[<sup>18</sup>F]Fluoride recovery via gaseous [<sup>18</sup>F]HF

Mathiessen, Bente; Jensen, Mikael; Zhuravlev, Fedor

doi:10.1002/jlcr.1931

Cited by 12 publications

(7 citation statements)

References 12 publications

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“…We have recently reported that phosphazenium hydrofluoride [ 18 F]P 2 Et ·HF obtained by the reaction of P 2 Et (Scheme 1) with [ 18 F]HF [15] is an efficient radiofluorination reagent (Scheme 2A) [16].…”

Section: Resultsmentioning

confidence: 99%

Automated Solid-Phase Radiofluorination Using Polymer-Supported Phosphazenes

Mathiessen

Zhuravlev

2013

Molecules

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O]H 2 O and subsequent radiofluorination of a broad range of substrates directly on the resin. The highest radiochemical yields were obtained with aliphatic sulfonates (69%) and bromides (42%); the total radiosynthesis time was 35-45 min. The multivariate analysis showed that the radiochemical yields and purities were controlled by the resin load, reaction temperature, and column packing effects. The resins could be reused several times with the same or different substrates. The fully automated on-column radiofluorination methodology was applied to the radiosynthesis of the important PET radiotracers [ recovery and processing, and column reusability can make solid phase radiofluorination an attractive radiochemistry platform for the emerging dose-on-demand instruments for bedside production of PET radiotracers.

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Section: Resultsmentioning

confidence: 99%

Automated Solid-Phase Radiofluorination Using Polymer-Supported Phosphazenes

Mathiessen

Zhuravlev

2013

Molecules

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“…Applying an anhydrous solution of crypt-222/KOH in CH3CN, however, enabled the quantitative elution of [ 18 F]fluoride under water-free conditions which was directly suitable for nucleophilic fluorination reactions [65,66]. A complete methodological alternative to avoid drying on a stationary phase is the conversion of [ 18 F]fluoride into gaseous [ 18 F]HF by acidification of the target water with H2SO4 in a glassy carbon/polyethylene vial which proceeds nearly quantitatively [67]. Here, the gaseous [ 18 F]HF is subsequently trapped on solid bound phosphazene bases, forming phosphazenium [ 18 F]hydrofluorides which activate the [ 18 F]fluoride for nucleophilic substitution reactions [67].…”

Section: [ 18 F]fluoride Drying Without Thermal Evaporationmentioning

confidence: 99%

“…A complete methodological alternative to avoid drying on a stationary phase is the conversion of [ 18 F]fluoride into gaseous [ 18 F]HF by acidification of the target water with H2SO4 in a glassy carbon/polyethylene vial which proceeds nearly quantitatively [67]. Here, the gaseous [ 18 F]HF is subsequently trapped on solid bound phosphazene bases, forming phosphazenium [ 18 F]hydrofluorides which activate the [ 18 F]fluoride for nucleophilic substitution reactions [67]. This method, however, appears technologically rather demanding for automation.…”

Section: [ 18 F]fluoride Drying Without Thermal Evaporationmentioning

confidence: 99%

18F-labelling innovations and their potential for clinical application

Coenen

Neumaier

2018

Clin Transl Imaging

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An impressive variety of new methodologies for the preparation of 18 F-labelled tracers and ligands has appeared over the last decade. Most strategies of the newly developed radiofluorination methods predominantly aim at products of high molar activity by 'late-stage' labelling of small (hetero)aromatic molecules and the use of transition metals. This is accompanied by the improvement of technical procedures, like preparation of reactive [ 18 F]fluoride and automated syntheses. The newly introduced procedures reflect a high innovative level and creativity in radio(pharmaceutical) chemistry at present, which are based on modern chemical methods and deep mechanistic insights. Taking also automation and quality control into consideration, major recently developed radiofluorination methods, most of those still under development, are compiled here in view of their potential for clinical PET imaging and thus the ability to advance molecular imaging.

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“…The [ 18 F]HF generator described by us earlier [19,20] was integrated within the automatic radiosynthesis platform (Fig.2 , top). After (Fig.2, bottom).…”

Section: Automated Radiosynthesis Of (R)-and (S)-[ 18 F]fmiso and Quamentioning

confidence: 99%