would thus be more informative for diagnosis of pleural diseases than examination with 18 F-FDG PET (7).…”

Section: Introductionmentioning

confidence: 99%

Clinical implications of 18F-fluorodeoxyglucose positron emission tomography/computed tomography at delayed phase for diagnosis and prognosis of malignant pleural mesothelioma

Abe¹

2011

Oncol Rep

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Abstract. Malignant pleural mesothelioma (MPM) has a poor prognosis, and conventional imaging modalities do not reflect the prognosis of MPM. In this study, the clinical significance of 18 F-fluorodeoxyglucose positron emission tomography/ computed tomography fusion imaging ( 18 F-FDG PET/CT) was evaluated for the differential diagnosis, staging and prognosis in MPM patients. Ninety patients who underwent 18 F-FDG PET/CT scanning due to a clinical diagnosis or suspicion of MPM prior to therapy were reviewed. Of 90 patients, 31 were pathologically diagnosed as MPM. Maximum standardized uptake values (SUVmax) were semi-quantitatively obtained from PET/CT 60 min (early phase) and 120 min (delayed phase) after injection of 18 F-FDG, and the clinicopathological correlations with the level of SUVmax obtained from PET/CT were examined. The survival curves of MPM patients were plotted according to the methods of Kaplan-Meier. The prognostic implications of the level of SUVmax were estimated by t-test. PET/CT scan showed intense abnormal FDG uptake (SUVmax >2.0) in the pleural lesions of all 31 MPM patients at delayed phase, while it showed abnormal FDG uptake in 30 (97%) patients at early phase. In all 31 MPM patients, the values of SUVmax at delayed phase were higher than those at the early phase. PET/CT also indicated metastasis in the lymph node in 7 patients (23%) and in the systemic lesions in 8 patients (26%) with MPM. Twenty-three MPM patients with high SUVmax, whose prognosis was apparent, showed significantly poorer prognosis in both early and delayed phase (respectively, p=0.03 and p=0.01, t-test). The results showed that 18 F-FDG PET/CT at delayed phase is very useful for the diagnosis of pleural diseases, and SUVmax on PET/CT in the delayed phase is a more reliable prognostic factor than that in the early phase. High uptake of 18 F-FDG PET/CT may be a predictive factor of prognosis in MPM patients. IntroductionThe most common cause of pleural effusion is nonspecific pneumonia which can be successfully treated with proper antibiotic therapy. However, pleural effusion may persist and require further examinations in some cases in spite of proper therapy. Computed tomography (CT) provides detailed information on morphological changes, but on its own cannot differ entiate between benign and malignant diseases. Also, invasive pro cedures are frequently required for a definitive diagnosis (1). Many studies have reported the value of 18 F-FDG PET/CT would thus be more informative for diagnosis of pleural diseases than examination with 18 F-FDG PET (7). The incidence of malignant pleural mesothelioma (MPM) in many countries including Japan is rising, as predicted (8,9),

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¹⁸F-FDG Avidity in Lymphoma Readdressed: A Study of 766 Patients

Cited by 352 publications

References 23 publications

Results of a lymphoblastic leukemia-like chemotherapy program with risk-adapted mediastinal irradiation and stem cell transplantation for adult patients with lymphoblastic lymphoma

Results of a lymphoblastic leukemia-like chemotherapy program with risk-adapted mediastinal irradiation and stem cell transplantation for adult patients with lymphoblastic lymphoma

Recognizing nodal marginal zone lymphoma: recent advances and pitfalls. A systematic review

Clinical implications of 18F-fluorodeoxyglucose positron emission tomography/computed tomography at delayed phase for diagnosis and prognosis of malignant pleural mesothelioma

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18F-FDG Avidity in Lymphoma Readdressed: A Study of 766 Patients

Cited by 352 publications

References 23 publications

Results of a lymphoblastic leukemia-like chemotherapy program with risk-adapted mediastinal irradiation and stem cell transplantation for adult patients with lymphoblastic lymphoma

Results of a lymphoblastic leukemia-like chemotherapy program with risk-adapted mediastinal irradiation and stem cell transplantation for adult patients with lymphoblastic lymphoma

Recognizing nodal marginal zone lymphoma: recent advances and pitfalls. A systematic review

Clinical implications of 18F-fluorodeoxyglucose positron emission tomography/computed tomography at delayed phase for diagnosis and prognosis of malignant pleural mesothelioma

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¹⁸F-FDG Avidity in Lymphoma Readdressed: A Study of 766 Patients