¹⁸F-FDG PET Evaluation of Sinonasal Papilloma

Abstract

Benign sinonasal papilloma may be associated with intense FDG uptake on PET/CT. FDG PET/CT does not appear to reliably differentiate benign from malignant sinonasal papilloma.

Positron emission tomography evaluation of sinonasal inverted papilloma and related conditions: a prospective clinical study

“…The age of occurrence is usually between 40-70 years. [2] Our study results, locations of IP (eight originated from the lateral Ninomiya et al [10] 1.98-4.65 3.49 5 Shojaku et al [2] 4.9-7.3 5.8 3 Lee et al [9] 9 9 1 Cohen et al [3] * 3.5-9 6.4 4 Jeon et al [4] 7.8-8.2 8 2 Present study* 2.5-9.1 5.2 9 ‡ SUVmax: Maximum standardized uptake value; * Those having oncocytic component were not included in order to be compatible with other studies containing only inverted component, because the oncocytic component has high SUVmax values and it also increases mean values. nasal wall and two arose from the maxillary sinus) the mean age (53.5 years) and male/female ratio of 4:1, are consistent with the literature.…”

“…Moreover, it is also useful to recognize the distinctions between IP and SCC in contrast to some other previous studies. [2,3,9] In our study of 27 patients, an SUV max of 6 or higher ruled out the presence of simple benign nasal polyp [95% CI (5.9 to 13.4), specificity 100%] and might be clinically useful.…”

“…Table 2 shows published PET/CT studies on patients with IP without any malignant transformation when this study was carried out. [2][3][4]9,10] Given these data, it is seen that the average SUV max values ranged from 3.49 to 9. The SUV max value was nine in a patient with IP reported by Lee et al [9] and the authors opined that such a high uptake could not be distinguished from maxillary sinus cancer and was likely due to inflammation in the lesion.…”

“…It has been shown that there is a strong correlation between increased tumoral uptake of FDG and the number of live tumor cells. [3] Although there are studies indicating increased uptake of FDG in the coexistence of IP and SCC, [2] limited data are available about FDG uptake in patients with sole IP. [3,4] The primary aim of this study is to determine whether there is a difference in terms of FDG uptake between IP and SCC, which require therapeutic approaches different from each other.…”

Inability of PET/CT to identify a primary sinonasal inverted papilloma with squamous cell carcinoma in a patient with a submandibular lymph node metastasis: A case report

“…Sinonasal IPs account for 0.5-4% of all sinonasal tumours (1), and are associated with malignant transformation or concurrent invasive squamous cell carcinoma (SCC) in ~9% of cases (2)(3)(4). The one, three and five-year survival rates of sinonasal IP are are 80, 71 and 63%, respectively (1).…”