<sup>18</sup>F-FDG PET/CT of Cervical Carcinoma

Patel, Chirag; Nazir, Sarfraz; Khan, Zubair Ali; Gleeson, Fergus; Bradley, Kevin M.

doi:10.2214/ajr.10.5084

Cited by 42 publications

(21 citation statements)

References 15 publications

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“…PET/CT is the most expensive diagnostic modality, but has a superior sensitivity (93-96%) and specificity (93-95%) compared to CT and MRI [8]. PET/CT may help distinguish tumor recurrence from a post-therapy residual mass or enlarged reactive lymph nodes, a distinction that is difficult with conventional CT or MRI [9].…”

Section: Diagnostic Proceduresmentioning

confidence: 99%

State-of-the-Art Treatment and Novel Agents in Local and Distant Recurrences of Cervical Cancer

Tempfer

Beckmann²

2016

Oncol Res Treat

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Depending on the stage at initial presentation, cervical cancer will recur in 25-61% of women. Typical manifestations of recurrent cervical cancer include the central pelvis and the pelvic side walls as well as retroperitoneal lymph node basins in the pelvis and the para-aortic region, and - more rarely - supraclavicular lymph nodes. There are no typical symptoms of recurrent cervical cancer. Women with suspected recurrence after cervical cancer based on gynecological examination or organ-specific symptoms must undergo imaging studies and - if technically feasible - biopsy with histological verification, especially in cases of distant metastases, in order to rule out a second primary. Radiotherapy-naïve women should be treated with salvage radiochemotherapy with curative intention. For women with previous radiotherapy, surgery in the form of hysterectomy, local resection, or pelvic exenteration is the treatment of choice. Pelvic exenteration can lead to cure in selected patients, but at the price of a high rate of complications and significant morbidity and mortality. If complete surgical resection is not feasible or if the woman is not a candidate for surgery, chemotherapy with palliative intent should be offered. Patients with recurrent disease outside the pelvis are candidates for systemic chemotherapy. Several agents have shown to be active in this situation, either in single-agent or combination regimens. Platinum-containing regimens have a superior efficacy over non-platinum regimens and bevacizumab may be added to chemotherapy.

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Section: Diagnostic Proceduresmentioning

confidence: 99%

State-of-the-Art Treatment and Novel Agents in Local and Distant Recurrences of Cervical Cancer

Tempfer

Beckmann²

2016

Oncol Res Treat

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“…The FDG is taken up readily by rapidly dividing tumor cells thus providing their location in the organ (Moreno-Sánchez et al, 2007). Sophisticated equipments accurately align and combine metabolic and anatomical images of PET/CT that provide fine anatomical and physiological information (Patel et al, 2011). Utilization of FDG-PET is also helpful in grading, treatment, therapy monitoring, and prognosis of cervical cancer (Grigsby, 2008;.…”

Section: Positron Emission Tomography (Pet)mentioning

confidence: 99%

A cornucopia of screening and diagnostic techniques for human papillomavirus associated cervical carcinomas

Ramzan

Ain

Ilyas

et al. 2015

Journal of Virological Methods

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“…FDG-PET has established roles in the initial evaluation of disease extent, monitoring of therapeutic response, and restaging at the time of disease recurrence [20] in large part as a result of the systematic evaluation of this modality by Washington University investigators.…”

Section: Fluorodeoxyglucose-pet Metabolic Imaging In Cervical Cancermentioning

confidence: 99%

The use of modern imaging technologies in radiation therapy of cervical cancer

Blanco

George

Teh³

et al. 2015

J Radiat Oncol

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Over the past century, definitive management of unresectable cervical cancer has evolved and currently employs high-dose radiation treatment with teletherapy and intracavitary brachytherapy (ICBT) components, combined with concurrent chemotherapy. Reflecting high disease prevalence among developing nations, the International Federation of Gynecology and Obstetrics (FIGO) staging of cervical cancer relies on clinical assessment, with limited radiographic studies. However, multiple clinicopathologic analyses describe suboptimal correlation between clinical examination findings and pathologic stage. Over the past two decades, systematic evaluation of volumetric and functional imaging modalities including CT, MRI, and PET-CT has refined our ability to define disease extent and provide posttreatment surveillance. Similarly, traditional ICBT techniques relied on two-dimensional (2D) data for evaluation of target dose coverage and offered limited assessment of exposure to critical structures including the bladder, rectum, and sigmoid colon. During the last several years, investigators at leading European centers have enhanced the capabilities of existing ICBT techniques through dose optimization [high-dose rate (HDR) and pulsed dose rate (PDR)] and by incorporating volumetric imaging methods. Early results are encouraging, from both toxicity and tumor control perspectives. These techniques are currently being adopted in multiple centers. Pertinent aspects are summarized in the body of this report.

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¹⁸F-FDG PET/CT of Cervical Carcinoma

Abstract: There is increasing evidence that FDG PET/CT has a role in the primary evaluation of cervical carcinoma-in particular, for evaluating lymph node status and distant metastatic disease. PET/CT is also helpful to determine prognosis, assess treatment response, and evaluate disease recurrence.

Cited by 42 publications

References 15 publications

State-of-the-Art Treatment and Novel Agents in Local and Distant Recurrences of Cervical Cancer

State-of-the-Art Treatment and Novel Agents in Local and Distant Recurrences of Cervical Cancer

A cornucopia of screening and diagnostic techniques for human papillomavirus associated cervical carcinomas

The use of modern imaging technologies in radiation therapy of cervical cancer

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18F-FDG PET/CT of Cervical Carcinoma

Cited by 42 publications

References 15 publications

State-of-the-Art Treatment and Novel Agents in Local and Distant Recurrences of Cervical Cancer

State-of-the-Art Treatment and Novel Agents in Local and Distant Recurrences of Cervical Cancer

A cornucopia of screening and diagnostic techniques for human papillomavirus associated cervical carcinomas

The use of modern imaging technologies in radiation therapy of cervical cancer

Contact Info

Product

Resources

About

¹⁸F-FDG PET/CT of Cervical Carcinoma